{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:42:39Z","timestamp":1791121359837,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endogenous danger signals released from necrotic cells are thought to be sensed by phagocytes leading to secretion of IL-1\u03b1 and neutrophilic recruitment. However, the mechanisms for IL-1\u03b1 production and IL-1\u03b1-mediated sterile inflammation remain poorly understood. We report here that necrotic cell extracts elicited little secretion of CXCL1 and IL-6 from macrophages but robust production in mesothelial cells. The induction of CXCL1 as well as activation of NF-\u03baB and MAPKs by cytosolic extracts required the presence of IL-1\u03b1 in the necrotic cell. Conversely, expression of IL-1R and MyD88 but not IL-1\u03b1, RICK, TLR2, TLR4, TRIF, or inflammasome components in mesothelial cells was critical for the production of CXCL1. Furthermore, IL-1\u03b1 was critical to induce the recruitment of neutrophils in the peritoneal cavity via CXCR2. These studies show that IL-1\u03b1 is a key danger signal released from necrotic cells to trigger CXCL1 secretion and recruitment of neutrophils via IL-1R\/MyD88 on neighboring mesothelial cells.<\/jats:p>","DOI":"10.4049\/jimmunol.181.12.8194","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:24:21Z","timestamp":1397849061000},"page":"8194-8198","source":"Crossref","is-referenced-by-count":203,"title":["Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1\u03b1 Released from Dying Cells"],"prefix":"10.1093","volume":"181","author":[{"given":"Tatjana","family":"Eigenbrod","sequence":"first","affiliation":[{"name":"Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Center for Medical Science, Institute of Medical Science, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"2025032719420220400_R1","first-page":"783","article-title":"Pathogen recognition and innate immunity","volume-title":"Cell","year":"2006"},{"key":"2025032719420220400_R2","first-page":"355","article-title":"NOD-LRR proteins: role in host-microbial interactions and inflammatory disease","volume-title":"Annu. 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