{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:59:24Z","timestamp":1791255564208,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-17A is originally identified as a proinflammatory cytokine that induces neutrophils. Although IL-17A production by CD4+ Th17 T cells is well documented, it is not clear whether IL-17A is produced and participates in the innate immune response against infections. In the present report, we demonstrate that IL-17A is expressed in the liver of mice infected with Listeria monocytogenes from an early stage of infection. IL-17A is important in protective immunity at an early stage of listerial infection in the liver because IL-17A-deficient mice showed aggravation of the protective response. The major IL-17A-producing cells at the early stage were TCR \u03b3\u03b4 T cells expressing TCR V\u03b34 or V\u03b36. Interestingly, TCR \u03b3\u03b4 T cells expressing both IFN-\u03b3 and IL-17A were hardly detected, indicating that the IL-17A-producing TCR \u03b3\u03b4 T cells are distinct from IFN-\u03b3-producing \u03b3\u03b4 T cells, similar to the distinction between Th17 and Th1 in CD4+ T cells. All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR \u03b3\u03b4 T cells, which is important in innate immunity in the liver.<\/jats:p>","DOI":"10.4049\/jimmunol.181.5.3456","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:32:15Z","timestamp":1397849535000},"page":"3456-3463","source":"Crossref","is-referenced-by-count":316,"title":["IL-17A Produced by \u03b3\u03b4 T Cells Plays a Critical Role in Innate Immunity against\n                    <i>Listeria monocytogenes<\/i>\n                    Infection in the Liver"],"prefix":"10.1093","volume":"181","author":[{"given":"Satoru","family":"Hamada","sequence":"first","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Division of Child Health and Welfare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Umemura","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Division of Host Defense and Vaccinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeru","family":"Shiono","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Division of Host Defense and Vaccinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensho","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus , Okinawa,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Yahagi","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Division of Host Defense and Vaccinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Dilara","family":"Begum","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Division of Host Defense and Vaccinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotetsu","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Division of Digestive and General Surgery, Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Group"},{"name":"Division of Host Defense and Vaccinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisami","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Immunobiology Group, Center of Molecular Biosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Microbiology and Immunology, Department of Medical Technology, School of Health Sciences, Faculty of Medicine and Infection Control Center, Tohoku University , Miyagi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Roark","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi K","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Keio University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Nakae","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institution of Medical Science, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institution of Medical Science, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ohta","sequence":"additional","affiliation":[{"name":"Division of Child Health and 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