{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:59:57Z","timestamp":1785365997156,"version":"3.55.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aging of established antiviral T cell memory can foster a series of progressive adaptations that paradoxically improve rather than compromise protective CD8+ T cell immunity. We now provide evidence that this gradual evolution, the pace of which is contingent on the precise context of the primary response, also impinges on the molecular mechanisms that regulate CD8+ memory T cell (TM) homeostasis. Over time, CD8+ TM generated in the wake of an acute infection with the natural murine pathogen lymphocytic choriomeningitis virus become more resistant to apoptosis and acquire enhanced cytokine responsiveness without adjusting their homeostatic proliferation rates; concurrent metabolic adaptations promote increased CD8+ TM quiescence and fitness but also impart the reacquisition of a partial effector-like metabolic profile; and a gradual redistribution of aging CD8+ TM from blood and nonlymphoid tissues to lymphatic organs results in CD8+ TM accumulations in bone marrow, splenic white pulp, and, particularly, lymph nodes. Altogether, these data demonstrate how temporal alterations of fundamental homeostatic determinants converge to render aged CD8+ TM poised for greater recall responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1801277","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T17:56:34Z","timestamp":1544810194000},"page":"460-475","source":"Crossref","is-referenced-by-count":24,"title":["Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing"],"prefix":"10.1093","volume":"202","author":[{"given":"Bennett","family":"Davenport","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Colorado Denver , Aurora, CO 80045"},{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver , Aurora, CO 80045"},{"name":"Integrated Department of Immunology, University of Colorado Denver and National Jewish Health , Denver, CO 80045"},{"name":"Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029"},{"name":"Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-1767","authenticated-orcid":false,"given":"Jens","family":"Eberlein","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado Denver , Aurora, CO 80045"},{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado Denver , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-4405","authenticated-orcid":false,"given":"Verena","family":"van der Heide","sequence":"additional","affiliation":[{"name":"Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029"},{"name":"Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY 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