{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:27:20Z","timestamp":1791188840205,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-12 is essential for protective T cell-mediated immunity against Salmonella infection. To characterize the role of the related cytokine IL-23, wild-type (WT) C57BL\/6 and p19\u2212\/\u2212 mice were infected systemically with an attenuated strain of Salmonella enterica serovar Enteritidis (S. Enteritidis). IL-23-deficient mice controlled infection with S. Enteritidis similarly as WT mice. Similar IFN-\u03b3 production as compared with WT mice, but defective IL-17A and IL-22 production was found in the absence of IL-23. Nevertheless, although IL-23 is required for T cell-dependent cytokine responses, IL-23 is dispensable for protection against S. Enteritidis when IL-12 is present. To analyze the role of IL-23 in the absence of IL-12, low doses of S. Enteritidis were administered to p35\u2212\/\u2212 mice (lacking IL-12), p35\/19\u2212\/\u2212 mice (lacking IL-12 and IL-23), p35\/40\u2212\/\u2212 mice (lacking IL-12, IL-23, and homodimeric IL-12p40), or p35\/IL-17A\u2212\/\u2212 mice (lacking IL-12 and IL-17A). We found survival of p35\u2212\/\u2212 and p35\/IL-17A\u2212\/\u2212 mice, whereas p35\/19\u2212\/\u2212 and p35\/40\u2212\/\u2212 mice died within 3\u20136 wk and developed liver necrosis. This indicates that IL-23, but not homodimeric IL-12p40, is required for protection, which, surprisingly, is independent of IL-17A. Moreover, protection was associated with IL-22, but not IL-17F or IL-21 expression or with neutrophil recruitment. Finally, anti-IL-22 treatment of S. Enteritidis-infected p35\u2212\/\u2212 mice resulted in liver necrosis, indicating a central role of IL-22 in hepatocyte protection during salmonellosis. In conclusion, IL-23-dependent IL-22, but not IL-17 production is associated with protection against systemic infection with S. Enteritidis in the absence of IL-12.<\/jats:p>","DOI":"10.4049\/jimmunol.181.11.7891","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:09:53Z","timestamp":1397848193000},"page":"7891-7901","source":"Crossref","is-referenced-by-count":101,"title":["Protective Immunity to Systemic Infection with Attenuated\n                    <i>Salmonella enterica<\/i>\n                    serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17"],"prefix":"10.1093","volume":"181","author":[{"given":"Silke M","family":"Schulz","sequence":"first","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Gerhard Domagk Institute of Pathology, University of M\u00fcnster , M\u00fcnster,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Sch\u00fctze","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Knauer","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard K","family":"Straubinger","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa A","family":"Chackerian","sequence":"additional","affiliation":[{"name":"Discovery Research, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Witte","sequence":"additional","affiliation":[{"name":"Interdisciplinary Group of Molecular Immunopathology, Dermatology\/Medical Immunology, University Hospital Charit\u00e9 , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Wolk","sequence":"additional","affiliation":[{"name":"Interdisciplinary Group of Molecular Immunopathology, Dermatology\/Medical Immunology, University Hospital Charit\u00e9 , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sabat","sequence":"additional","affiliation":[{"name":"Interdisciplinary Group of Molecular Immunopathology, Dermatology\/Medical Immunology, University Hospital Charit\u00e9 , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Holscher","sequence":"additional","affiliation":[{"name":"Research Center Borstel , Borstel,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Kastelein","sequence":"additional","affiliation":[{"name":"Discovery Research, Schering-Plough Biopharma , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Alber","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"2026012807132097300_R1","first-page":"346","article-title":"IL-12 and IFN-\u03b3 in host defense against mycobacteria and salmonella in mice and men","volume-title":"Curr. Opin. Immunol.","year":"1999"},{"key":"2026012807132097300_R2","first-page":"4767","article-title":"Interleukin-12 is required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB\/c mice: role of \u03b3 interferon and macrophage activation","volume-title":"Infect. Immun.","year":"1998"},{"key":"2026012807132097300_R3","first-page":"377","article-title":"Th17 cells and mucosal host defense","volume-title":"Semin. Immunol.","year":"2007"},{"key":"2026012807132097300_R4","first-page":"739","article-title":"Typhoid fever: pathogenesis and immunologic control. 