{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:51:12Z","timestamp":1793904672735,"version":"4.8.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immune evasion strategies adopted by Leishmania donovani involve the exploitation of suppressor of cytokine signaling (SOCS) proteins that are well-known negative regulators of the JAK\/STAT pathway. However, the cellular mechanism underpinning the induction of SOCS isoforms and their role in breaching the multilevel regulatory circuit connecting the innate and adaptive arms of immunity are still ambiguous during experimental visceral leishmaniasis. Using bone marrow\u2013derived macrophages (BMM\u0444s) and CD4+ T cells, we observed that L. donovani preferentially upregulates SOCS1 and SOCS3 expression in macrophages and T cells, respectively, whereas the SOCS1 level remains consistently high in BMM\u0444s and SOCS3 expression is pronounced and long lasting in T cells. Consequently, this inhibits STAT1-mediated IL-12 induction in macrophages &amp; STAT4-mediated IFN-\u03b3 synthesis in T cells. Mechanistically, PI3K\/Akt\u2013mediated SRF activation promotes nuclear translocation and binding of Egr2 to SOCS1 promoter for its early induction in infected BMM\u0444s. Additionally, L. donovani activates IDO\/kynurenine\/AHR signaling in BMM\u0444s to maintain prolonged SOCS1 expression. Later, PGE2, secreted from infected BMM\u0444s induces cAMP\u2013PKA pathway by binding to the EP2\/EP4 receptor of CD4+ T cells, leading to SP1, CREB, and GATA1 activation and SOCS3 expression. Small interfering RNA\u2013mediated silencing of SOCS1 and SOCS3 in macrophage and T cells, respectively, restored IL-12 and IFN-\u03b3 cytokine levels and BMM\u0444\u2013T cell interaction. Vivo morpholino\u2013mediated silencing of SOCS1 and SOCS3 resulted in protective cytokine responses, thereby reducing organ parasite burden significantly in L. donovani\u2013infected BALB\/c mice. Collectively, our results imply that L. donovani orchestrates different SOCS isoforms to impair macrophage\u2013T cell cross-talk and preserve its own niche.<\/jats:p>","DOI":"10.4049\/jimmunol.1900412","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T16:35:14Z","timestamp":1577464514000},"page":"596-610","source":"Crossref","is-referenced-by-count":29,"title":["Differential Induction of SOCS Isoforms by\n                    <i>Leishmania donovani<\/i>\n                    Impairs Macrophage\u2013T Cell Cross-Talk and Host Defense"],"prefix":"10.1093","volume":"204","author":[{"given":"Pragya","family":"Chandrakar","sequence":"first","affiliation":[{"name":"Division of Molecular Parasitology and Immunology, Council of Scientific and Industrial Research-Central Drug Research Institute , Lucknow 226031 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research , Ghaziabad, Uttar Pradesh 201002 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Parmar","sequence":"additional","affiliation":[{"name":"Division of Molecular Parasitology and Immunology, Council of Scientific and Industrial Research-Central Drug Research Institute , Lucknow 226031 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research , Ghaziabad, Uttar Pradesh 201002 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-5309","authenticated-orcid":false,"given":"Albert","family":"Descoteaux","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Scientifique-Centre Armand-Frappier Sant\u00e9 Biotechnologie , Laval, Quebec H7V 1B7 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9907-539X","authenticated-orcid":false,"given":"Susanta","family":"Kar","sequence":"additional","affiliation":[{"name":"Division of Molecular Parasitology and Immunology, Council of Scientific and Industrial Research-Central Drug Research Institute , Lucknow 226031 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research , Ghaziabad, Uttar Pradesh 201002 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,1]]},"reference":[{"key":"2025030417510512500_r1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1590\/0037-8682-0022-2012","article-title":"Involvement and interactions of different immune cells and their cytokines in human visceral leishmaniasis","volume":"46","author":"Bhattacharya","year":"2013","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"2025030417510512500_r2","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1242\/jcs.112.18.2993","article-title":"Leishmania species: models of intracellular parasitism","volume":"112","author":"Alexander","year":"1999","journal-title":"J. Cell Sci."},{"key":"2025030417510512500_r3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.iy.13.040195.001055","article-title":"The regulation of immunity to Leishmania major","volume":"13","author":"Reiner","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417510512500_r4","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/intimm\/dxh313","article-title":"Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice","volume":"17","author":"Rosas","year":"2005","journal-title":"Int. Immunol."