{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:07:08Z","timestamp":1779174428567,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignancy increases sepsis incidence 10-fold and elevates sepsis-associated mortality. Advances in treatment have improved survival of cancer patients shortly after sepsis, but there is a paucity of information on how sepsis impacts cancer growth, development, and prognosis. To test this, cecal ligation and puncture surgery was performed on B16 melanoma-bearing mice to show that sepsis has detrimental effects in hosts with advanced tumors, leading to increased mortality. Surprisingly, mice experiencing cecal ligation and puncture\u2013induced sepsis earlier during tumor development exhibited CD8 T cell\u2013dependent attenuation of tumor growth. Sepsis-resistant CD8 tumor-infiltrating T cells showed increased in vivo activation, effector IFN-\u03b3 cytokine production, proliferation, and expression of activation\/inhibitory PD-1\/LAG-3 receptors because of a sepsis-induced liberation of tumor Ags. Sepsis-reinvigorated CD8 tumor-infiltrating T cells were also amenable to (anti\u2013PD-L1\/LAG-3) checkpoint blockade therapy, further prolonging cancer-associated survival in sepsis survivors. Thus, sepsis has the capacity to improve tumor-specific CD8 T cell responses, leading to better cancer prognosis and increased survival.<\/jats:p>","DOI":"10.4049\/jimmunol.1900076","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T20:14:06Z","timestamp":1554927246000},"page":"2843-2848","source":"Crossref","is-referenced-by-count":26,"title":["Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-8797","authenticated-orcid":false,"given":"Derek B","family":"Danahy","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-3961","authenticated-orcid":false,"given":"Isaac J","family":"Jensen","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7205-9859","authenticated-orcid":false,"given":"Thomas S","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-2439","authenticated-orcid":false,"given":"Vladimir P","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Microbiology and Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"2025030417562043300_r1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014","volume":"318","author":"Rhee","year":"2017","journal-title":"JAMA"},{"key":"2025030417562043300_r2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1378\/chest.129.6.1432","article-title":"The epidemiology of sepsis in patients with malignancy","volume":"129","author":"Danai","year":"2006","journal-title":"Chest"},{"key":"2025030417562043300_r3","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1186\/cc2893","article-title":"Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care","volume":"8","author":"Williams","year":"2004","journal-title":"Crit. 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