{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:58:51Z","timestamp":1788785931469,"version":"build-2803163510"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Deregulated immune response to a dysbiotic resident microflora within the oral cavity leads to chronic periodontal disease, local tissue destruction, and various systemic complications. To preserve tissue homeostasis, inflammatory signaling pathways involved in the progression of periodontitis must be tightly regulated. A20 (TNFAIP3), a ubiquitin-editing enzyme, has emerged as one of the key regulators of inflammation. Yet, the function of A20 in the oral mucosa and the biological pathways in which A20 mitigates periodontal inflammation remain elusive. Using a combination of in vivo and ex vivo disease models, we report in this study that A20 regulates inflammatory responses to a keystone oral bacterium, Porphyromonas gingivalis, and restrains periodontal inflammation through its effect on NF-\u03baB signaling and cytokine production. Depletion of A20 using gene editing in human macrophage-like cells (THP-1) significantly increased cytokine secretion, whereas A20 overexpression using lentivirus infection dampened the cytokine production following bacterial challenge through modulating NF-\u03baB activity. Similar to human cells, bone marrow\u2013derived macrophages from A20-deficient mice infected with P. gingivalis displayed increased NF-\u03baB activity and cytokine production compared with the cells isolated from A20-competent mice. Subsequent experiments using a murine ligature-induced periodontitis model showed that even a partial loss of A20 promotes an increased inflammatory phenotype and more severe bone loss, further verifying the critical function of A20 in the oral mucosa. Collectively, to our knowledge, these findings reveal the first systematic evidence of a physiological role for A20 in the maintenance of oral tissue homeostasis as a negative regulator of inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1801286","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T20:49:43Z","timestamp":1550090983000},"page":"2044-2056","source":"Crossref","is-referenced-by-count":25,"title":["A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-\u03baB Activity"],"prefix":"10.1093","volume":"202","author":[{"given":"Yajie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Periodontics, School of Dentistry, Virginia Commonwealth University , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C","family":"Mooney","sequence":"additional","affiliation":[{"name":"Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dentistry, Virginia Commonwealth University , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia-Juan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dentistry, Virginia Commonwealth University , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University , Richmond, VA 23284"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University , Richmond, VA 23298"},{"name":"Departments of Obstetrics and Gynecology, School of Medicine, Virginia Commonwealth University , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-1258","authenticated-orcid":false,"given":"Averil","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-637X","authenticated-orcid":false,"given":"Sinem E","family":"Sahingur","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dentistry, Virginia Commonwealth University , Richmond, VA 23298"},{"name":"Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"2025030417561395100_r1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/prd.12222","article-title":"The periodontal war: microbes and immunity","volume":"75","author":"Ebersole","year":"2017","journal-title":"Periodontol. 2000"},{"key":"2025030417561395100_r2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/prd.12181","article-title":"Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later","volume":"75","author":"Hajishengallis","year":"2017","journal-title":"Periodontol. 2000"},{"key":"2025030417561395100_r3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/0022034515609062","article-title":"Microbial nucleic acid sensing in oral and systemic diseases","volume":"95","author":"Crump","year":"2016","journal-title":"J. Dent. Res."},{"key":"2025030417561395100_r4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-0757.2011.00413.x","article-title":"Global periodontal disease epidemiology","volume":"58","author":"Dye","year":"2012","journal-title":"Periodontol. 2000"},{"key":"2025030417561395100_r5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2011.06460.x","article-title":"Diabetes and oral disease: implications for health professionals","volume":"1255","author":"Albert","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025030417561395100_r6","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1111\/jcpe.12060","article-title":"Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases","volume":"40","author":"Schenkein","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"2025030417561395100_r7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/0022034514528334","article-title":"Periodontal disease, atherosclerosis, adverse pregnancy outcomes, and head-and-neck cancer","volume":"26","author":"Han","year":"2014","journal-title":"Adv. Dent. Res."},{"key":"2025030417561395100_r8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s11926-014-0408-9","article-title":"The link between periodontal disease and rheumatoid arthritis: an updated review","volume":"16","author":"Koziel","year":"2014","journal-title":"Curr. Rheumatol. Rep."},{"key":"2025030417561395100_r9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ncb0805-758","article-title":"Ubiquitin signalling in the NF-kappaB pathway","volume":"7","author":"Chen","year":"2005","journal-title":"Nat. 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Ther."},{"key":"2025030417561395100_r32","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417561395100_r33","doi-asserted-by":"crossref","first-page":"ra28","DOI":"10.1126\/scisignal.2000202","article-title":"Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105","volume":"2","author":"Wall","year":"2009","journal-title":"Sci. Signal."},{"key":"2025030417561395100_r34","doi-asserted-by":"crossref","first-page":"22886","DOI":"10.1074\/jbc.M110.199950","article-title":"Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity","volume":"286","author":"Colleran","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2025030417561395100_r35","doi-asserted-by":"crossref","first-page":"S484","DOI":"10.2337\/diabetes.51.2007.S484","article-title":"Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells","volume":"51","author":"Bernal-Mizrachi","year":"2002","journal-title":"Diabetes"},{"key":"2025030417561395100_r36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jim.2015.03.018","article-title":"Simultaneous assessment of NF-\u03baB\/p65 phosphorylation and nuclear localization using imaging flow cytometry","volume":"423","author":"Maguire","year":"2015","journal-title":"J. Immunol. Methods"},{"key":"2025030417561395100_r37","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.4049\/jimmunol.1102674","article-title":"Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis","volume":"188","author":"Derive","year":"2012","journal-title":"J. Immunol."