},{"key":"2025030417510512500_r5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-695X.2007.00311.x","article-title":"Immune response to leishmania: paradox rather than paradigm","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2025030417510512500_r6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.semcdb.2008.07.010","article-title":"SOCS regulation of the JAK\/STAT signalling pathway","volume":"19","author":"Croker","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"2025030417510512500_r7","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1161\/ATVBAHA.114.304144","article-title":"Suppressor of cytokine signaling 1-derived peptide inhibits Janus kinase\/signal transducers and activators of transcription pathway and improves inflammation and atherosclerosis in diabetic mice","volume":"34","author":"Recio","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025030417510512500_r8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1600-065X.2008.00659.x","article-title":"Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins","volume":"224","author":"Dimitriou","year":"2008","journal-title":"Immunol. Rev."},{"key":"2025030417510512500_r9","doi-asserted-by":"crossref","first-page":"R899","DOI":"10.1016\/S0960-9822(00)80079-2","article-title":"Inhibitors keep cytokines in check","volume":"9","author":"Kovanen","year":"1999","journal-title":"Curr. Biol."},{"key":"2025030417510512500_r10","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.4049\/jimmunol.163.5.2640","article-title":"Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma","volume":"163","author":"Stoiber","year":"1999","journal-title":"J. Immunol."},{"key":"2025030417510512500_r11","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.166.1.466","article-title":"Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3","volume":"166","author":"Stoiber","year":"2001","journal-title":"J. Immunol."},{"key":"2025030417510512500_r12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nri2093","article-title":"SOCS proteins, cytokine signalling and immune regulation","volume":"7","author":"Yoshimura","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417510512500_r13","doi-asserted-by":"crossref","first-page":"9964","DOI":"10.1073\/pnas.0603507103","article-title":"Nucleophosmin\/anaplastic lymphoma kinase (NPM\/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3","volume":"103","author":"Kasprzycka","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417510512500_r14","first-page":"1","article-title":"SOCS proteins in development and disease","volume":"2","author":"Trengove","year":"2013","journal-title":"Am. J. Clin. Exp. Immunol."},{"key":"2025030417510512500_r15","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.4049\/jimmunol.176.3.1840","article-title":"Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling","volume":"176","author":"Zimmermann","year":"2006","journal-title":"J. Immunol."},{"key":"2025030417510512500_r16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0928-8244(03)00231-1","article-title":"Mycobacterium bovis bacillus Calmette-Gu\u00e9rin infection promotes SOCS induction and inhibits IFN-gamma-stimulated JAK\/STAT signaling in J774 macrophages","volume":"39","author":"Imai","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2025030417510512500_r17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Th\u00e9ry","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417510512500_r18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-3024.2003.00616.x","article-title":"The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA","volume":"25","author":"Bullen","year":"2003","journal-title":"Parasite Immunol."},{"key":"2025030417510512500_r19","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.4049\/jimmunol.180.6.4040","article-title":"SOCS-1 protects against Chlamydia pneumoniae-induced lethal inflammation but hampers effective bacterial clearance","volume":"180","author":"Yang","year":"2008","journal-title":"J. Immunol."},{"key":"2025030417510512500_r20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S1097-2765(03)00490-8","article-title":"Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65\/RelA","volume":"12","author":"Ryo","year":"2003","journal-title":"Mol. Cell"},{"key":"2025030417510512500_r21","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/1521-4141(2000)30:8<2235::AID-IMMU2235>3.0.CO;2-9","article-title":"Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1\/2 during infection of naive macrophages","volume":"30","author":"Priv\u00e9","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"2025030417510512500_r22","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.1800062","article-title":"Leishmania donovani exploits tollip, a multitasking protein, to impair TLR\/IL-1R signaling for its survival in the host","volume":"201","author":"Parmar","year":"2018","journal-title":"J. Immunol."