{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:44:43Z","timestamp":1790671483839,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neutrophils are essential during contact hypersensitivity (CHS), a common skin allergic disease. NF-E2\u2013related factor-2 (Nrf2) is a key regulator of redox balance and skin homeostasis playing a protective role in CHS. In this study, we investigated Nrf2 role in neutrophil recruitment during the sensitization phase of CHS. Comparing wild-type and Nrf2 knockout mice, we demonstrated that Nrf2 regulated dinitrochlorobenzene-induced xenoinflammation, notably neutrophil recruitment to sensitized skin. Nrf2 protective role was associated with high expression of antioxidant genes (ho-1, gclc, nqo1\u2026) and decreased chemokine production (CCL2, CCL4, CCL11). Interestingly, skin sensitization induced CD36 upregulation in skin-resident macrophages. In vitro results confirmed that the transcription of cd36 gene in macrophages was dependent on Nrf2 and led to an improved capacity to phagocyte-damaged neutrophils by efferocytosis. Nrf2 emerges as a critical target in the sensitization phase of CHS regulating neutrophil recruitment and accumulation in the skin through antioxidant-dependent and -independent mechanisms.<\/jats:p>","DOI":"10.4049\/jimmunol.1801065","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T21:09:07Z","timestamp":1552079347000},"page":"2189-2194","source":"Crossref","is-referenced-by-count":49,"title":["Cutting Edge: Nrf2 Regulates Neutrophil Recruitment and Accumulation in Skin during Contact Hypersensitivity"],"prefix":"10.1093","volume":"202","author":[{"given":"Doumet Georges","family":"Helou","sequence":"first","affiliation":[{"name":"Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry 92296 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry 92296 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Gaudin","sequence":"additional","affiliation":[{"name":"US31-UMS3679, La Plateforme d'Histologie sous Immunopathologie de Clamart, Institut Paris-Saclay d\u2019Innovation Th\u00e9rapeutique , Clamart 92140 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Groux","sequence":"additional","affiliation":[{"name":"Immunosearch , Grasse 06120 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina","family":"El Ali","sequence":"additional","affiliation":[{"name":"Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry 92296 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pallardy","sequence":"additional","affiliation":[{"name":"Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry 92296 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chollet-Martin","sequence":"additional","affiliation":[{"name":"Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry 92296 ,","place":["France"]},{"name":"Unit\u00e9 Fonctionnelle Auto-immunit\u00e9 et Hypersensibilit\u00e9s, H\u00f4pital Bichat, Assistance Publique H\u00f4pitaux de Paris , Paris 75877 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Kerdine-R\u00f6mer","sequence":"additional","affiliation":[{"name":"Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay , Ch\u00e2tenay-Malabry 92296 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"2025030417561737100_r1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat. 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