{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:39Z","timestamp":1787030859900,"version":"build-2736575974"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously reported that the lack of serglycin proteoglycan affects secretory granule morphology and granzyme B (GrB) storage in in vitro generated CTLs. In this study, the role of serglycin during viral infection was studied by infecting wild-type (wt) mice and serglycin-deficient (SG\u2212\/\u2212) mice with lymphocytic choriomeningitis virus (LCMV). Wt and SG\u2212\/\u2212 mice cleared 103 PFU of highly invasive LCMV with the same kinetics, and the CD8+ T lymphocytes from wt and SG\u2212\/\u2212 animals did not differ in GrB, perforin, IFN-\u03b3, or TNF-\u03b1 content. However, when a less invasive LCMV strain was used, SG\u2212\/\u2212 GrB+ CD8+ T cells contained \u223c30% less GrB than wt GrB+ CD8+ T cells. Interestingly, the contraction of the antiviral CD8+ T cell response to highly invasive LCMV was markedly delayed in SG\u2212\/\u2212 mice, and a delayed contraction of the virus-specific CD8+ T cell response was also seen after infection with vesicular stomatitis virus. BrdU labeling of cells in vivo revealed that the delayed contraction was associated with sustained proliferation of Ag-specific CD8+ T cells in SG\u2212\/\u2212 mice. Moreover, wt LCMV-specific CD8+ T cells from TCR318 transgenic mice expanded much more extensively in virus-infected SG\u2212\/\u2212 mice than in matched wt mice, indicating that the delayed contraction represents a T cell extrinsic phenomenon. In summary, the present report points to a novel, previously unrecognized role for serglycin proteoglycan in regulating the kinetics of antiviral CD8+ T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.181.2.1043","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:27:05Z","timestamp":1397849225000},"page":"1043-1051","source":"Crossref","is-referenced-by-count":24,"title":["Delayed Contraction of the CD8+ T Cell Response toward Lymphocytic Choriomeningitis Virus Infection in Mice Lacking Serglycin"],"prefix":"10.1093","volume":"181","author":[{"given":"Mirjana","family":"Grujic","sequence":"first","affiliation":[{"name":"University of Copenhagen, Institute of International Health, Immunology and Microbiology , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P","family":"Christensen","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Institute of International Health, Immunology and Microbiology , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Institute of International Health, Immunology and Microbiology , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Abrink","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Uppsala University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Pejler","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan R","family":"Thomsen","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Institute of International Health, Immunology and Microbiology , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,7,15]]},"reference":[{"key":"2026012807113752500_R1","first-page":"82","article-title":"Three-dimensional segregation of supramolecular activation clusters in T cells","volume-title":"Nature","year":"1998"},{"key":"2026012807113752500_R2","first-page":"751","article-title":"The immunological synapse of CTL contains a secretory domain and membrane bridges","volume-title":"Immunity","year":"2001"},{"key":"2026012807113752500_R3","first-page":"87","article-title":"CTL secretory lysosomes: biogenesis and secretion of a harmful organelle","volume-title":"Semin. 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