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Clinical observations uncovered the importance of autoimmune memory in vitiligo because cessation of treatment frequently led to relapse of disease at the site of previous lesions. A subset of memory T cells known as CD8+ resident memory T cells (TRM) are long-lived, nonmigratory memory cells that persist in most nonlymphoid tissues, including the skin. Recent reports describe the presence of CD8+ TRM in lesional vitiligo patient skin and suggest their role as active players in disease maintenance. In this review, we will discuss the role of skin CD8+ TRM in maintaining disease in vitiligo and the opportunity to target this population to induce a long-lasting reversal of disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1900027","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T21:25:34Z","timestamp":1560806734000},"page":"11-19","source":"Crossref","is-referenced-by-count":162,"title":["The Role of Memory CD8+ T Cells in Vitiligo"],"prefix":"10.1093","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-9848","authenticated-orcid":false,"given":"Rebecca L","family":"Riding","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"2025030418132914900_r1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1056\/NEJMcp0804388","article-title":"Clinical practice. 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