2","volume-title":"N. Engl. J. Med.","year":"1970"},{"key":"2026012807132097300_R5","first-page":"237","article-title":"Non-typhoidal salmonellosis: emerging problems","volume-title":"Microbes Infect.","year":"2001"},{"key":"2026012807132097300_R6","first-page":"5304","article-title":"IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis","volume-title":"J. Immunol.","year":"2001"},{"key":"2026012807132097300_R7","first-page":"347","article-title":"Inborn errors of IL-12\/23- and IFN-\u03b3-mediated immunity: molecular, cellular, and clinical features","volume-title":"Semin. Immunol.","year":"2006"},{"key":"2026012807132097300_R8","first-page":"393","article-title":"Immunity to systemic Salmonella infections","volume-title":"Curr. Mol. Med.","year":"2002"},{"key":"2026012807132097300_R9","first-page":"227","article-title":"Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026012807132097300_R10","first-page":"715","article-title":"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume-title":"Immunity","year":"2000"},{"key":"2026012807132097300_R11","first-page":"2202","article-title":"The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer","volume-title":"Eur. J. Immunol.","year":"1993"},{"key":"2026012807132097300_R12","first-page":"6957","article-title":"A protective and agonistic function of IL-12p40 in mycobacterial infection","volume-title":"J. Immunol.","year":"2001"},{"key":"2026012807132097300_R13","first-page":"1805","article-title":"Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2026012807132097300_R14","first-page":"557","article-title":"TGF-\u03b2, a \u201cdouble agent\u201d in the immune pathology war","volume-title":"Nat. Immunol.","year":"2006"},{"key":"2026012807132097300_R15","first-page":"329","article-title":"Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells","volume-title":"Nat. Rev. Immunol.","year":"2006"},{"key":"2026012807132097300_R16","first-page":"677","article-title":"Th17: an effector CD4 T cell lineage with regulatory T cell ties","volume-title":"Immunity","year":"2006"},{"key":"2026012807132097300_R17","first-page":"1129","article-title":"IL-17A is produced by Th17, \u03b3\u03b4 T cells and other CD4\u2212 lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance","volume-title":"Int. Immunol.","year":"2008"},{"key":"2026012807132097300_R18","first-page":"2593","article-title":"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026012807132097300_R19","first-page":"3513","article-title":"IL-17 stimulates the production and expression of proinflammatory cytokines, IL-\u03b2 and TNF-\u03b1, by human macrophages","volume-title":"J. Immunol.","year":"1998"},{"key":"2026012807132097300_R20","first-page":"5483","article-title":"Human IL-17: a novel cytokine derived from T cells","volume-title":"J. Immunol.","year":"1995"},{"key":"2026012807132097300_R21","first-page":"2347","article-title":"Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways","volume-title":"J. Immunol.","year":"1999"},{"key":"2026012807132097300_R22","first-page":"519","article-title":"Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026012807132097300_R23","first-page":"811","article-title":"Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor","volume-title":"Immunity","year":"1995"},{"key":"2026012807132097300_R24","first-page":"1","article-title":"IL-17: prototype member of an emerging cytokine family","volume-title":"J. Leukocyte Biol.","year":"2002"},{"key":"2026012807132097300_R25","first-page":"3","article-title":"Regulation of protective and pathogenic Th17 responses","volume-title":"Curr. Immunol. Rev.","year":"2007"},{"key":"2026012807132097300_R26","first-page":"454","article-title":"The biological functions of T helper 17 cell effector cytokines in inflammation","volume-title":"Immunity","year":"2008"},{"key":"2026012807132097300_R27","first-page":"624","article-title":"Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice","volume-title":"J. Infect. Dis.","year":"2004"},{"key":"2026012807132097300_R28","first-page":"4466","article-title":"Resident V\u03b41+ \u03b3\u03b4 T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production","volume-title":"J. Immunol.","year":"2007"},{"key":"2026012807132097300_R29","first-page":"78","article-title":"IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection","volume-title":"Microbes