{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:28:10Z","timestamp":1787030890823,"version":"build-2736575974"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Genetic variants in C5orf30 have been associated with development of the autoimmune conditions primary biliary cirrhosis and rheumatoid arthritis. In rheumatoid arthritis, C5orf30 expression is cell-specific, with highest expression found in macrophages and synovial fibroblasts. C5orf30 is highly expressed in inflamed joints and is a negative regulator of tissue damage in a mouse model of inflammatory arthritis. Transcriptomic analysis from ultrasound-guided synovial biopsy of inflamed joints in a well characterized clinical cohort of newly diagnosed, disease-modifying antirheumatic drugs\u2013naive rheumatoid arthritis patients was used to determine the clinical association of C5orf30 expression with disease activity. A combined molecular and computational biology approach was used to elucidate C5orf30 function in macrophages both in vitro and in vivo. Synovial expression of C5orf30 is inversely correlated with both clinical measures of rheumatoid arthritis disease activity and with synovial TNF mRNA expression. C5orf30 plays a role in regulating macrophage phenotype and is differentially turned over in inflammatory and anti-inflammatory macrophages. Inhibition of C5orf30 reduces wound healing\/repair\u2013associated functions of macrophages, reduces signaling required for resolution of inflammation, and decreases secretion of anti-inflammatory mediators. In an animal model of wound healing (zebrafish), C5orf30 inhibition increases the recruitment of macrophages to the wound site. Finally, we demonstrate that C5orf30 skews macrophage immunometabolism, demonstrating a mechanism for C5orf30-mediated immune regulation.<\/jats:p>","DOI":"10.4049\/jimmunol.1801155","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T18:09:17Z","timestamp":1547834957000},"page":"1069-1078","source":"Crossref","is-referenced-by-count":20,"title":["The Autoimmune Susceptibility Gene\n                    <i>C5orf30<\/i>\n                    Regulates Macrophage-Mediated Resolution of Inflammation"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-934X","authenticated-orcid":false,"given":"Emma R","family":"Dorris","sequence":"first","affiliation":[{"name":"University College Dublin Centre for Arthritis Research, Conway Institute, University College Dublin , Dublin D04 W6F6 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-9989","authenticated-orcid":false,"given":"Simon J","family":"Tazzyman","sequence":"additional","affiliation":[{"name":"University of Sheffield , Sheffield S10 2RX ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-0166","authenticated-orcid":false,"given":"John","family":"Moylett","sequence":"additional","affiliation":[{"name":"University College Dublin Centre for Arthritis Research, Conway Institute, University College Dublin , Dublin D04 W6F6 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandhini","family":"Ramamoorthi","sequence":"additional","affiliation":[{"name":"Biomarker Discovery OMNI, Genentech Research and Early Development , San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-563X","authenticated-orcid":false,"given":"Jason","family":"Hackney","sequence":"additional","affiliation":[{"name":"Biomarker Discovery OMNI, Genentech Research and Early Development , San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Townsend","sequence":"additional","affiliation":[{"name":"Biomarker Discovery OMNI, Genentech Research and Early Development , San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-8903","authenticated-orcid":false,"given":"Munitta","family":"Muthana","sequence":"additional","affiliation":[{"name":"University of Sheffield , Sheffield S10 2RX ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-5345","authenticated-orcid":false,"given":"Myles J","family":"Lewis","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry and Barts Health National Health Service Trust, Queen Mary University of London , London EC1M 6BQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-5051","authenticated-orcid":false,"given":"Costantino","family":"Pitzalis","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry and Barts Health National Health Service Trust, Queen Mary University of London , London EC1M 6BQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-3926","authenticated-orcid":false,"given":"Anthony G","family":"Wilson","sequence":"additional","affiliation":[{"name":"University College Dublin Centre for Arthritis Research, Conway Institute, University College Dublin , Dublin D04 W6F6 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"2025030417560795700_r1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/ng.582","article-title":"Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci","volume":"42","author":"Stahl","year":"2010","journal-title":"Nat. Genet."},{"key":"2025030417560795700_r2","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1038\/ncomms9019","article-title":"International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways","volume":"6","author":"Cordell","year":"2015","journal-title":"Nat. Commun."},{"key":"2025030417560795700_r3","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1136\/annrheumdis-2011-201225","article-title":"Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients","volume":"71","author":"Viatte","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"2025030417560795700_r4","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/art.38064","article-title":"Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis","volume":"65","author":"Teare","year":"2013","journal-title":"Arthritis Rheum."