{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:42:12Z","timestamp":1791207732618,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tetraspanins are a family of proteins possessing four transmembrane domains that help in lateral organization of plasma membrane proteins. These proteins interact with each other as well as other receptors and signaling proteins, resulting in functional complexes called \u201ctetraspanin microdomains.\u201d Tetraspanins, including CD82, play an essential role in the pathogenesis of fungal infections. Dectin-1, a receptor for the fungal cell wall carbohydrate \u03b2-1,3-glucan, is vital to host defense against fungal infections. The current study identifies a novel association between tetraspanin CD82 and Dectin-1 on the plasma membrane of Candida albicans\u2013containing phagosomes independent of phagocytic ability. Deletion of CD82 in mice resulted in diminished fungicidal activity, increased C. albicans viability within macrophages, and decreased cytokine production (TNF-\u03b1, IL-1\u03b2) at both mRNA and protein level in macrophages. Additionally, CD82 organized Dectin-1 clustering in the phagocytic cup. Deletion of CD82 modulates Dectin-1 signaling, resulting in a reduction of Src and Syk phosphorylation and reactive oxygen species production. CD82 knockout mice were more susceptible to C. albicans as compared with wild-type mice. Furthermore, patient C. albicans\u2013induced cytokine production was influenced by two human CD82 single nucleotide polymorphisms, whereas an additional CD82 single nucleotide polymorphism increased the risk for candidemia independent of cytokine production. Together, these data demonstrate that CD82 organizes the proper assembly of Dectin-1 signaling machinery in response to C. albicans.<\/jats:p>","DOI":"10.4049\/jimmunol.1801384","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T19:44:06Z","timestamp":1555962246000},"page":"3256-3266","source":"Crossref","is-referenced-by-count":34,"title":["Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"202","author":[{"given":"Jenny M","family":"Tam","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital , Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Reedy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital , Boston, MA 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