{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:35:22Z","timestamp":1790523322475,"version":"4.1.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sarcoidosis is a systemic granulomatous disease associated with local epithelioid granulomas, CD4+ T cells, and Th1 cytokines. The tissue Ags that drive this granulomatous inflammation are uncertain. In this study, we used IFN-\u03b3-ELISPOT assays and flow cytometry to assess lung and blood T cell responses to the candidate pathogenic Ag, Mycobacterium tuberculosis catalase-peroxidase (mKatG) in patients with sarcoidosis from two centers. Despite differences in patient phenotypic, genetic, and prognostic characteristics, we report that T cell responses to mKatG were remarkably similar in these cohorts, with higher frequencies of mKatG-reactive, IFN-\u03b3-expressing T cells in the blood of sarcoidosis patients compared with nontuberculosis sensitized healthy controls, and (in a subset) in greater numbers than T cells reactive to purified protein derivative. In sarcoidosis, mKatG-reactive CD4+ Th1 cells preferentially accumulated in the lung, indicating a compartmentalized response. Patients with or without L\u00f6fgren syndrome had similar frequencies of mKatG specific IFN-\u03b3-expressing blood T cells. Circulating mKatG-reactive T cells were found in chronic active sarcoidosis but not in patients with inactive disease. Together, these results demonstrate that T cell responses to mKatG in sarcoidosis fit a profile expected for a pathogenic Ag, supporting an immunotherapeutic approach to this disease.<\/jats:p>","DOI":"10.4049\/jimmunol.181.12.8784","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:24:21Z","timestamp":1397863461000},"page":"8784-8796","source":"Crossref","is-referenced-by-count":144,"title":["T Cell Responses to Mycobacterial Catalase-Peroxidase Profile a Pathogenic Antigen in Systemic Sarcoidosis"],"prefix":"10.1093","volume":"181","author":[{"given":"Edward S","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Department of Medicine at Karolinska University Hospital and Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H","family":"Willett","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Wik\u00e9n","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Department of Medicine at Karolinska University Hospital and Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex C","family":"Yung","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E","family":"West","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"McDyer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, The Johns Hopkins University Bloomberg School of Public Health , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Eklund","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Department of Medicine at Karolinska University Hospital and Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Grunewald","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Department of Medicine at Karolinska University Hospital and Karolinska Institutet , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Moller","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"2025032719413037300_R1","first-page":"736","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1999"},{"key":"2025032719413037300_R2","first-page":"40","article-title":"Sex-specific manifestations of Lofgren\u2019s syndrome","volume-title":"Am. J. Respir. Crit. Care Med.","year":"2007"},{"key":"2025032719413037300_R3","first-page":"22","article-title":"Epidemiology of sarcoidosis: recent advances and future prospects","volume-title":"Semin. Respir. Crit. Care Med.","year":"2007"},{"key":"2025032719413037300_R4","first-page":"1885","article-title":"Clinical characteristics of patients in a case control study of sarcoidosis","volume-title":"Am. J. Respir. Crit. Care Med.","year":"2001"},{"key":"2025032719413037300_R5","first-page":"3","article-title":"Sarcoidosis: immunopathogenetic concepts","volume-title":"Semin. Respir. Crit. Care Med.","year":"2007"},{"key":"2025032719413037300_R6","first-page":"429","article-title":"Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity","volume-title":"N. Engl. J. Med.","year":"1981"},{"key":"2025032719413037300_R7","first-page":"1488","article-title":"\u03b3 interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis","volume-title":"J. Clin. Invest.","year":"1985"},{"key":"2025032719413037300_R8","first-page":"4952","article-title":"Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis","volume-title":"J. Immunol.","year":"1996"},{"key":"2025032719413037300_R9","first-page":"3926","article-title":"Antibodies to the IL-12 receptor \u03b2 2 chain mark human Th1 but not Th2 cells in vitro and in