{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:58Z","timestamp":1787030878136,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gouty arthritis is an inflammatory disease that is triggered by abnormal uric acid metabolism, which is usually attributed to obesity, a risk factor of hyperuricemia and gout attack. A high level of leptin in plasma is a marker of individuals with obesity. Population studies show that leptin promotes obesity-related arthritis, such as osteoarthritis, but it is unknown whether leptin contributes to gouty arthritis, another form of obesity-related arthritis. Our present study showed that the levels of leptin and leptin receptor in patients with active gouty arthritis were elevated. Leptin facilitates the stimulation of human synoviocytes, mouse peritoneal macrophages, and HL-60 cells induced by monosodium urate, leading to higher levels of acute gout-related proinflammatory factors. Leptin obviously exacerbates the inflammation of monosodium urate\u2013induced acute gouty arthritis in wild-type mice, whereas that in leptin-deficient C57BL6\/Job\/ob mice is markedly alleviated. The proinflammatory effect of leptin in acute gouty arthritis is partly mediated by mTORC1 signaling pathway. Our study reveals that leptin may serve as a novel prevention and treatment target in acute gouty arthritis.<\/jats:p>","DOI":"10.4049\/jimmunol.1801097","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T14:24:12Z","timestamp":1553869452000},"page":"2728-2736","source":"Crossref","is-referenced-by-count":30,"title":["Leptin Promotes Monosodium Urate Crystal\u2013Induced Inflammation in Human and Murine Models of Gout"],"prefix":"10.1093","volume":"202","author":[{"given":"Yiyun","family":"Yu","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-0504","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Blood Engineering Laboratory, Shanghai Blood Center , Shanghai 200051 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Fu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xue","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minrui","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Xuan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Wan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lv","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejian","family":"Zou","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"Institute of Rheumatology, Immunology and Allergy, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"2025030417561770500_r1","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.4049\/jimmunol.1203275","article-title":"Cutting edge: leptin-induced ROR\u03b3t expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus","volume":"190","author":"Yu","year":"2013","journal-title":"J. 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