},{"key":"2025030417561395100_r38","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4049\/jimmunol.1101027","article-title":"Cutting edge: regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-\u03baB nuclear accumulation in CD4 T cells","volume":"188","author":"Huang","year":"2012","journal-title":"J. Immunol."},{"key":"2025030417561395100_r39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1474-9726.2011.00759.x","article-title":"Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly","volume":"11","author":"Qian","year":"2012","journal-title":"Aging Cell"},{"key":"2025030417561395100_r40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0757.2012.00450.x","article-title":"Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts","volume":"62","author":"Bartold","year":"2013","journal-title":"Periodontol. 2000"},{"key":"2025030417561395100_r41","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-0757.2006.00166.x","article-title":"Novel host response therapeutic approaches to treat periodontal diseases","volume":"43","author":"Kirkwood","year":"2007","journal-title":"Periodontol. 2000"},{"key":"2025030417561395100_r42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/prd.12169","article-title":"Host modulation: controlling the inflammation to control the infection","volume":"75","author":"Bartold","year":"2017","journal-title":"Periodontol. 2000"},{"key":"2025030417561395100_r43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni.2823","article-title":"The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation","volume":"15","author":"Tiruppathi","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030417561395100_r44","doi-asserted-by":"crossref","first-page":"e87425","DOI":"10.1371\/journal.pone.0087425","article-title":"Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function","volume":"9","author":"Nagamachi","year":"2014","journal-title":"PLoS One"},{"key":"2025030417561395100_r45","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1038\/ncomms6103","article-title":"A20 controls intestinal homeostasis through cell-specific activities","volume":"5","author":"Vereecke","year":"2014","journal-title":"Nature Commun."},{"key":"2025030417561395100_r46","first-page":"pii: ftw015","article-title":"Mycobacterium fortuitum induces A20 expression that impairs macrophage inflammatory responses","volume-title":"Pathog. Dis.","author":"Lee","year":"2016"},{"key":"2025030417561395100_r47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbrc.2012.08.051","article-title":"Probiotics promote endocytic allergen degradation in gut epithelial cells","volume":"426","author":"Song","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030417561395100_r48","doi-asserted-by":"crossref","first-page":"e59259","DOI":"10.1371\/journal.pone.0059259","article-title":"Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells through modulation of ubiquitin-editing enzyme A20 expression","volume":"8","author":"Tomosada","year":"2013","journal-title":"PLoS One"},{"key":"2025030417561395100_r49","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12931-018-0825-9","article-title":"Comparison of pro- and anti-inflammatory responses in paired human primary airway epithelial cells and alveolar macrophages","volume":"19","author":"Mubarak","year":"2018","journal-title":"Respir. Res."},{"key":"2025030417561395100_r50","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2249.2009.04048.x","article-title":"A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation","volume":"159","author":"Oshima","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"2025030417561395100_r51","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4292\/wjgpt.v7.i4.540","article-title":"A20 inhibits lipopolysaccharide-induced inflammation in enterocytes","volume":"7","author":"Zheng","year":"2016","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"2025030417561395100_r52","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/eji.201444795","article-title":"A20 expression in dendritic cells protects mice from LPS-induced mortality","volume":"45","author":"Xuan","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"2025030417561395100_r53","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nm1721","article-title":"A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression","volume":"14","author":"Song","year":"2008","journal-title":"Nat. Med."},{"key":"2025030417561395100_r54","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1182\/blood-2010-09-306019","article-title":"B cells lacking the tumor suppressor TNFAIP3\/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice","volume":"117","author":"Chu","year":"2011","journal-title":"Blood"},{"key":"2025030417561395100_r55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.immuni.2010.07.017","article-title":"The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity","volume":"33","author":"Tavares","year":"2010","journal-title":"Immunity"},{"key":"2025030417561395100_r56","first-page":"411","article-title":"Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis","volume-title":"J. Cyst. 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Genet."},{"key":"2025030417561395100_r60","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1084\/jem.20092474","article-title":"Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis","volume":"207","author":"Vereecke","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025030417561395100_r61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41598-017-18693-0","article-title":"Loss of A20 in BM-MSCs regulates the Th17\/Treg balance in rheumatoid arthritis","volume":"8","author":"Feng","year":"2018","journal-title":"Sci. Rep."},{"key":"2025030417561395100_r62","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jcpe.12238","article-title":"The presence, function and regulation of IL-17 and Th17 cells in periodontitis","volume":"41","author":"Cheng","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"2025030417561395100_r63","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12967-015-0566-1","article-title":"Characteristics of A20 gene polymorphisms and clinical significance in patients with rheumatoid arthritis","volume":"13","author":"Zhu","year":"2015","journal-title":"J. Transl. Med."},{"key":"2025030417561395100_r64","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/ng.200","article-title":"Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus","volume":"40","author":"Graham","year":"2008","journal-title":"Nat. Genet."},{"key":"2025030417561395100_r65","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1136\/ard.2009.127928","article-title":"Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population","volume":"69","author":"Dieud\u00e9","year":"2010","journal-title":"Ann. Rheum. 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