vivo","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032719413037300_R10","first-page":"4718","article-title":"Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis","volume-title":"J. Immunol.","year":"2000"},{"key":"2025032719413037300_R11","first-page":"564","article-title":"Expression of Th1 markers by lung accumulated T cells in pulmonary sarcoidosis","volume-title":"J. Intern. Med.","year":"2003"},{"key":"2025032719413037300_R12","first-page":"106","article-title":"Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"2003"},{"key":"2025032719413037300_R13","first-page":"376","article-title":"Recurrence of sarcoidosis following interferon \u03b1 therapy for chronic hepatitis C","volume-title":"Intern. Med.","year":"1996"},{"key":"2025032719413037300_R14","first-page":"2009","article-title":"Sarcoid-like pulmonary disorder in human immunodeficiency virus-infected patients receiving antiretroviral therapy","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1999"},{"key":"2025032719413037300_R15","first-page":"365","article-title":"Etiology of sarcoidosis","volume-title":"Clin. Chest Med.","year":"2008"},{"key":"2025032719413037300_R16","first-page":"174","article-title":"Involvement of T cells and alterations in T cell receptors in sarcoidosis","volume-title":"Semin. Respir. Infect.","year":"1998"},{"key":"2025032719413037300_R17","first-page":"1183","article-title":"Bias toward use of a specific T cell receptor \u03b2-chain variable region in a subgroup of individuals with sarcoidosis","volume-title":"J. Clin. Invest.","year":"1988"},{"key":"2025032719413037300_R18","first-page":"129","article-title":"Restricted V \u03b1 2.3 gene usage by CD4+ T lymphocytes in bronchoalveolar lavage fluid from sarcoidosis patients correlates with HLA-DR3","volume-title":"Eur. J. Immunol.","year":"1992"},{"key":"2025032719413037300_R19","first-page":"4291","article-title":"TCR expression of activated T cell clones in the lungs of patients with pulmonary sarcoidosis","volume-title":"J. Immunol.","year":"1994"},{"key":"2025032719413037300_R20","first-page":"287","article-title":"Restricted usage of T cell receptor V\u03b1\/J\u03b1 gene segments with different nucleotide but identical amino acid sequences in HLA-DR3+ sarcoidosis patients","volume-title":"Mol. Med.","year":"1995"},{"key":"2025032719413037300_R21","first-page":"516","article-title":"Limited heterogeneity of biased T-cell receptor V\u03b2 gene usage in lung but not blood T cells in active pulmonary sarcoidosis","volume-title":"Immunology","year":"1996"},{"key":"2025032719413037300_R22","first-page":"755","article-title":"Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2025032719413037300_R23","first-page":"508","article-title":"Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis","volume-title":"Eur. Respir. J.","year":"2007"},{"key":"2025032719413037300_R24","first-page":"197","article-title":"The role of mycobacteria in the pathogenesis of sarcoidosis","volume-title":"Semin. Respir. Infect.","year":"1998"},{"key":"2025032719413037300_R25","first-page":"527","article-title":"Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis","volume-title":"Infect. Immun.","year":"2007"},{"key":"2025032719413037300_R26","first-page":"445","article-title":"Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis","volume-title":"J. Clin. Immunol.","year":"2007"},{"key":"2025032719413037300_R27","first-page":"346","article-title":"Mycobacterial heat shock protein-induced blood T lymphocytes subsets and cytokine pattern: comparison of sarcoidosis with tuberculosis and healthy controls","volume-title":"Respirology","year":"2007"},{"key":"2025032719413037300_R28","first-page":"624","article-title":"Third WASOG meeting, Los Angeles, USA, September 8\u201311, 1993","volume-title":"Eur. Respir. J.","year":"1994"},{"key":"2025032719413037300_R29","first-page":"1","article-title":"American Thoracic Society","volume-title":"MMWR Recomm. Rep.","year":"2000"},{"key":"2025032719413037300_R30","first-page":"451","article-title":"Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis","volume-title":"Eur. Respir. J.","year":"2006"},{"key":"2025032719413037300_R31","first-page":"591","article-title":"The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis","volume-title":"Nature","year":"1992"},{"key":"2025032719413037300_R32","first-page":"2834","article-title":"Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis","volume-title":"J. Biol. Chem.","year":"1997"},{"key":"2025032719413037300_R33","first-page":"4965","article-title":"T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1994"},{"key":"2025032719413037300_R34","first-page":"1533","article-title":"Selective activation and accumulation of oligoclonal V\u03b2-specific T cells in active