{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:15:55Z","timestamp":1792451755469,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Regulatory T cell (Treg) therapy is a potential curative approach for a variety of immune-mediated conditions, including autoimmunity and transplantation, in which there is pathological tissue damage. In mice, IL-33R (ST2)\u2013expressing Tregs mediate tissue repair by producing the growth factor amphiregulin, but whether similar tissue-reparative Tregs exist in humans remains unclear. We show that human Tregs in blood and multiple tissue types produced amphiregulin, but this was neither a unique feature of Tregs nor selectively upregulated in tissues. Human Tregs in blood, tonsil, synovial fluid, colon, and lung tissues did not express ST2, so ST2+ Tregs were engineered via lentiviral-mediated overexpression, and their therapeutic potential for cell therapy was examined. Engineered ST2+ Tregs exhibited TCR-independent, IL-33\u2013stimulated amphiregulin expression and a heightened ability to induce M2-like macrophages. The finding that amphiregulin-producing Tregs have a noneffector phenotype and are progressively lost upon TCR-induced proliferation and differentiation suggests that the tissue repair capacity of human Tregs may be an innate function that operates independently from their classical suppressive function.<\/jats:p>","DOI":"10.4049\/jimmunol.1801330","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T21:05:45Z","timestamp":1552079145000},"page":"2195-2209","source":"Crossref","is-referenced-by-count":46,"title":["Innate Control of Tissue-Reparative Human Regulatory T Cells"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7794-1325","authenticated-orcid":false,"given":"Avery J","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Surgery, University of British Columbia , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]},{"name":"BC Children\u2019s Hospital Research Institute , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-2757","authenticated-orcid":false,"given":"Katherine N","family":"MacDonald","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital Research Institute , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]},{"name":"School of Biomedical Engineering, University of British Columbia , Vancouver, British Columbia V6T 1Z4 ,","place":["Canada"]},{"name":"Michael Smith Laboratories, University of British Columbia , Vancouver, British Columbia V6T 1Z4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7968-0277","authenticated-orcid":false,"given":"Anne M","family":"Pesenacker","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of British Columbia , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]},{"name":"BC Children\u2019s Hospital Research Institute , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-556X","authenticated-orcid":false,"given":"Stephen C","family":"Juvet","sequence":"additional","affiliation":[{"name":"Division of Respirology, Department of Medicine, University of Toronto , Toronto, Ontario M5G 2C4 ,","place":["Canada"]},{"name":"Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario M5G 2C4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-4002","authenticated-orcid":false,"given":"Kimberly A","family":"Morishita","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital Research Institute , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]},{"name":"Division of Rheumatology, Department of Pediatrics, University of British Columbia , Vancouver, British Columbia V5Z 4H4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bressler","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of British Columbia , Vancouver, British Columbia V6Z 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"iGenoMed Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7144-726X","authenticated-orcid":false,"given":"James G","family":"Pan","sequence":"additional","affiliation":[{"name":"Toronto Recombinant Antibody Centre, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , Toronto, Ontario M5S 3E1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-5918","authenticated-orcid":false,"given":"Sachdev S","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Toronto Recombinant Antibody Centre, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , Toronto, Ontario M5S 3E1 ,","place":["Canada"]},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S 1A8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-8326","authenticated-orcid":false,"given":"John D","family":"Rioux","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal , Quebec H3T 1J4 ,","place":["Canada"]},{"name":"Montreal Heart Institute , Montreal, Quebec H1T 1C8 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-5790","authenticated-orcid":false,"given":"Megan K","family":"Levings","sequence":"additional","affiliation":[{"name":"Department 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