{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:37:25Z","timestamp":1791383845328,"version":"4.3.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Council of Technological and Scientific Development","award":["441665\/2014-4"],"award-info":[{"award-number":["441665\/2014-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell diseases characterized by dysplasia of one or more hematologic lineages and a high risk of developing into acute myeloid leukemia. MDS patients have recurrent bacterial infections and abnormal expression of CD56 by monocytes. We investigated MDS patients\u2019 bone marrow CD56+\/CD56\u2212 monocytes and their in vitro\u2013derived dendritic cell populations in comparison with cells obtained from disease-free subjects. We found that monocytes from MDS patients, irrespective of CD56 expression, have reduced phagocytosis activity and low expression of genes involved in triggering immune responses, regulation of immune and inflammatory response signaling pathways, and in the response to LPS. Dendritic cells derived in vitro from MDS monocytes failed to develop dendritic projections and had reduced expression of HLA-DR and CD86, suggesting that Ag processing and T cell activation capabilities are impaired. In conclusion, we identified, in both CD56+ and CD56\u2212 monocytes from MDS patients, several abnormalities that may be related to the increased susceptibility to infections observed in these patients.<\/jats:p>","DOI":"10.4049\/jimmunol.1900328","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:24:52Z","timestamp":1584404692000},"page":"2098-2109","source":"Crossref","is-referenced-by-count":11,"title":["Bone Marrow Monocytes and Derived Dendritic Cells from Myelodysplastic Patients Have Functional Abnormalities Associated with Defective Response to Bacterial Infection"],"prefix":"10.1093","volume":"204","author":[{"given":"Laiz C","family":"Bento","sequence":"first","affiliation":[{"name":"Clinical Pathology Laboratory, Hospital Israelita Albert Einstein , S\u00e3o Paulo 05652 000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nydia S","family":"Bacal","sequence":"additional","affiliation":[{"name":"Clinical Pathology Laboratory, Hospital Israelita Albert Einstein , S\u00e3o Paulo 05652 000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda A","family":"Rocha","sequence":"additional","affiliation":[{"name":"Experimental Research Laboratory, Hospital Israelita Albert Einstein , S\u00e3o Paulo 05652 000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-9343","authenticated-orcid":false,"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"Experimental Research Laboratory, Hospital Israelita Albert Einstein , S\u00e3o Paulo 05652 000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3890-0827","authenticated-orcid":false,"given":"Luciana C","family":"Marti","sequence":"additional","affiliation":[{"name":"Experimental Research Laboratory, Hospital Israelita Albert Einstein , S\u00e3o Paulo 05652 000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"2025030417511463100_r1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World health organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"2025030417511463100_r2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fonc.2017.00270","article-title":"The use of flow cytometry in myelodysplastic syndromes: a review","volume":"7","author":"Bento","year":"2017","journal-title":"Front. 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