{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:50:18Z","timestamp":1792457418244,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The secreted goblet cell-derived protein resistin-like molecule \u03b2 (RELM\u03b2) has been implicated in divergent functions, including a direct effector function against parasitic helminths and a pathogenic function in promoting inflammation in models of colitis and ileitis. However, whether RELM\u03b2 influences CD4+ T cell responses in the intestine is unknown. Using a natural model of intestinal inflammation induced by chronic infection with gastrointestinal helminth Trichuris muris, we identify dual functions for RELM\u03b2 in augmenting CD4+ Th1 cell responses and promoting infection-induced intestinal inflammation. Following exposure to low-dose Trichuris, wild-type C57BL\/6 mice exhibit persistent infection associated with robust IFN-\u03b3 production and intestinal inflammation. In contrast, infected RELM\u03b2\u2212\/\u2212 mice exhibited a significantly reduced expression of parasite-specific CD4+ T cell-derived IFN-\u03b3 and TNF-\u03b1 and failed to develop Trichuris-induced intestinal inflammation. In in vitro T cell differentiation assays, recombinant RELM\u03b2 activated macrophages to express MHC class II and secrete IL-12\/23p40 and enhanced their ability to mediate Ag-specific IFN-\u03b3 expression in CD4+ T cells. Taken together, these data suggest that goblet cell-macrophage cross-talk, mediated in part by RELM\u03b2, can promote adaptive CD4+ T cell responses and chronic inflammation following intestinal helminth infection.<\/jats:p>","DOI":"10.4049\/jimmunol.181.7.4709","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:07:10Z","timestamp":1397862430000},"page":"4709-4715","source":"Crossref","is-referenced-by-count":94,"title":["Goblet Cell-Derived Resistin-Like Molecule \u03b2 Augments CD4+ T Cell Production of IFN-\u03b3 and Infection-Induced Intestinal Inflammation"],"prefix":"10.1093","volume":"181","author":[{"given":"Meera G","family":"Nair","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J","family":"Guild","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Zaph","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D","family":"Yancopoulos","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY 10591"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY 10591"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Murphy","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY 10591"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Stevens","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY 10591"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Karow","sequence":"additional","affiliation":[{"name":"Amgen , Thousand Oaks, CA 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Artis","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"2025032700303677900_R1","first-page":"331","article-title":"Anatomical basis of tolerance and immunity to intestinal antigens","volume-title":"Nat. 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