{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:16:10Z","timestamp":1791141370979,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The mechanisms underlying the frequent association between chronic lymphocytic leukemia (CLL) and autoimmune hemolytic anemia are currently unclear. The erythrocyte protein band 3 (B3) is one of the most frequently targeted Ags in autoimmune hemolytic anemia. In this study, we show that CLL cells specifically recognize B3 through a still unidentified receptor. B3 interaction with CLL cells involves the recognition of its N-terminal domain and leads to its internalization. Interestingly, when binding of erythrocyte-derived vesicles as found physiologically in blood was assessed, we observed that CLL cells could only interact with inside-out vesicles, being this interaction strongly dependent on the recognition of the N-terminal portion of B3. We then examined T cell responses to B3 using circulating CLL cells as APCs. Resting B3-pulsed CLL cells were unable to induce T cell proliferation. However, when deficient costimulation was overcome by CD40 engagement, B3-pulsed CLL cells were capable of activating CD4+ T cells in a HLA-DR-dependent fashion. Therefore, our work shows that CLL cells can specifically bind, capture, and present B3 to T cells when in an activated state, an ability that could allow the neoplastic clone to trigger the autoaggressive process against erythrocytes.<\/jats:p>","DOI":"10.4049\/jimmunol.181.5.3674","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:32:15Z","timestamp":1397849535000},"page":"3674-3683","source":"Crossref","is-referenced-by-count":27,"title":["Chronic Lymphocytic Leukemia Cells Bind and Present the Erythrocyte Protein Band 3: Possible Role as Initiators of Autoimmune Hemolytic Anemia"],"prefix":"10.1093","volume":"181","author":[{"given":"Jerem\u00edas","family":"Galletti","sequence":"first","affiliation":[{"name":"Department of Immunology, Institute for Hematologic Research, National Academy of Medicine , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Ca\u00f1ones","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Hematologic Research, National Academy of Medicine , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Morande","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Hematologic Research, National Academy of Medicine , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Borge","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Hematologic Research, National Academy of Medicine , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Oppezzo","sequence":"additional","affiliation":[{"name":"Protein Production Unit, Institut Pasteur , Montevideo,","place":["Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Geffner","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Hematologic Research, National Academy of Medicine , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo","family":"Bezares","sequence":"additional","affiliation":[{"name":"Hospital Dr. T. Alvarez , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Gamberale","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Hematologic Research, National Academy of Medicine , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute for Hematologic Research, National Academy of Medicine , Buenos Aires,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"2026012806260769600_R1","first-page":"399","article-title":"B-cell chronic lymphocytic leukemia: a bird of a different feather","volume-title":"J. Clin. 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