{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:07:45Z","timestamp":1789729665577,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Th17 cells, a subset of T cells involved in autoimmunity and host defense against extracellular Gram-negative infection, express both IL-17A and IL-17F. Both IL-17A and IL-17F can signal via the IL-17RA; however, IL-17F does so at a 1- to 2-log higher concentration than IL-17A. In this study, we show that the IL-17F homodimer via IL-17RA is a negative regulator of IL-17 production in T cells and suggest a mechanism whereby IL-17RA on T cells serves as an autocrine\/paracrine regulator of IL-17 synthesis in T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.181.11.7473","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:09:53Z","timestamp":1397848193000},"page":"7473-7479","source":"Crossref","is-referenced-by-count":86,"title":["Requirement of IL-17RA in Con A Induced Hepatitis and Negative Regulation of IL-17 Production in Mouse T Cells"],"prefix":"10.1093","volume":"181","author":[{"given":"Takako","family":"Nagata","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mckinley","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques J","family":"Peschon","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology , Seattle, WA 98103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shean J","family":"Aujla","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, University of Pittsburgh , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"2026012807125196700_R1","first-page":"467","article-title":"Interleukin-17 family members and inflammation","volume-title":"Immunity","year":"2004"},{"key":"2026012807125196700_R2","first-page":"233","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume-title":"J. 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