{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:37:34Z","timestamp":1775151454941,"version":"3.50.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The CD3\u03b3 di-leucine-based motif plays a central role in TCR down-regulation. However, little is understood about the role of the CD3\u03b3 di-leucine-based motif in physiological T cell responses. In this study, we show that the expansion in numbers of virus-specific CD8+ T cells is impaired in mice with a mutated CD3\u03b3 di-leucine-based motif. The CD3\u03b3 mutation did not impair early TCR signaling, nor did it compromise recruitment or proliferation of virus-specific T cells, but it increased the apoptosis rate of the activated T cells by increasing down-regulation of the antiapoptotic molecule Bcl-2. This resulted in a 2-fold reduction in the clonal expansion of virus-specific CD8+ T cells during the acute phase of vesicular stomatitis virus and lymphocytic choriomeningitis virus infections. These results identify an important role of CD3\u03b3-mediated TCR down-regulation in virus-specific CD8+ T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.181.11.7786","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:09:53Z","timestamp":1397862593000},"page":"7786-7799","source":"Crossref","is-referenced-by-count":15,"title":["TCR Down-Regulation Controls Virus-Specific CD8+ T Cell Responses"],"prefix":"10.1093","volume":"181","author":[{"given":"Charlotte Menn\u00e9","family":"Bonefeld","sequence":"first","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00eblle","family":"Haks","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"von Essen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasse","family":"Boding","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Kathrine","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeppe Madura","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"\u00d8dum","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Krimpenfort","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Kruisbeek","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Pravsgaard","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan Randrup","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"2025032719405477900_R1","first-page":"657","article-title":"Estimating the precursor frequency of naive antigen-specific CD8 T cells","volume-title":"J. 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