{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:36:40Z","timestamp":1790001400911,"version":"4.0.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>EBV is a candidate trigger of rheumatoid arthritis (RA). We determined both EBV-specific T cell and B cell responses and cell-associated EBV DNA copies in patients with RA and demographically matched healthy virus carriers. Patients with RA showed increased and broadened IgG responses to lytic and latent EBV-encoded Ags and 7-fold higher levels of EBV copy numbers in circulating blood cells. Additionally, patients with RA exhibited substantial expansions of CD8+ T cells specific for pooled EBV Ags expressed during both B cell transformation and productive viral replication and the frequency of CD8+ T cells specific for these Ags correlated with cellular EBV copy numbers. In contrast, CD4+ T cell responses to EBV and T cell responses to human CMV Ags were unchanged, altogether arguing against a defective control of latent EBV infection in RA. Our data show that the regulation of EBV infection is perturbed in RA and suggest that increased EBV-specific effector T cell and Ab responses are driven by an elevated EBV load in RA.<\/jats:p>","DOI":"10.4049\/jimmunol.181.2.991","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:27:05Z","timestamp":1397849225000},"page":"991-1000","source":"Crossref","is-referenced-by-count":56,"title":["Increased Frequency of EBV-Specific Effector Memory CD8+ T Cells Correlates with Higher Viral Load in Rheumatoid Arthritis"],"prefix":"10.1093","volume":"181","author":[{"given":"Jan D","family":"L\u00fcnemann","sequence":"first","affiliation":[{"name":"Laboratory of Viral Immunobiology, Christopher H. Browne Center for Immunology and Immune Diseases, Rockefeller University , New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Frey","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Immunologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Eidner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Baier","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mik-robiologie, Universit\u00e4tsklinikum Jena , Jena,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Roberts","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Immunobiology, Christopher H. Browne Center for Immunology and Immune Diseases, Rockefeller University , New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Sashihara","sequence":"additional","affiliation":[{"name":"Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Volkmer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Immunologie, Charit\u00e8 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I","family":"Cohen","sequence":"additional","affiliation":[{"name":"Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Hein","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kamradt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Immunologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00fcnz","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Immunobiology, Christopher H. 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