{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:45:51Z","timestamp":1770777951084,"version":"3.50.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD4 T cells express the epidermal growth factor (EGF) receptor ligand, heparin-binding EGF (HB-EGF), with no defined immuno-pathophysiological function. Therefore, we wished to elucidate the function of HB-EGF synthesized by CD4 T cells in the context of allergic pulmonary inflammation and the asthma surrogate, airway hyperresponsiveness, in a murine acute model of asthma. In this study, we show how knocking out HB-EGF expression in CD4 T cells in vivo attenuates IL-5 synthesis in the lung that is accompanied by diminished eosinophilic inflammation and airway hyperresponsiveness. HB-EGF coimmunoprecipitates with the transcriptional repressor B cell lymphoma 6 (Bcl-6) in CD4 T cells. Knocking out HB-EGF in CD4 T cells resulted in increased Bcl-6 binding to the IL-5 gene and decreased IL-5 mRNA expression. Thus, these findings suggest an immunoregulatory function for intrinsic HB-EGF expressed by CD4 T cells in TH2 inflammation and airway dysfunction by modulating IL-5 expression via binding to and inhibiting the repressive function of Bcl-6.<\/jats:p>","DOI":"10.4049\/jimmunol.1801686","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T20:15:29Z","timestamp":1558728929000},"page":"39-47","source":"Crossref","is-referenced-by-count":5,"title":["HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis"],"prefix":"10.1093","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-5870","authenticated-orcid":false,"given":"Soroor","family":"Farahnak","sequence":"first","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre , Montreal, Quebec H4A 3J1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6360-4141","authenticated-orcid":false,"given":"Leora","family":"Simon","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre , Montreal, Quebec H4A 3J1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby K","family":"McGovern","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre , Montreal, Quebec H4A 3J1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9557-4925","authenticated-orcid":false,"given":"Michael","family":"Chen","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre , Montreal, Quebec H4A 3J1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-3386","authenticated-orcid":false,"given":"Niusha","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre , Montreal, Quebec H4A 3J1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G","family":"Martin","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre , Montreal, Quebec H4A 3J1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"2025030418132851900_r1","article-title":"The other T helper cells in asthma pathogenesis","volume":"2010","author":"Vock","year":"2010","journal-title":"J. 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