{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:21:19Z","timestamp":1771356079675,"version":"3.50.1"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In otherwise non-autoimmune-prone C57BL\/6 (B6) mice rendered genetically deficient in CD152 (CTLA-4), polyclonal hypergammaglobulinemia with increased levels of systemic lupus erythematosus (SLE)-associated IgG autoantibodies, glomerular IgG and C3 deposition, and interstitial nephritis all developed by 3\u20135 wk of age. Remarkably, superimposing genetic deficiency of BAFF (B cell-activating factor belonging to the TNF family) onto CD152 deficiency did not substantially attenuate humoral autoimmunity and immunopathology in these mice, despite the resulting marked reduction in B-lineage cells. Although superimposing a BAFF transgene (resulting in constitutive BAFF overexpression) onto CD152-deficient mice did lead to increases in B-lineage cells and serum levels of certain SLE-associated IgG autoantibodies, renal immunopathology remained largely unaffected. Taken together, these results demonstrate that global T cell dysregulation, even in an otherwise non-autoimmune-prone host, can promote systemic humoral autoimmunity and immunopathology in a BAFF-independent manner. Moreover, supraphysiologic expression of BAFF in the setting of ongoing autoimmunity does not necessarily lead to greater immunopathology. These findings may help explain the limited clinical efficacy appreciated to date of BAFF antagonists in human SLE.<\/jats:p>","DOI":"10.4049\/jimmunol.181.1.833","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:04:22Z","timestamp":1397847862000},"page":"833-841","source":"Crossref","is-referenced-by-count":15,"title":["Global T Cell Dysregulation in Non-Autoimmune-Prone Mice Promotes Rapid Development of BAFF-Independent, Systemic Lupus Erythematosus-Like Autoimmunity"],"prefix":"10.1093","volume":"181","author":[{"given":"William","family":"Stohl","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Rheumatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"William J","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P","family":"Cancro","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxin","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaim","family":"Putterman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoni","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luminita","family":"Pricop","sequence":"additional","affiliation":[{"name":"Research Division and Division of Rheumatology, Hospital for Special Surgery, Weill Medical College, Cornell University , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N","family":"Koss","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Southern California Keck School of Medicine , Los Angeles, CA 90033"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"2026012807104068200_R1","first-page":"1747","article-title":"BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.","volume-title":"J. 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