{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:17:17Z","timestamp":1785734237568,"version":"3.56.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, characterized by loss of tolerance toward self nuclear Ags. Systemic induction of type I IFNs plays a pivotal role in SLE, a major source of type I IFNs being the plasmacytoid dendritic cells (pDCs). Several genes have been linked with susceptibility to SLE in genome-wide association studies. We aimed at exploring the role of one such gene, \u03b1\/\u03b2-hydrolase domain-containing 6 (ABHD6), in regulation of IFN-\u03b1 induction in SLE patients. We discovered a regulatory role of ABHD6 in human pDCs through modulating the local abundance of its substrate, the endocannabinoid 2-arachidonyl glycerol (2-AG), and elucidated a hitherto unknown cannabinoid receptor 2 (CB2)\u2013mediated regulatory role of 2-AG on IFN-\u03b1 induction by pDCs. We also identified an ABHD6High SLE endophenotype wherein reduced local abundance of 2-AG relieves the CB2-mediated steady-state resistive tuning on IFN-\u03b1 induction by pDCs, thereby contributing to SLE pathogenesis.<\/jats:p>","DOI":"10.4049\/jimmunol.1801521","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T15:44:17Z","timestamp":1549467857000},"page":"1674-1679","source":"Crossref","is-referenced-by-count":21,"title":["Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype"],"prefix":"10.1093","volume":"202","author":[{"given":"Oindrila","family":"Rahaman","sequence":"first","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Division of Cancer Biology and Inflammatory Disorders, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopkatha","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Division of Cancer Biology and Inflammatory Disorders, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinky Shiu Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Division of Cancer Biology and Inflammatory Disorders, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deblina","family":"Raychaudhuri","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Division of Cancer Biology and Inflammatory Disorders, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit Raj","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Division of Cancer Biology and Inflammatory Disorders, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purbita","family":"Bandopadhyay","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Division of Cancer Biology and Inflammatory Disorders, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santu","family":"Pal","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Mass Spectrometry Core Facility, Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudra Prasad","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Postgraduate Medical Education and Research , Kolkata, West Bengal 700020 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetabali","family":"Sircar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Postgraduate Medical Education and Research , Kolkata, West Bengal 700020 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parasar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Postgraduate Medical Education and Research , Kolkata, West Bengal 700020 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-1795","authenticated-orcid":false,"given":"Dipyaman","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology\u2013Translational Research Unit of Excellence, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]},{"name":"Division of Cancer Biology and Inflammatory Disorders, Council of Scientific and Industrial Research\u2013Indian Institute of Chemical Biology , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"2025030417561230100_r1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2025030417561230100_r2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.it.2017.07.001","article-title":"Do type I interferons link systemic autoimmunities and metabolic syndrome in a pathogenetic continuum?","volume":"39","author":"Ganguly","year":"2018","journal-title":"Trends Immunol."},{"key":"2025030417561230100_r3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nri3477","article-title":"The role of dendritic cells in autoimmunity","volume":"13","author":"Ganguly","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417561230100_r4","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1084\/jem.20132522","article-title":"Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus","volume":"211","author":"Sisirak","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025030417561230100_r5","doi-asserted-by":"crossref","first-page":"ii56","DOI":"10.1136\/annrheumdis-2012-202351","article-title":"Recent insights into the genetic basis of systemic lupus erythematosus","volume":"72","author":"Rullo","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"2025030417561230100_r6","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/BOR.0000000000000205","article-title":"Advances in lupus genetics","volume":"27","author":"Niewold","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"2025030417561230100_r7","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1136\/annrheumdis-2013-204909","article-title":"PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6","volume":"74","author":"Oparina","year":"2015","journal-title":"Ann. Rheum. 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Lipid Res."},{"key":"2025030417561230100_r28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1053\/j.gastro.2016.04.015","article-title":"The role of the endocannabinoid system in the brain-gut axis","volume":"151","author":"Sharkey","year":"2016","journal-title":"Gastroenterology"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/202\/6\/1674\/61419827\/ji1801521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/202\/6\/1674\/61419827\/ji1801521.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T14:38:57Z","timestamp":1741099137000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/202\/6\/1674\/7952385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,3,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1801521","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735034414.793556609","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2019,3]]}}}