Infect.","year":"2007"},{"key":"2026012807132097300_R30","first-page":"617","article-title":"Interleukin-17\/Interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection","volume-title":"Infect. Immun.","year":"2005"},{"key":"2026012807132097300_R31","first-page":"744","article-title":"Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain","volume-title":"Nature","year":"2003"},{"key":"2026012807132097300_R32","first-page":"233","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2026012807132097300_R33","first-page":"1951","article-title":"Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026012807132097300_R34","first-page":"1310","article-title":"IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6","volume-title":"J. Clin. Invest.","year":"2006"},{"key":"2026012807132097300_R35","first-page":"467","article-title":"Interleukin-17 family members and inflammation","volume-title":"Immunity","year":"2004"},{"key":"2026012807132097300_R36","first-page":"1123","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume-title":"Nat. Immunol.","year":"2005"},{"key":"2026012807132097300_R37","first-page":"349","article-title":"Expanding the effector CD4 T-cell repertoire: the Th17 lineage","volume-title":"Curr. Opin. Immunol.","year":"2006"},{"key":"2026012807132097300_R38","first-page":"443","article-title":"New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25","volume-title":"J. Immunol.","year":"2002"},{"key":"2026012807132097300_R39","first-page":"12","article-title":"Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response","volume-title":"Am. J. Respir. Crit. Care Med.","year":"2005"},{"key":"2026012807132097300_R40","first-page":"2271","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2026012807132097300_R41","first-page":"648","article-title":"Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis","volume-title":"Nature","year":"2007"},{"key":"2026012807132097300_R42","first-page":"10144","article-title":"Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026012807132097300_R43","first-page":"1814","article-title":"Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9","volume-title":"J. Immunol.","year":"2000"},{"key":"2026012807132097300_R44","first-page":"5397","article-title":"Cutting edge: immune cells as sources and targets of the IL-10 family members?","volume-title":"J. Immunol.","year":"2002"},{"key":"2026012807132097300_R45","first-page":"241","article-title":"IL-22 increases the innate immunity of tissues","volume-title":"Immunity","year":"2004"},{"key":"2026012807132097300_R46","first-page":"10144","article-title":"Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026012807132097300_R47","first-page":"5973","article-title":"IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn\u2019s disease","volume-title":"J. Immunol.","year":"2007"},{"key":"2026012807132097300_R48","first-page":"969","article-title":"Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts","volume-title":"Gastroenterology","year":"2005"},{"key":"2026012807132097300_R49","first-page":"309","article-title":"Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis","volume-title":"Eur. Cytokine Network","year":"2005"},{"key":"2026012807132097300_R50","first-page":"G827","article-title":"IL-22 is increased in active Crohn\u2019s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration","volume-title":"Am. J. Physiol.","year":"2006"},{"key":"2026012807132097300_R51","first-page":"1037","article-title":"Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine","volume-title":"Arthritis Rheum.","year":"2005"},{"key":"2026012807132097300_R52","first-page":"1309","article-title":"IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis","volume-title":"Eur. J. Immunol.","year":"2006"},{"key":"2026012807132097300_R53","first-page":"43","article-title":"Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3","volume-title":"Cell. Mol. Immunol.","year":"2004"},{"key":"2026012807132097300_R54","first-page":"1332","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume-title":"Hepatology","year":"2004"},{"key":"2026012807132097300_R55","first-page":"647","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume-title":"Immunity","year":"2007"},{"key":"2026012807132097300_R56","first-page":"367","article-title":"Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells","volume-title":"Cytokine Growth Factor Rev.","year":"2006"},{"key":"2026012807132097300_R57","first-page":"471","article-title":"IL-12-deficient mice are defective in IFN\u03b3 production and type 1 cytokine responses","volume-title":"Immunity","year":"1996"},{"key":"2026012807132097300_R58","first-page":"1553","article-title":"Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2026012807132097300_R59","first-page":"6092","article-title":"Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection","volume-title":"Infect. Immun.","year":"2006"},{"key":"2026012807132097300_R60","first-page":"375","article-title":"Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses","volume-title":"Immunity","year":"2002"},{"key":"2026012807132097300_R61","first-page":"246","article-title":"A new live Salmonella enteritidis vaccine for chickens: experimental evidence of its safety and efficacy","volume-title":"Berl. Munch. Tierarztl. Wochenschr.","year":"2000"},{"key":"2026012807132097300_R62","first-page":"369","article-title":"Immunization with potential Salmonella enteritidis mutants. 