},{"key":"2025030417510512500_r23","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/ATVBAHA.110.207464","article-title":"Suppressors of cytokine signaling (SOCS) proteins and JAK\/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3","volume":"31","author":"Tamiya","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025030417510512500_r24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.immuni.2012.08.001","article-title":"The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells","volume":"37","author":"Li","year":"2012","journal-title":"Immunity"},{"key":"2025030417510512500_r25","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/IAI.00575-16","article-title":"The aryl hydrocarbon receptor modulates production of cytokines and reactive oxygen species and development of myocarditis during Trypanosoma cruzi infection","volume":"84","author":"Barroso","year":"2016","journal-title":"Infect. Immun."},{"key":"2025030417510512500_r26","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.4049\/jimmunol.1001426","article-title":"The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Kr\u00fcppel-like factor-4, and it is dysregulated in psoriatic keratinocytes","volume":"185","author":"Madonna","year":"2010","journal-title":"J. Immunol."},{"key":"2025030417510512500_r27","doi-asserted-by":"crossref","first-page":"e18335","DOI":"10.1371\/journal.pone.0018335","article-title":"Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells","volume":"6","author":"Wiley","year":"2011","journal-title":"PLoS One"},{"key":"2025030417510512500_r28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1742-2094-9-78","article-title":"Serum response factor modulates neuron survival during peripheral axon injury","volume":"9","author":"Stern","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"2025030417510512500_r29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1634\/stemcells.21-2-123","article-title":"Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling","volume":"21","author":"Mora-Garcia","year":"2003","journal-title":"Stem Cells"},{"key":"2025030417510512500_r30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1462-5822.2006.00769.x","article-title":"Leishmania promastigotes activate PI3K\/Akt signalling to confer host cell resistance to apoptosis","volume":"9","author":"Ruhland","year":"2007","journal-title":"Cell. Microbiol."},{"key":"2025030417510512500_r31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00018-017-2653-3","article-title":"Ammonium trichloro [1,2-ethanediolato-O,O\u2032]-tellurate cures experimental visceral leishmaniasis by redox modulation of Leishmania donovani trypanothione reductase and inhibiting host integrin linked PI3K\/Akt pathway","volume":"75","author":"Vishwakarma","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"2025030417510512500_r32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/CMR.18.2.293-305.2005","article-title":"Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view","volume":"18","author":"Olivier","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"2025030417510512500_r33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fcimb.2012.00072","article-title":"Impact of Leishmania metalloprotease GP63 on macrophage signaling","volume":"2","author":"Isnard","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2025030417510512500_r34","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1002\/eji.200324128","article-title":"MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and toll-like receptor 2 signaling","volume":"33","author":"de Veer","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2025030417510512500_r35","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1074\/jbc.M109072200","article-title":"Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence","volume":"277","author":"McGwire","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025030417510512500_r36","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.micinf.2010.07.010","article-title":"Influence of leishmanolysin-like molecules of Herpetomonas samuelpessoai on the interaction with macrophages","volume":"12","author":"Pereira","year":"2010","journal-title":"Microbes Infect."},{"key":"2025030417510512500_r37","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/IAI.00611-07","article-title":"gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB\/c mice infected with Leishmania donovani","volume":"76","author":"Bhowmick","year":"2008","journal-title":"Infect. Immun."},{"key":"2025030417510512500_r38","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.4049\/jimmunol.179.9.5966","article-title":"Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia","volume":"179","author":"Qin","year":"2007","journal-title":"J. Immunol."},{"key":"2025030417510512500_r39","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.2119\/molmed.2012.00277","article-title":"STAT1, STAT6 and adenosine 3\u2032,5\u2032-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis","volume":"18","author":"Li","year":"2012","journal-title":"Mol. Med."},{"key":"2025030417510512500_r40","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1210\/me.2006-0498","article-title":"Regulation of suppressor of cytokine signaling 3 (SOC3) by growth hormone in pro-B cells","volume":"21","author":"Barclay","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"2025030417510512500_r41","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1210\/me.2007-0030","article-title":"Characterization of the SOCS3 promoter response to prostaglandin E2 in T47D cells","volume":"21","author":"Barclay","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"2025030417510512500_r42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0008-8749(84)90181-3","article-title":"Arachidonic acid metabolism in murine leishmaniasis (Donovani): ex-vivo evidence for increased cyclooxygenase and 5-lipoxygenase activity in spleen cells","volume":"88","author":"Reiner","year":"1984","journal-title":"Cell. Immunol."