{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:37:48Z","timestamp":1790807868340,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fusobacterium necrophorum subspecies funduliforme is an obligate anaerobic Gram-negative rod causing invasive infections such as the life-threatening Lemierre\u2019s syndrome (sore throat, septicemia, jugular vein thrombosis, and disseminated infection). The aim of our study was to understand if and how F. necrophorum avoids C activation. We studied 12 F. necrophorum subsp. funduliforme strains isolated from patients with sepsis. All strains were resistant to serum killing after a 1-h incubation in 20% serum. The bacteria bound, at different levels, the C inhibitor factor H (fH). Binding was ionic and specific in nature and occurred via sites on both the N terminus and the C terminus of fH. Bound fH remained functionally active as a cofactor for factor I in the cleavage of C3b. Interestingly, patients with the most severe symptoms carried strains with the strongest ability to bind fH. An increased C3b deposition and membrane attack complex formation on the surface of a weakly fH-binding strain was observed and its survival in serum at 3.5 h was impaired. This strain had not caused a typical Lemierre\u2019s syndrome. These data, and the fact that fH-binding correlated with the severity of disease, suggest that the binding of fH contributes to virulence and survival of F. necrophorum subsp. funduliforme in the human host. Our data show, for the first time, that an anaerobic bacterium is able to bind the C inhibitor fH to evade C attack.<\/jats:p>","DOI":"10.4049\/jimmunol.181.12.8624","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:24:21Z","timestamp":1397863461000},"page":"8624-8632","source":"Crossref","is-referenced-by-count":35,"title":["Factor H Binding as a Complement Evasion Mechanism for an Anaerobic Pathogen, <i>Fusobacterium necrophorum<\/i>"],"prefix":"10.1093","volume":"181","author":[{"given":"Nathalie","family":"Friberg","sequence":"first","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petteri","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna","family":"Kentala","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri S","family":"Mattila","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pentti","family":"Kuusela","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki ,","place":["Finland"]},{"name":"HUSLAB, Helsinki University Central Hospital ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Meri","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki ,","place":["Finland"]},{"name":"HUSLAB, Helsinki University Central Hospital ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Jarva","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki ,","place":["Finland"]},{"name":"HUSLAB, Helsinki University Central Hospital ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"2025032719413316000_R1","first-page":"299","article-title":"Fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and Lemierre\u2019s disease","volume-title":"J. 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