2. Investigations on the attenuation and immunogenicity for mice and young hens","volume-title":"Berl. Munch. Tierarztl. Wochenschr.","year":"1996"},{"key":"2026012807132097300_R63","first-page":"4779","article-title":"Immunity induced with a Salmonella enterica serovar Enteritidis live vaccine is regulated by Th1-cell-dependent cellular and humoral effector mechanisms in susceptible BALB\/c mice","volume-title":"Vaccine","year":"2006"},{"key":"2026012807132097300_R64","first-page":"259","article-title":"Chemiluminescence and nitrite determinations by the MALU macrophage cell line","volume-title":"J. Immunol. Methods","year":"1994"},{"key":"2026012807132097300_R65","first-page":"991","article-title":"Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs","volume-title":"Exp. Dermatol.","year":"2006"},{"key":"2026012807132097300_R66","first-page":"1133","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume-title":"Nat. Immunol.","year":"2005"},{"key":"2026012807132097300_R67","first-page":"1910","article-title":"Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17","volume-title":"J. Biol. Chem.","year":"2003"},{"key":"2026012807132097300_R68","first-page":"788","article-title":"IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-\u03b3 responses if IL-12p70 is available","volume-title":"J. Immunol.","year":"2005"},{"key":"2026012807132097300_R69","first-page":"1887","article-title":"IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012807132097300_R70","first-page":"87","article-title":"Th17 cells: a new fate for differentiating helper T cells","volume-title":"Immunol. Res.","year":"2008"},{"key":"2026012807132097300_R71","first-page":"49","article-title":"Elevated neutrophil, macrophage and dendritic cell numbers characterize immune cell populations in mice chronically infected with Salmonella","volume-title":"Microb. Pathog.","year":"2006"},{"key":"2026012807132097300_R72","first-page":"6383","article-title":"IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines","volume-title":"J. Immunol.","year":"1998"},{"key":"2026012807132097300_R73","first-page":"1962","article-title":"Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response","volume-title":"J. Immunol.","year":"2008"},{"key":"2026012807132097300_R74","first-page":"275","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia","volume-title":"Nat. Med.","year":"2008"},{"key":"2026012807132097300_R75","first-page":"282","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume-title":"Nat. Med.","year":"2008"},{"key":"2026012807132097300_R76","first-page":"421","article-title":"Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut","volume-title":"Nat. Med.","year":"2008"},{"key":"2026012807132097300_R77","first-page":"282","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume-title":"Nat. Med.","year":"2008"},{"key":"2026012807132097300_R78","first-page":"282","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume-title":"Nat. Med.","year":"2008"},{"key":"2026012807132097300_R79","first-page":"7880","article-title":"General nature of the STAT3-activated anti-inflammatory response","volume-title":"J. Immunol.","year":"2006"},{"key":"2026012807132097300_R80","first-page":"231","article-title":"Transforming growth factor-\u03b2 induces development of the TH17 lineage","volume-title":"Nature","year":"2006"},{"key":"2026012807132097300_R81","first-page":"1755","article-title":"Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans","volume-title":"J. Infect. Dis.","year":"2004"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/181\/11\/7891\/62724765\/8142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/181\/11\/7891\/62724765\/8142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:16:10Z","timestamp":1769602570000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/181\/11\/7891\/8009149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,1]]},"references-count":81,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2008,12,1]]},"published-print":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.181.11.7891","relation":{},"ISSN":["1550-6606","0022-1767"],"issn-type":[{"value":"1550-6606","type":"electronic"},{"value":"0022-1767","type":"print"}],"subject":[],"published-other":{"date-parts":[[2008,12]]},"published":{"date-parts":[[2008,12,1]]}}}