pulmonary sarcoidosis","volume-title":"J. Clin. Invest.","year":"1994"},{"key":"2025032719413037300_R35","first-page":"629","article-title":"Relationship between changed alveolar-capillary permeability and angiotensin converting enzyme activity in serum in sarcoidosis","volume-title":"Thorax","year":"1986"},{"key":"2025032719413037300_R36","first-page":"2017","article-title":"Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells","volume-title":"Lancet","year":"2001"},{"key":"2025032719413037300_R37","first-page":"2625","article-title":"Persistent cytomegalovirus-specific memory responses in the lung allograft and blood following primary infection in lung transplant recipients","volume-title":"J. Immunol.","year":"2006"},{"key":"2025032719413037300_R38","first-page":"5.4.1","article-title":"Flow cytometry analysis using the Becton Dickinson FACS Calibur. J. E. Coligan, Jr, and B. E. Bierer, Jr, and D. H. Margulies, Jr, and E. M. Shevach, Jr, and W. Strober, Jr, eds","volume-title":"Current Protocols in Immunology","year":"2002"},{"key":"2025032719413037300_R39","first-page":"861","article-title":"Antigen-induced proliferative response of lavage and blood T lymphocytes: comparison of cells from normal subjects and patients with sarcoidosis","volume-title":"Am. Rev. Respir. Dis.","year":"1991"},{"key":"2025032719413037300_R40","first-page":"391","article-title":"Expression of surface antigens distinguishing \u201cnaive\u201d and previously activated lymphocytes in bronchoalveolar lavage fluid","volume-title":"Thorax","year":"1990"},{"key":"2025032719413037300_R41","first-page":"814","article-title":"Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical features of pulmonary sarcoidosis","volume-title":"Am. J. Respir. Crit. Care Med.","year":"2000"},{"key":"2025032719413037300_R42","first-page":"165","article-title":"Analysis of responses of peripheral blood lymphocytes from sarcoidosis patients to purified protein derivative","volume-title":"Jpn. J. Ophthalmol.","year":"2000"},{"key":"2025032719413037300_R43","first-page":"535","article-title":"Comparison of antigen-specific T-cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis","volume-title":"Scand. J. Immunol.","year":"1998"},{"key":"2025032719413037300_R44","first-page":"3034","article-title":"Cytokine patterns in tuberculous and sarcoid granulomas: correlations with histopathologic features of the granulomatous response","volume-title":"J. Immunol.","year":"1997"},{"key":"2025032719413037300_R45","first-page":"301","article-title":"Strain variation in the katG region of Mycobacterium tuberculosis","volume-title":"Mol. Microbiol.","year":"1994"},{"key":"2025032719413037300_R46","first-page":"5","article-title":"Cell damage and autoimmunity: a critical appraisal","volume-title":"J. Autoimmun.","year":"2008"},{"key":"2025032719413037300_R47","first-page":"117","article-title":"Recruitment of antigen-specific Th1-like responses to the human lung following bronchoscopic segmental challenge with purified protein derivative of Mycobacterium tuberculosis","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"2003"},{"key":"2025032719413037300_R48","first-page":"1410","article-title":"Lymphocyte recruitment and protective efficacy against pulmonary mycobacterial infection are independent of the route of prior Mycobacterium bovis BCG immunization","volume-title":"Infect. Immun.","year":"2002"},{"key":"2025032719413037300_R49","first-page":"5","article-title":"The role of infection in the pathogenesis of autoimmune disease","volume-title":"Semin. Immunol.","year":"1998"},{"key":"2025032719413037300_R50","first-page":"5217","article-title":"Direct ex vivo analysis of antigen-specific IFN-\u03b3-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment","volume-title":"J. Immunol.","year":"2001"},{"key":"2025032719413037300_R51","first-page":"4729","article-title":"Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays","volume-title":"J. Immunol.","year":"2001"},{"key":"2025032719413037300_R52","first-page":"2210","article-title":"Evolution of epitope-specific memory CD4+ T cells after clearance of hepatitis C virus","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032719413037300_R53","first-page":"326","article-title":"Understanding the generation and function of memory T cell subsets","volume-title":"Curr. Opin. Immunol.","year":"2005"},{"key":"2025032719413037300_R54","first-page":"509","article-title":"Increased CD45RO expression on T lymphocytes in mediastinal lymph node and pulmonary lesions of patients with pulmonary