{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:52:13Z","timestamp":1792122733858,"version":"4.4.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>MHC class I molecules and \u03b22-microglobulin (\u03b22m) are membrane glycoproteins that present peptide Ags to TCRs, and bind to inhibitory and activating receptors on NK cells and other leukocytes. They are involved in the discrimination of self from non-self. Modification of these molecules in the placenta benefits pregnancy, but little is known about their genes in the uterus. We examined the classical class I swine leukocyte Ags (SLA) genes SLA-1, SLA-2, and SLA-3, the nonclassical SLA-6, SLA-7, and SLA-8 genes, and the \u03b22m gene in pig uterus during pregnancy. Uterine SLA and \u03b22m increased in luminal epithelium between days 5 and 9, then decreased between days 15 and 20. By day 15 of pregnancy, SLA and \u03b22m increased in stroma and remained detectable through day 40. To determine effects of estrogens, which are secreted by conceptuses to prevent corpus luteum regression, nonpregnant pigs were treated with estradiol benzoate, which did not affect the SLA or \u03b22m genes. In contrast, progesterone, which is secreted by corpora lutea, increased SLA and \u03b22m in luminal epithelium, whereas a progesterone receptor antagonist (ZK137,316) ablated this up-regulation. To determine effects of conceptus secretory proteins (CSP) containing IFN-\u03b4 and IFN-\u03b3, nonpregnant pigs were implanted with mini-osmotic pumps that delivered CSP to uterine horns. CSP increased SLA and \u03b22m in stroma. Cell-type specific regulation of SLA and \u03b22m genes by progesterone and IFNs suggests that placental secretions control expression of immune regulatory molecules on uterine cells to provide an immunologically favorable environment for survival of the fetal-placental semiallograft.<\/jats:p>","DOI":"10.4049\/jimmunol.181.4.2494","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:08:31Z","timestamp":1397848111000},"page":"2494-2505","source":"Crossref","is-referenced-by-count":68,"title":["Uterine MHC Class I Molecules and \u03b22-Microglobulin Are Regulated by Progesterone and Conceptus Interferons during Pig Pregnancy"],"prefix":"10.1093","volume":"181","author":[{"given":"Margaret M","family":"Joyce","sequence":"first","affiliation":[{"name":"Center for Animal Biotechnology and Genomics"},{"name":"Department of Veterinary Integrative Bioscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R","family":"Burghardt","sequence":"additional","affiliation":[{"name":"Center for Animal Biotechnology and Genomics"},{"name":"Department of Veterinary Integrative Bioscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Burghardt","sequence":"additional","affiliation":[{"name":"Center for Animal Biotechnology and Genomics"},{"name":"Department of Veterinary Integrative Bioscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Neil","family":"Hooper","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W","family":"Bazer","sequence":"additional","affiliation":[{"name":"Center for Animal Biotechnology and Genomics"},{"name":"Department of Animal Science, College of Agriculture and Life Sciences, Texas A&M University , College Station, TX 77843-4458"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Center for Animal Biotechnology and Genomics"},{"name":"Department of Veterinary Integrative Bioscience"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,8,15]]},"reference":[{"key":"2026012806182102000_R1","first-page":"217","article-title":"Embryo implantation","volume-title":"Dev. 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