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However, the regulatory mechanism of HDM-induced CD11b+ DC activation remains incompletely understood. In this study, we demonstrate that mice deficient in an inhibitory immunoreceptor, Allergin-1, showed exacerbated HDM-induced airway eosinophilia and serum IgE elevation. By using bone marrow\u2013chimeric mice that were sensitized with adoptively transferred HDM-stimulated wild-type or Allergin-1\u2013deficient CD11b+ bone marrow\u2013derived cultured DCs (BMDCs), followed by challenge with HDM, we show that Allergin-1 on the BMDCs suppressed HDM-induced allergic airway inflammation. We also show that Allergin-1 suppressed HDM-induced PGE2 production from CD11b+ BMDCs by inhibiting Syk tyrosine kinase activation through recruitment of SHP-1, subsequently leading to negative regulation of Th2 responses. These results suggest that Allergin-1 plays an important role in regulation of HDM-induced allergic airway inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1900180","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T21:54:19Z","timestamp":1578088459000},"page":"753-762","source":"Crossref","is-referenced-by-count":8,"title":["Allergin-1 Immunoreceptor Suppresses House Dust Mite\u2013Induced Allergic Airway Inflammation"],"prefix":"10.1093","volume":"204","author":[{"given":"Haruka","family":"Miki","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki 305-8575 ,","place":["Japan"]},{"name":"Department of Internal Medicine, Faculty of Medicine, Tsukuba Advanced Research Alliance, R&D Center for Innovative Drug Discovery , Tsukuba, Ibaraki 305-8575 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