{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:53:48Z","timestamp":1768200828784,"version":"3.49.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Singleton-Merten syndrome (SMS) is a type I interferonopathy characterized by dental dysplasia, aortic calcification, skeletal abnormalities, glaucoma, and psoriasis. A missense mutation in IFIH1 encoding a cytoplasmic viral RNA sensor MDA5 has recently been identified in the SMS patients as well as in patients with a monogenic form of lupus. We previously reported that Ifih1gs\/+ mice express a constitutively active MDA5 and spontaneously develop lupus-like nephritis. In this study, we demonstrate that the Ifih1gs\/+ mice also exhibit SMS-like bone abnormalities, including decreased bone mineral density and thin cortical bone. Histological analysis revealed a low number of osteoclasts, low bone formation rate, and abnormal development of growth plate cartilages in Ifih1gs\/+ mice. These abnormalities were not observed in Ifih1gs\/+\u30fbMavs\u2212\/\u2212 and Ifih1gs\/+\u30fbIfnar1\u2212\/\u2212 mice, indicating the critical role of type I IFNs induced by MDA5\/MAVS-dependent signaling in the bone pathogenesis of Ifih1gs\/+ mice, affecting bone turnover. Taken together, our findings suggest the inhibition of type I IFN signaling as a possible effective therapeutic strategy for bone disorders in SMS patients.<\/jats:p>","DOI":"10.4049\/jimmunol.1900354","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T19:05:19Z","timestamp":1564599919000},"page":"1356-1368","source":"Crossref","is-referenced-by-count":25,"title":["Singleton-Merten Syndrome\u2013like Skeletal Abnormalities in Mice with Constitutively Activated MDA5"],"prefix":"10.1093","volume":"203","author":[{"given":"Nobumasa","family":"Soda","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute for Frontier Life and Medical Science, Kyoto University , Kyoto, 606-8507 \u00a0","place":["Japan"]},{"name":"Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University , Kyoto, 606-8501 \u00a0","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-6480","authenticated-orcid":false,"given":"Nobuhiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Showa University , Tokyo, 142-8555 \u00a0","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kato","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute for Frontier Life and Medical Science, Kyoto University , Kyoto, 606-8507 \u00a0","place":["Japan"]},{"name":"Institute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn , Bonn, 53127 \u00a0","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-3975","authenticated-orcid":false,"given":"Masamichi","family":"Takami","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Showa University , Tokyo, 142-8555 \u00a0","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-0535","authenticated-orcid":false,"given":"Takashi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute for Frontier Life and Medical Science, Kyoto University , Kyoto, 606-8507 \u00a0","place":["Japan"]},{"name":"Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University , Kyoto, 606-8501 \u00a0","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,1]]},"reference":[{"key":"2025030417541571500_r1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF00972817","article-title":"An unusual syndrome of widened medullary cavities of the metacarpals and phalanges, aortic calcification and abnormal dentition","volume":"1","author":"Singleton","year":"1973","journal-title":"Pediatr. 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A."},{"key":"2025030417541571500_r5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ajhg.2014.12.014","article-title":"A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome","volume":"96","author":"Rutsch","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"2025030417541571500_r6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ajhg.2014.11.019","article-title":"Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome","volume":"96","author":"Jang","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"2025030417541571500_r7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. 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N. Y. Acad. Sci."},{"key":"2025030417541571500_r20","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1128\/MCB.24.15.6719-6727.2004","article-title":"Gene-targeted mice lacking the Trex1 (DNase III) 3\u2032--&gt;5\u2032 DNA exonuclease develop inflammatory myocarditis","volume":"24","author":"Morita","year":"2004","journal-title":"Mol. Cell. 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Clin. Invest."},{"key":"2025030417541571500_r35","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1101\/gad.1119303","article-title":"Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation","volume":"17","author":"Kim","year":"2003","journal-title":"Genes Dev."},{"key":"2025030417541571500_r36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(04)00344-7","article-title":"ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"2025030417541571500_r37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature11000","article-title":"Osteoprotection by semaphorin 3A","volume":"485","author":"Hayashi","year":"2012","journal-title":"Nature"},{"key":"2025030417541571500_r38","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/nm.2489","article-title":"Suppression of bone formation by osteoclastic expression of semaphorin 4D","volume":"17","author":"Negishi-Koga","year":"2011","journal-title":"Nat. Med."