{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:16:45Z","timestamp":1793726205687,"version":"4.6.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Proinflammatory macrophages and miR-155 are increased in patients with rheumatoid arthritis (RA). We studied membrane TNF (mTNF) expression on blood monocytes, polarization into macrophages, miR-155 expression, and the effect of anti-TNF on these biomarkers in RA patients. Sixty-seven RA patients and 109 controls (55 healthy, 54 with spondyloarthritis and connective tissue diseases) were studied. Monocytes were isolated and differentiated into macrophages with or without anti-TNF. mTNF expression was increased on monocytes from RA patients, but not from other inflammatory diseases, correlated with disease activity. Under human serum AB or M-CSF, only monocytes from RA had a defect of differentiation into M2-like macrophages and had a propensity for preferential maturation toward M1-like macrophages that contributed to synovial inflammation. This defect was correlated to mTNF expression and was partially reversed by monoclonal anti-TNF Abs but not by the TNF soluble receptor. miR-155 was increased in M2-macrophages except in adalimumab-treated patients. Transfection of healthy monocytes with miR-155 induced a decrease in M2-like markers, and transfection of RA monocytes with antagomir-155 allowed restoration of M2-like polarization. Defect in differentiation of monocytes into M2-like-macrophages linked to increased miR-155 and correlated with increased mTNF on monocytes could play a key role in RA pathogenesis. Monoclonal anti-TNF Abs but not the TNF soluble receptor partially restored this defect.<\/jats:p>","DOI":"10.4049\/jimmunol.1900386","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T20:39:02Z","timestamp":1567629542000},"page":"1766-1775","source":"Crossref","is-referenced-by-count":75,"title":["Monocyte\/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors"],"prefix":"10.1093","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-385X","authenticated-orcid":false,"given":"Audrey","family":"Paoletti","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Rohmer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bineta","family":"Ly","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Pascaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-3081","authenticated-orcid":false,"given":"Elodie","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaele","family":"Seror","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]},{"name":"Rheumatology Department, H\u00f4pitaux Universitaires Paris-Sud, Assistance Publique \u2013 H\u00f4pitaux de Paris , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Le Goff","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centre Hospitalier Universitaire de Nantes , 44000 Nantes, Pays de la Loire ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetane","family":"Nocturne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]},{"name":"Rheumatology Department, H\u00f4pitaux Universitaires Paris-Sud, Assistance Publique \u2013 H\u00f4pitaux de Paris , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-5417","authenticated-orcid":false,"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]},{"name":"Rheumatology Department, H\u00f4pitaux Universitaires Paris-Sud, Assistance Publique \u2013 H\u00f4pitaux de Paris , 94270 Le Kremlin Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"2025030417542835600_r1","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis","volume":"389","author":"McInnes","year":"2017","journal-title":"Lancet"},{"key":"2025030417542835600_r2","first-page":"620","article-title":"Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers","volume":"34","author":"Bresnihan","year":"2007","journal-title":"J. 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