{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:23:15Z","timestamp":1777494195470,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infection with Listeria monocytogenes is acquired through ingestion of contaminated foods and may lead to systemic infection and possible death, with an overall 20% mortality rate. Our previous work using C5aR1\u2212\/\u2212 mice and C3aR\u2212\/\u2212 mice demonstrated that C5aR1 and C3aR both play powerful anti-inflammatory and prosurvival roles during systemic infection with L. monocytogenes. In our current study, we have examined the role of the third anaphylatoxin receptor, C5aR2, in the host immune response to systemic L. monocytogenes infection. C5aR2\u2212\/\u2212 mice had significantly lower bacterial burdens in the spleens and livers on both day 1 and 3 postinfection compared with C5aR2+\/+ mice. The decreased bacterial burdens in the C5aR2\u2212\/\u2212 mice correlated with less liver damage and with improved survival of CD4+ and CD8+ T cells in the spleen on day 3 postinfection compared with C5aR2+\/+ mice. C5aR2\u2212\/\u2212 mice also produced significantly less G-CSF, IL-6, and MCP-1 in the serum, spleen, and liver on day 1 postinfection compared with C5aR2+\/+ mice. C5aR2\u2212\/\u2212 and C5aR2+\/+ mice produced similar amounts of IFN-\u03b3 in their spleens on day 1 postinfection. Purified naive splenocytes from C5aR2\u2212\/\u2212 mice produced significantly more IFN-\u03b3 and IL-12p70 during in vitro infection with L. monocytogenes compared with splenocytes from C5aR2+\/+ mice in an NF-\u03baB\u2013dependent manner. Induction of IL-12 and IFN-\u03b3 early during infection with L. monocytogenes is protective to the host, and we believe this innate increased ability to produce more IL-12 and IFN-\u03b3 provided early protection to the C5aR2\u2212\/\u2212 mice.<\/jats:p>","DOI":"10.4049\/jimmunol.1900314","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T18:25:16Z","timestamp":1570645516000},"page":"2701-2711","source":"Crossref","is-referenced-by-count":11,"title":["The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with <i>Listeria monocytogenes<\/i>"],"prefix":"10.1093","volume":"203","author":[{"given":"Stacey L","family":"Mueller-Ortiz","sequence":"first","affiliation":[{"name":"Brown Foundation Institute of Molecular Medicine, Research Center for Immunology and Autoimmune Diseases, University of Texas Health Science Center at Houston , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Shivshankar","sequence":"additional","affiliation":[{"name":"Brown Foundation Institute of Molecular Medicine, Research Center for Immunology and Autoimmune Diseases, University of Texas Health Science Center at Houston , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-5096","authenticated-orcid":false,"given":"Rick A","family":"Wetsel","sequence":"additional","affiliation":[{"name":"Brown Foundation Institute of Molecular Medicine, Research Center for Immunology and Autoimmune Diseases, University of Texas Health Science Center at Houston , Houston, TX 77030"},{"name":"Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"2025030417544110500_r1","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1086\/338465","article-title":"Listeria monocytogenes: clinical and experimental update","volume":"185","author":"Wing","year":"2002","journal-title":"J. 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