},{"key":"2025030417541571500_r39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1359\/JBMR.051007","article-title":"Identification of multiple osteoclast precursor populations in murine bone marrow","volume":"21","author":"Jacquin","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"2025030417541571500_r40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/edrv.20.3.0367","article-title":"Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families","volume":"20","author":"Suda","year":"1999","journal-title":"Endocr. Rev."},{"key":"2025030417541571500_r41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"2025030417541571500_r42","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4049\/jimmunol.169.3.1516","article-title":"Stimulation by toll-like receptors inhibits osteoclast differentiation","volume":"169","author":"Takami","year":"2002","journal-title":"J. Immunol."},{"key":"2025030417541571500_r43","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/416744a","article-title":"RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta","volume":"416","author":"Takayanagi","year":"2002","journal-title":"Nature"},{"key":"2025030417541571500_r44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030417541571500_r45","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1084\/jem.182.5.1461","article-title":"Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors","volume":"182","author":"Udagawa","year":"1995","journal-title":"J. Exp. Med."},{"key":"2025030417541571500_r46","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20050978","article-title":"Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis","volume":"202","author":"Kim","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025030417541571500_r47","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.4049\/jimmunol.0803007","article-title":"The mechanism of osteoclast differentiation induced by IL-1","volume":"183","author":"Kim","year":"2009","journal-title":"J. Immunol."},{"key":"2025030417541571500_r48","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1210\/endo.141.11.7739","article-title":"Inhibition of osteoblast differentiation by tumor necrosis factor-alpha","volume":"141","author":"Gilbert","year":"2000","journal-title":"Endocrinology"},{"key":"2025030417541571500_r49","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1074\/jbc.M106339200","article-title":"Expression of the osteoblast differentiation factor RUNX2 (Cbfa1\/AML3\/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha","volume":"277","author":"Gilbert","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025030417541571500_r50","doi-asserted-by":"crossref","first-page":"E1011","DOI":"10.1152\/ajpendo.00534.2004","article-title":"The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis","volume":"288","author":"Gilbert","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2025030417541571500_r51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/jir.2016.0095","article-title":"RIG-I-like receptors and type I interferonopathies","volume":"37","author":"Kato","year":"2017","journal-title":"J. Interferon Cytokine Res."},{"key":"2025030417541571500_r52","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev-med-050715-104506","article-title":"The type I interferonopathies","volume":"68","author":"Lee-Kirsch","year":"2017","journal-title":"Annu. Rev. Med."},{"issue":"Database issue","key":"2025030417541571500_r53","doi-asserted-by":"crossref","first-page":"D852","DOI":"10.1093\/nar\/gkn732","article-title":"INTERFEROME: the database of interferon regulated genes","volume":"37","author":"Samarajiwa","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2025030417541571500_r54","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int."},{"key":"2025030417541571500_r55","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1074\/jbc.M512624200","article-title":"Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression","volume":"281","author":"Yao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2025030417541571500_r56","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jbmr.5650070502","article-title":"Interleukin-6: an osteotropic factor?","volume":"7","author":"Roodman","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"2025030417541571500_r57","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0736-0266(00)00078-4","article-title":"Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha","volume":"19","author":"Aizawa","year":"2001","journal-title":"J. Orthop. Res."},{"key":"2025030417541571500_r58","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1172\/JCI77716","article-title":"MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation","volume":"125","author":"Li","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2025030417541571500_r59","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.130","article-title":"Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow","volume":"4","author":"Liao","year":"2013","journal-title":"Cell Death Dis."},{"key":"2025030417541571500_r60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020360","article-title":"Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment","volume":"19","author":"Hu","year":"2018","journal-title":"Int. J. Mol. 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