{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:35:13Z","timestamp":1793284513334,"version":"4.5.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD4 Th cells are organizers of the immune response, directing other immune cells to initiate and maintain effective humoral and cellular immunity. CD4 T cells differentiate into distinct Th effector or regulatory subsets in response to signals delivered to them during the course of infection. Ikaros is a transcription factor that is expressed in blood cells from the level of the hematopoietic stem cell. It is required for normal thymic T cell development and serves as a tumor suppressor, as lack of Ikaros in developing lymphoid cells results in leukemia. To study the role of Ikaros in CD4 T cell differentiation and function, an Ikaros conditional knockout mouse was developed such that Ikaros expression was deleted specifically in mature T cells, thus avoiding defects observed in germline Ikaros mutant mice. Using this model system, we have shown that in the absence of Ikaros, CD4 T cells are able to attain Th1, Th2, and Th17, but not inducible regulatory T, cell fates. However, they show enhanced expression of a cohort of proinflammatory cytokines, resulting in differentiation of Th17 cells with a phenotype that has been associated with autoimmunity and pathological inflammation. In addition, we define Ikaros as a repressor of the gene program associated with the response to type I IFNs, another key pathway whose deregulation is linked to autoimmunity. Taken together, these data definitively define Ikaros as a critical regulator at the center of the inflammatory response in T cells and highlight a potential role in suppressing autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1801270","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T22:35:14Z","timestamp":1547246114000},"page":"1112-1123","source":"Crossref","is-referenced-by-count":37,"title":["Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-1624","authenticated-orcid":false,"given":"Carolina","family":"Lyon de Ana","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Immunology Training Program, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenia","family":"Arakcheeva","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Immunology Training Program, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Agnihotri","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Immunology Training Program, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Derosia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Immunology Training Program, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7804-9603","authenticated-orcid":false,"given":"Susan","family":"Winandy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Immunology Training Program, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"2025030417560538500_r1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.immunol.15.1.155","article-title":"The role of the Ikaros gene in lymphocyte development and homeostasis","volume":"15","author":"Georgopoulos","year":"1997","journal-title":"Annu. 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[Published erratum appears in 2011 PLoS Genet. 7.]","volume":"7","author":"Gorlova","year":"2011","journal-title":"PLoS Genet."},{"key":"2025030417560538500_r10","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1182\/blood-2002-05-1336","article-title":"Ikaros regulates neutrophil differentiation","volume":"101","author":"Dumortier","year":"2003","journal-title":"Blood"},{"key":"2025030417560538500_r11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1073\/pnas.022412699","article-title":"Multiple hematopoietic defects and delayed globin switching in Ikaros null mice","volume":"99","author":"Lopez","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417560538500_r12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/smim.1998.0113","article-title":"Ikaros in hemopoietic lineage determination and homeostasis","volume":"10","author":"Nichogiannopoulou","year":"1998","journal-title":"Semin. 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