{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:32:10Z","timestamp":1790929930027,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>B lymphocyte autoimmunity plays a crucial role in the pathogenesis of rheumatoid arthritis. The local production of autoantibodies and the presence of ectopic lymphoid neogenesis in the rheumatoid synovium suggest that these dedicated microenvironments resembling canonical lymphoid follicles may regulate the initiation and maturation of B cell autoimmunity. In this study, we assessed experimentally the relevance of ectopic lymphoid neogenesis for B cell autoimmunity by a detailed structural, molecular, and serological analysis of seropositive and seronegative human synovitis. We demonstrate that synovial lymphoid neogenesis is a reversible process associated with inflammation which is neither restricted to nor preferentially associated with autoantibody positive rheumatic conditions. Despite the abundant expression of key chemokines and cytokines required for full differentiation toward germinal center reactions, synovial lymphoid neogenesis in rheumatoid arthritis only occasionally progresses toward fully differentiated follicles. In agreement with that observation, we could not detect Ag-driven clonal expansion and affinity maturation of B lymphocytes. Furthermore, ectopic lymphoid neogenesis is not directly associated with local production of anti-citrullinated protein Abs and rheumatoid factor in the rheumatoid joint. Therefore, we conclude that synovial lymphoid neogenesis is not a major determinant of these rheumatoid arthritis-specific autoantibody responses.<\/jats:p>","DOI":"10.4049\/jimmunol.181.1.785","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:04:22Z","timestamp":1397847862000},"page":"785-794","source":"Crossref","is-referenced-by-count":99,"title":["B Lymphocyte Autoimmunity in Rheumatoid Synovitis Is Independent of Ectopic Lymphoid Neogenesis"],"prefix":"10.1093","volume":"181","author":[{"given":"Tineke","family":"Cantaert","sequence":"first","affiliation":[{"name":"Clinical Immunology and Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kolln","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California Irvine , Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trieneke","family":"Timmer","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke C","family":"van der Pouw Kraan","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Vandooren","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Rheumatology"},{"name":"Internal Medicine, Ghent University Hospital , Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier M","family":"Thurlings","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Unitat d'Artritis, Servei de Reumatolog\u00eda, Hospital Cl\u00ednic de Barcelona and Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca I","family":"Catrina","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Karolinska University Hospital, Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Out","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Academic Medical Center\/University of Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cor L","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vrije Universiteit Medical Center , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California Irvine , Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P","family":"Tak","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Baeten","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"2026012807120845600_R1","first-page":"2672","article-title":"The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies.","volume-title":"J. 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