},{"key":"2025030417560795700_r5","doi-asserted-by":"crossref","first-page":"11618","DOI":"10.1073\/pnas.1501947112","article-title":"C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis","volume":"112","author":"Muthana","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417560795700_r6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fimmu.2014.00514","article-title":"From monocytes to M1\/M2 macrophages: phenotypical vs. functional differentiation","volume":"5","author":"Italiani","year":"2014","journal-title":"Front. Immunol."},{"key":"2025030417560795700_r7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025030417560795700_r8","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J. Immunol."},{"key":"2025030417560795700_r9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"key":"2025030417560795700_r10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"2025030417560795700_r11","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1101\/gad.173443.111","article-title":"An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium","volume":"25","author":"Wright","year":"2011","journal-title":"Genes Dev."},{"key":"2025030417560795700_r12","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1016\/j.ajpath.2014.06.025","article-title":"Novel fusion transcripts associate with progressive prostate cancer","volume":"184","author":"Yu","year":"2014","journal-title":"Am. J. Pathol."},{"key":"2025030417560795700_r13","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.4049\/jimmunol.1400486","article-title":"Modulation of TNF-induced macrophage polarization by synovial fibroblasts","volume":"193","author":"Donlin","year":"2014","journal-title":"J. Immunol."},{"key":"2025030417560795700_r14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417560795700_r15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/rheumatology\/kes304","article-title":"Targeting monocytes\/macrophages in the treatment of rheumatoid arthritis","volume":"52","author":"Davignon","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"2025030417560795700_r16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fimmu.2015.00571","article-title":"The interplay between monocytes\/macrophages and CD4(+) T cell subsets in rheumatoid arthritis","volume":"6","author":"Roberts","year":"2015","journal-title":"Front. Immunol."},{"key":"2025030417560795700_r17","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3389\/fimmu.2017.01958","article-title":"M1 and M2 monocytes in rheumatoid arthritis: a contribution of imbalance of M1\/M2 monocytes to osteoclastogenesis","volume":"8","author":"Fukui","year":"2018","journal-title":"Front. Immunol."},{"key":"2025030417560795700_r18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.intimp.2017.07.019","article-title":"Is macrophage polarization important in rheumatoid arthritis?","volume":"50","author":"Wang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"2025030417560795700_r19","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Immunol."},{"key":"2025030417560795700_r20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fimmu.2017.00415","article-title":"Editorial: regulation of inflammation, its resolution and therapeutic targeting","volume":"8","author":"Uguccioni","year":"2017","journal-title":"Front. Immunol."},{"key":"2025030417560795700_r21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fimmu.2016.00224","article-title":"Atypical chemokine receptors and their roles in the resolution of the inflammatory response","volume":"7","author":"Bonecchi","year":"2016","journal-title":"Front. Immunol."},{"key":"2025030417560795700_r22","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.drudis.2014.06.023","article-title":"Resolution of inflammation: targeting GPCRs that interact with lipids and peptides","volume":"19","author":"Cash","year":"2014","journal-title":"Drug Discov. Today"},{"key":"2025030417560795700_r23","first-page":"1548","article-title":"Targeting pro-resolution pathways to combat chronic inflammation in COPD","volume":"6","author":"Bozinovski","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"2025030417560795700_r24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/annrheumdis-2013-204603","article-title":"Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients","volume":"74","author":"Kelly","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"2025030417560795700_r25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.gene.6364339","article-title":"Haplotype-specific gene expression profiles in a telomeric major histocompatibility complex gene cluster and susceptibility to autoimmune diseases","volume":"7","author":"Mewar","year":"2006","journal-title":"Genes Immun."},{"key":"2025030417560795700_r26","doi-asserted-by":"crossref","first-page":"C1358","DOI":"10.1152\/ajpcell.00553.2003","article-title":"Extracellular pressure stimulates macrophage phagocytosis by inhibiting a pathway involving FAK and ERK","volume":"286","author":"Shiratsuchi","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2025030417560795700_r27","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1038\/s41598-017-08121-8","article-title":"Classification of M1\/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis","volume":"7","author":"Bertani","year":"2017","journal-title":"Sci. Rep."},{"key":"2025030417560795700_r28","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.4049\/jimmunol.1402190","article-title":"Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes","volume":"194","author":"Saha","year":"2015","journal-title":"J. Immunol."},{"key":"2025030417560795700_r29","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1080\/15384047.2016.1139230","article-title":"Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines","volume":"17","author":"Dorris","year":"2016","journal-title":"Cancer Biol. Ther."