{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:34:38Z","timestamp":1790937278319,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Splenectomized patients are susceptible to bloodstream infections with encapsulated bacteria, potentially due to loss of blood filtering but also defective production of anticarbohydrate Ab. Recent studies propose that a lack of Ab is related to reduced numbers of IgM+ CD27+ memory B cells found after splenectomy. To test this, we analyzed CD27+ memory B cell subsets, IgG, and IgM pneumococcal Ab responses in 26 vaccinated splenectomized subjects in comparison to memory B cell subsets and Ab responses in healthy controls. As shown previously, the splenectomized autoimmune subjects had fewer total, isotype switched, and IgM+ CD27+ memory B cells as compared with controls, but there was no difference in memory B cells subsets between controls and splenectomized subjects with spherocytosis. There was no difference between the geometric mean IgG Ab response between normal controls and splenectomized subjects (p = 0.51; p = 0.81). Control subjects produced more IgM Ab than splenectomized autoimmune subjects (p = 0.01) but the same levels as subjects with spherocytosis (p = 0.15.) There was no correlation between memory B cell subsets and IgG or IgM Ab responses for controls or splenectomized subjects. These data suggest that splenectomy alone may not be the sole reason for loss of memory B cells and reduced IgM antipneumococcal Ab. Because subjects with autoimmunity had splenectomy at a significantly older age than participants with spherocytosis, these data suggest that an age-related loss of extra splenic sites necessary for the maintenance or function of memory B cells may lead to impaired immunity in these subjects.<\/jats:p>","DOI":"10.4049\/jimmunol.181.5.3684","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:32:15Z","timestamp":1397849535000},"page":"3684-3689","source":"Crossref","is-referenced-by-count":63,"title":["Memory B Cells and Pneumococcal Antibody After Splenectomy"],"prefix":"10.1093","volume":"181","author":[{"given":"Heather","family":"Wasserstrom","sequence":"first","affiliation":[{"name":"Departments of Medicine, Pediatrics and the Immunology Institute, Mount Sinai Medical Center , New York City, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bussel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Weill Medical College, Cornell University , New York City, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lony C-L","family":"Lim","sequence":"additional","affiliation":[{"name":"Immunology Division, Specialty Laboratories , Valencia, CA 91355"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham-Rundles","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics and the Immunology Institute, Mount Sinai Medical Center , New York City, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"2026012806255120100_R1","first-page":"223","article-title":"Overwhelming postplenectomy infection","volume-title":"Surg. 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