sarcoidosis","volume-title":"Clin. Exp. Immunol.","year":"1994"},{"key":"2025032719413037300_R55","first-page":"2886","article-title":"Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response","volume-title":"J. Clin. Invest.","year":"2005"},{"key":"2025032719413037300_R56","first-page":"430","article-title":"In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis","volume-title":"Clin. Exp. Immunol.","year":"1983"},{"key":"2025032719413037300_R57","first-page":"1722","article-title":"Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis","volume-title":"Infect. Immun.","year":"2001"},{"key":"2025032719413037300_R58","first-page":"293","article-title":"The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis","volume-title":"J. Immunol.","year":"1987"},{"key":"2025032719413037300_R59","first-page":"2037","article-title":"Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells","volume-title":"Infect. Immun.","year":"1987"},{"key":"2025032719413037300_R60","first-page":"290","article-title":"Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis","volume-title":"J. Immunol.","year":"1997"},{"key":"2025032719413037300_R61","first-page":"1623","article-title":"Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8+- and CD4+-T-cell epitopes from antigen 85A","volume-title":"Infect. Immun.","year":"2002"},{"key":"2025032719413037300_R62","first-page":"1473","article-title":"Target organ localization of memory CD4+ T cells in patients with chronic beryllium disease","volume-title":"J. Clin. Invest.","year":"2002"},{"key":"2025032719413037300_R63","first-page":"334","article-title":"Restraining mycobacteria: role of granulomas in mycobacterial infections","volume-title":"Immunol. Cell Biol.","year":"2000"},{"key":"2025032719413037300_R64","first-page":"23","article-title":"Expression and immune recognition of stress proteins in sarcoidosis and other chronic interstitial lung diseases","volume-title":"Immunol. Cell Biol.","year":"1995"},{"key":"2025032719413037300_R65","first-page":"828","article-title":"Superinfecting mycobacteria home to established tuberculous granulomas","volume-title":"Nat. Immunol.","year":"2004"},{"key":"2025032719413037300_R66","first-page":"1993","article-title":"T cell memory. Long-term persistence of virus-specific cytotoxic T cells","volume-title":"J. Exp. Med.","year":"1989"},{"key":"2025032719413037300_R67","first-page":"407","article-title":"CD4 T-cell memory can persist in the absence of class II","volume-title":"Philos. Trans. R. Soc. London B","year":"2000"},{"key":"2025032719413037300_R68","first-page":"4882","article-title":"CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype","volume-title":"Blood","year":"2007"},{"key":"2025032719413037300_R69","first-page":"15","article-title":"Genetics of sarcoidosis","volume-title":"Semin. Respir. Crit. Care Med.","year":"2007"},{"key":"2025032719413037300_R70","first-page":"187","article-title":"Tuberculosis in patients with various HLA phenotypes","volume-title":"Tubercle","year":"1990"},{"key":"2025032719413037300_R71","first-page":"3800","article-title":"In vitro expansion of T-cell-receptor V\u03b12.3+ CD4+ T lymphocytes in HLA-DR17(3), DQ2+ individuals upon stimulation with Mycobacterium tuberculosis","volume-title":"Infect. Immun.","year":"1999"},{"key":"2025032719413037300_R72","first-page":"3576","article-title":"Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis","volume-title":"J. Clin. Invest.","year":"2007"},{"key":"2025032719413037300_R73","first-page":"1586","article-title":"Sarcoidosis: TNF-\u03b1 release from alveolar macrophages and serum level of sIL-2R are prognostic markers","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1997"},{"key":"2025032719413037300_R74","first-page":"1123","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume-title":"Nat Immunol.","year":"2005"},{"key":"2025032719413037300_R75","first-page":"1051","article-title":"Induction and effector functions of TH17 cells","volume-title":"Nature","year":"2008"},{"key":"2025032719413037300_R76","first-page":"1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor \u03b1-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume-title":"J. Immunol.","year":"1995"},{"key":"2025032719413037300_R77","first-page":"737","article-title":"A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis","volume-title":"Nature","year":"1997"},{"key":"2025032719413037300_R78","first-page":"782","article-title":"Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression","volume-title":"Nat. Med.","year":"2000"},{"key":"2025032719413037300_R79","first-page":"359","article-title":"The immune paradox of sarcoidosis and regulatory T cells","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2025032719413037300_R80","first-page":"127","article-title":"Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis","volume-title":"Clin. Exp. 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