},{"key":"2025030417560795700_r30","doi-asserted-by":"crossref","first-page":"72021","DOI":"10.18632\/oncotarget.18894","article-title":"MARCKS promotes invasion and is associated with biochemical recurrence in prostate cancer","volume":"8","author":"Dorris","year":"2017","journal-title":"Oncotarget"},{"key":"2025030417560795700_r31","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/pros.23389","article-title":"Investigating the role of the IGF axis as a predictor of biochemical recurrence in prostate cancer patients post-surgery","volume":"77","author":"Breen","year":"2017","journal-title":"Prostate"},{"key":"2025030417560795700_r32","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1128\/IAI.71.4.2087-2094.2003","article-title":"Pneumolysin-dependent and -independent gene expression identified by cDNA microarray analysis of THP-1 human mononuclear cells stimulated by Streptococcus pneumoniae","volume":"71","author":"Rogers","year":"2003","journal-title":"Infect. Immun."},{"key":"2025030417560795700_r33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.atherosclerosis.2011.09.003","article-title":"The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature","volume":"221","author":"Qin","year":"2012","journal-title":"Atherosclerosis"},{"key":"2025030417560795700_r34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1478-811X-11-52","article-title":"When ubiquitination meets phosphorylation: a systems biology perspective of EGFR\/MAPK signalling","volume":"11","author":"Nguyen","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"2025030417560795700_r35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2519","article-title":"Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation","volume":"10","author":"Swaney","year":"2013","journal-title":"Nat. Methods"},{"key":"2025030417560795700_r36","doi-asserted-by":"crossref","first-page":"580","DOI":"10.4049\/jimmunol.176.1.580","article-title":"Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway","volume":"176","author":"Grishin","year":"2006","journal-title":"J. Immunol."},{"key":"2025030417560795700_r37","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1073\/pnas.251194298","article-title":"SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase","volume":"98","author":"Bennett","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417560795700_r38","first-page":"240ra73","article-title":"Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs","volume-title":"Sci. Transl. Med.","author":"Aflaki","year":"2014"},{"key":"2025030417560795700_r39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41467-018-02885-x","article-title":"Creation of a long-acting nanoformulated dolutegravir","volume":"9","author":"Sillman","year":"2018","journal-title":"Nat. Commun."},{"key":"2025030417560795700_r40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.canlet.2014.07.035","article-title":"Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett\u2019s oesophagus","volume":"354","author":"Phelan","year":"2014","journal-title":"Cancer Lett."},{"key":"2025030417560795700_r41","doi-asserted-by":"crossref","first-page":"e96786","DOI":"10.1371\/journal.pone.0096786","article-title":"Glucose controls morphodynamics of LPS-stimulated macrophages","volume":"9","author":"Venter","year":"2014","journal-title":"PLoS One"},{"key":"2025030417560795700_r42","doi-asserted-by":"crossref","first-page":"e100738","DOI":"10.1371\/journal.pone.0100738","article-title":"Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma","volume":"9","author":"Lynam-Lennon","year":"2014","journal-title":"PLoS One"},{"key":"2025030417560795700_r43","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1038\/s41598-017-03921-4","article-title":"Hif-1\u03b1 knockdown reduces glycolytic metabolism and induces cell death of human synovial fibroblasts under normoxic conditions","volume":"7","author":"Del Rey","year":"2017","journal-title":"Sci. Rep."},{"key":"2025030417560795700_r44","doi-asserted-by":"crossref","first-page":"E546","DOI":"10.1152\/ajpendo.00180.2015","article-title":"Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis","volume":"309","author":"Gardner","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2025030417560795700_r45","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1160\/TH10-08-0525","article-title":"Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish","volume":"105","author":"Gray","year":"2011","journal-title":"Thromb. Haemost."},{"key":"2025030417560795700_r46","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/prot.10532","article-title":"Predicting intrinsic disorder from amino acid sequence","volume":"53","author":"Obradovic","year":"2003","journal-title":"Proteins"},{"key":"2025030417560795700_r47","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nbt849","article-title":"A proteomics approach to understanding protein ubiquitination","volume":"21","author":"Peng","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"2025030417560795700_r48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2013.02.005","article-title":"Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro","volume":"32","author":"Chhor","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"2025030417560795700_r49","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni.1699","article-title":"The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules","volume":"10","author":"Hao","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030417560795700_r50","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control. [Published erratum appears in 2013 Nature 495: 126\u2013127.]","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"2025030417560795700_r51","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1471-2164-6-137","article-title":"A TNF-induced gene expression program under oscillatory NF-kappaB control","volume":"6","author":"Tian","year":"2005","journal-title":"BMC Genomics"},{"key":"2025030417560795700_r52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrm3496","article-title":"Protein homeostasis: live long, won\u2019t