{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:21:57Z","timestamp":1777576917235,"version":"3.51.4"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adenoviral vectors can induce T and B cell immune responses to Ags encoded in the recombinant vector. The MHC class II invariant chain (Ii) has been used as an adjuvant to enhance T cell responses to tethered Ag encoded in adenoviral vectors. In this study, we modified the Ii adjuvant by insertion of a furin recognition site (Ii-fur) to obtain a secreted version of the Ii. To test the capacity of this adjuvant to enhance immune responses, we recombined vectors to encode Plasmodium falciparum virulence factors: two cysteine-rich interdomain regions (CIDR) \u03b11 (IT4var19 and PFCLINvar30 var genes), expressed as a dimeric Ag. These domains are members of a highly polymorphic protein family involved in the vascular sequestration and immune evasion of parasites in malaria. The Ii-fur molecule directed secretion of both Ags in African green monkey cells and functioned as an adjuvant for MHC class I and II presentation in T cell hybridomas. In mice, the Ii-fur adjuvant induced a similar T cell response, as previously demonstrated with Ii, accelerated and enhanced the specific Ab response against both CIDR Ags, with an increased binding capacity to the cognate endothelial protein C receptor, and enhanced the breadth of the response toward different CIDRs. We also demonstrate that the endosomal sorting signal, secretion, and the C-terminal part of Ii were needed for the full adjuvant effect for Ab responses. We conclude that engineered secretion of Ii adjuvant\u2013tethered Ags establishes a single adjuvant and delivery vehicle platform for potent T and B cell\u2013dependent immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1801210","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T17:35:16Z","timestamp":1551720916000},"page":"2320-2331","source":"Crossref","is-referenced-by-count":11,"title":["Modified MHC Class II\u2013Associated Invariant Chain Induces Increased Antibody Responses against <i>Plasmodium falciparum<\/i> Antigens after Adenoviral Vaccination"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-8377","authenticated-orcid":false,"given":"Cyrielle","family":"Fougeroux","sequence":"first","affiliation":[{"name":"Center for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Turner","sequence":"additional","affiliation":[{"name":"Center for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders Miki","family":"Bojesen","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, University of Copenhagen , 1870 Frederiksberg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lavstsen","sequence":"additional","affiliation":[{"name":"Center for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Johannes","family":"Holst","sequence":"additional","affiliation":[{"name":"Center for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"2025030417561740100_r1","doi-asserted-by":"crossref","first-page":"16030","DOI":"10.1038\/mtm.2016.30","article-title":"Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens","volume":"3","author":"Afkhami","year":"2016","journal-title":"Mol. 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