{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:29:25Z","timestamp":1791268165629,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Egr-1 (early growth response gene-1) is an immediate early gene encoding a zinc finger motif-containing transcription factor. Upon cross-linking of BCR, mature B cells undergo proliferation with an increase in Egr-1 message. Immature B lymphoma cells that express Egr-1 message and protein constitutively are growth inhibited when Egr-1 is down-regulated by negative signals from BCR or by antisense oligonucleotides. To test the hypothesis that Egr-1 is important for B cell development, we examined B cells from primary and secondary lymphoid organs in Egr-1\u2212\/\u2212 mice. Marginal zone B cell development was arrested in these mice, whereas the B cells in all other compartments were increased. To test the hypothesis that Egr-1 function may be partially compensated by other Egr family members, we developed transgenic mice expressing a dominant negative form of Egr-1, which lacks the trans activation domain but retains the DNA-binding domain, in a B cell-specific manner. There was a decrease in B lymphopoiesis in the bone marrow accompanied by a reduction in splenic immature and mature B cells as well as marginal zone B cells in the transgenic mice. Moreover, transgenic mice respond poorly to BCR cross-linking in vitro and T-independent and T-dependent Ags in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.181.7.4590","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:07:10Z","timestamp":1397848030000},"page":"4590-4602","source":"Crossref","is-referenced-by-count":67,"title":["Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response"],"prefix":"10.1093","volume":"181","author":[{"given":"Murali","family":"Gururajan","sequence":"first","affiliation":[{"name":"Microbiology, Immunology"},{"name":"Graduate Center for Toxicology"},{"name":"Molecular Genetics, Sanders Brown Center on Aging"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Simmons","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology"},{"name":"Molecular Genetics, Sanders Brown Center on Aging"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trivikram","family":"Dasu","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology"},{"name":"Molecular Genetics, Sanders Brown Center on Aging"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett T","family":"Spear","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology"},{"name":"Graduate Center for Toxicology"},{"name":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Calulot","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell A","family":"Robertson","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology"},{"name":"Molecular Genetics, Sanders Brown Center on Aging"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Wiest","sequence":"additional","affiliation":[{"name":"Basic Science Division, Fox Chase Cancer Center , Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Monroe","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbarao","family":"Bondada","sequence":"additional","affiliation":[{"name":"Microbiology, Immunology"},{"name":"Graduate Center for Toxicology"},{"name":"Molecular Genetics, Sanders Brown Center on Aging"},{"name":"Markey Cancer Center, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"2026012807120243800_R1","first-page":"159","article-title":"The role of early growth response gene 1 (egr-1) in regulation of the immune response","volume-title":"J. 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