prosper","volume":"14","author":"Toyama","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025030417560795700_r53","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1128\/MCB.01011-13","article-title":"p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi\u2019s sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3","volume":"34","author":"Baresova","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"2025030417560795700_r54","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1038\/sj.onc.1204423","article-title":"Post-transcriptional inactivation of p53 in immortalized murine embryo fibroblast cells","volume":"20","author":"Kim","year":"2001","journal-title":"Oncogene"},{"key":"2025030417560795700_r55","doi-asserted-by":"crossref","first-page":"rs3","DOI":"10.1126\/scisignal.2001570","article-title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation","volume":"4","author":"Rigbolt","year":"2011","journal-title":"Sci. Signal."},{"key":"2025030417560795700_r56","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1227568","article-title":"JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation","volume":"339","author":"Han","year":"2013","journal-title":"Science"},{"key":"2025030417560795700_r57","doi-asserted-by":"crossref","first-page":"e94188","DOI":"10.1371\/journal.pone.0094188","article-title":"The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages","volume":"9","author":"Fernando","year":"2014","journal-title":"PLoS One"},{"key":"2025030417560795700_r58","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ni.2865","article-title":"Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin","volume":"15","author":"Mauer","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030417560795700_r59","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4049\/jimmunol.1402088","article-title":"MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway","volume":"194","author":"Ying","year":"2015","journal-title":"J. Immunol."},{"key":"2025030417560795700_r60","first-page":"eaal3321","article-title":"A subcellular map of the human proteome","volume-title":"Science","author":"Thul","year":"2017"},{"key":"2025030417560795700_r61","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/science.aal3535","article-title":"Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages","volume":"356","author":"Ip","year":"2017","journal-title":"Science"},{"key":"2025030417560795700_r62","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood-2006-05-024075","article-title":"A transgenic zebrafish model of neutrophilic inflammation","volume":"108","author":"Renshaw","year":"2006","journal-title":"Blood"},{"key":"2025030417560795700_r63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0090-1229(86)90049-8","article-title":"In situ characterization of the cell-surface antigens of the mononuclear cell infiltrate and bile duct epithelium in primary biliary cirrhosis","volume":"41","author":"Colucci","year":"1986","journal-title":"Clin. Immunol. Immunopathol."},{"key":"2025030417560795700_r64","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4292\/wjgpt.v6.i3.32","article-title":"Primary biliary cirrhosis: from bench to bedside","volume":"6","author":"Kouroumalis","year":"2015","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"2025030417560795700_r65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2559.1994.tb00599.x","article-title":"Quantitative analysis of macrophages and perisinusoidal cells in primary biliary cirrhosis","volume":"25","author":"Mathew","year":"1994","journal-title":"Histopathology"},{"key":"2025030417560795700_r66","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1186\/ar2073","article-title":"Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal\/fibrotic characteristics","volume":"8","author":"Steenvoorden","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"2025030417560795700_r67","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbadis.2012.12.001","article-title":"Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair","volume":"1832","author":"Lech","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"2025030417560795700_r68","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"2025030417560795700_r69","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"2025030417560795700_r70","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nm.4373","article-title":"Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells","volume":"23","author":"Rauber","year":"2017","journal-title":"Nat. Med."},{"key":"2025030417560795700_r71","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.tips.2015.07.007","article-title":"Resolution pharmacology: opportunities for therapeutic innovation in inflammation","volume":"36","author":"Perretti","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"2025030417560795700_r72","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.molcel.2007.11.019","article-title":"The age of crosstalk: phosphorylation, ubiquitination, and beyond","volume":"28","author":"Hunter","year":"2007","journal-title":"Mol. Cell"},{"key":"2025030417560795700_r73","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.RES.0000170084.88780.ea","article-title":"Phosphorylation of serine 188 protects RhoA from ubiquitin\/proteasome-mediated degradation in vascular smooth muscle cells","volume":"96","author":"Rolli-Derkinderen","year":"2005","journal-title":"Circ. Res."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/202\/4\/1069\/61434611\/ji1801155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/202\/4\/1069\/61434611\/ji1801155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T14:28:27Z","timestamp":1741098507000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/202\/4\/1069\/7953830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1801155","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2019,2]]}}}