{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:43:57Z","timestamp":1794350637062,"version":"4.9.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-8 is a chemokine that has been implicated in a number of inflammatory diseases involving neutrophil activation. HuMab 10F8 is a novel fully human mAb against IL-8, which binds a discontinuous epitope on IL-8 overlapping the receptor binding site, and which effectively neutralizes IL-8-dependent human neutrophil activation and migration. We investigated whether interference in the cytokine network by HuMab 10F8 might benefit patients suffering from palmoplantar pustulosis, a chronic inflammatory skin disease. Treatment of patients with HuMab 10F8 was well tolerated and significantly reduced clinical disease activity at all five endpoints, which included a \u226550% reduction in the formation of fresh pustules. IL-8 neutralization was monitored at the site of inflammation by assessing exudates of palmoplantar pustulosis lesions. HuMab 10F8 sequestered IL-8 in situ, as observed by rapid dose-dependent decreases of IL-8 concentrations immediately following Ab infusion. These data demonstrate a critical role for IL-8 in the pathophysiology of palmoplantar pustulosis. HuMab 10F8 is capable of interrupting IL-8 activity in vivo and represents a candidate for treatment of inflammatory diseases and other pathological conditions associated with IL-8 overproduction.<\/jats:p>","DOI":"10.4049\/jimmunol.181.1.669","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:04:22Z","timestamp":1397847862000},"page":"669-679","source":"Crossref","is-referenced-by-count":158,"title":["IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis"],"prefix":"10.1093","volume":"181","author":[{"given":"Lone","family":"Skov","sequence":"first","affiliation":[{"name":"Department of Dermatology, Copenhagen University Hospital Gentofte , Hellerup,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J","family":"Beurskens","sequence":"additional","affiliation":[{"name":"Genmab BV , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus O C","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Copenhagen University Hospital Gentofte , Hellerup,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakari","family":"Reitamo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Helsinki, Hospital for Skin and Allergic Diseases , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Teeling","sequence":"additional","affiliation":[{"name":"Genmab BV , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Satijn","sequence":"additional","affiliation":[{"name":"Genmab BV , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Genmab A\/S , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmieke P J","family":"Boot","sequence":"additional","affiliation":[{"name":"Genmab BV , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Hudson","sequence":"additional","affiliation":[{"name":"Medarex , Milpitas, CA 95035"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Baadsgaard","sequence":"additional","affiliation":[{"name":"Genmab A\/S , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W H I","family":"Parren","sequence":"additional","affiliation":[{"name":"Genmab BV , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G J","family":"van de Winkel","sequence":"additional","affiliation":[{"name":"Genmab BV , Utrecht,","place":["The Netherlands"]},{"name":"Immunotherapy Laboratory, Department of Immunology, University Medical Center , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"2026012807115108400_R1","first-page":"482","article-title":"Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases","volume-title":"Mol. 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