},{"key":"2025030417510512500_r43","doi-asserted-by":"crossref","first-page":"556","DOI":"10.4049\/jimmunol.134.1.556","article-title":"Arachidonic acid metabolism by murine peritoneal macrophages infected with Leishmania donovani: in vitro evidence for parasite-induced alterations in cyclooxygenase and lipoxygenase pathways","volume":"134","author":"Reiner","year":"1985","journal-title":"J. Immunol."},{"key":"2025030417510512500_r44","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.4049\/jimmunol.1400399","article-title":"Prostaglandin E2 negatively regulates the production of inflammatory cytokines\/chemokines and IL-17 in visceral leishmaniasis","volume":"193","author":"Saha","year":"2014","journal-title":"J. Immunol."},{"key":"2025030417510512500_r45","first-page":"552","article-title":"Activation of PGE2\/EP2 and PGE2\/EP4 signaling pathways positively regulate the level of PD-1 in infiltrating CD8+ T cells in patients with lung cancer","volume":"15","author":"Wang","year":"2018","journal-title":"Oncol. Lett."},{"key":"2025030417510512500_r46","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jaci.2018.05.036","article-title":"T cell-intrinsic prostaglandin E2-EP2\/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation","volume":"143","author":"Lee","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025030417510512500_r47","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1128\/iai.62.3.1058-1063.1994","article-title":"Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis","volume":"62","author":"Miralles","year":"1994","journal-title":"Infect. Immun."},{"key":"2025030417510512500_r48","doi-asserted-by":"crossref","first-page":"e0004308","DOI":"10.1371\/journal.pntd.0004308","article-title":"Genetic manipulation of Leishmania donovani to explore the involvement of argininosuccinate synthase in oxidative stress management","volume":"10","author":"Sardar","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2025030417510512500_r49","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1128\/IAI.71.4.2095-2101.2003","article-title":"Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation","volume":"71","author":"Bertholet","year":"2003","journal-title":"Infect. Immun."},{"key":"2025030417510512500_r50","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1074\/jbc.M113.496323","article-title":"Leishmania donovani prevents oxidative burst-mediated apoptosis of host macrophages through selective induction of suppressors of cytokine signaling (SOCS) proteins","volume":"289","author":"Srivastav","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2025030417510512500_r51","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.3892\/mmr.2017.7384","article-title":"Downregulated SOCS1 expression activates the JAK1\/STAT1 pathway and promotes polarization of macrophages into M1 type","volume":"16","author":"Liang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"2025030417510512500_r52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fimmu.2014.00058","article-title":"SOCS3, a major regulator of infection and inflammation","volume":"5","author":"Carow","year":"2014","journal-title":"Front. Immunol."},{"key":"2025030417510512500_r53","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1074\/jbc.M408938200","article-title":"Early growth response-1 regulates lipopolysaccharide-induced suppressor of cytokine signaling-1 transcription","volume":"280","author":"Mostecki","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025030417510512500_r54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.imbio.2011.08.008","article-title":"Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii","volume":"217","author":"Stutz","year":"2012","journal-title":"Immunobiology"},{"key":"2025030417510512500_r55","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/eji.201243046","article-title":"Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity","volume":"43","author":"Miah","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"2025030417510512500_r56","first-page":"e23952","article-title":"Egr2 and Egr3 are the unique regulators for systemic autoimmunity","volume":"2","author":"Sumitomo","year":"2013","journal-title":"JAKSTAT"},{"key":"2025030417510512500_r57","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1128\/IAI.01733-14","article-title":"Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection","volume":"82","author":"Brant","year":"2014","journal-title":"Infect. Immun."},{"key":"2025030417510512500_r58","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1124\/mol.104.002915","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells","volume":"66","author":"Boverhof","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"2025030417510512500_r59","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.4049\/jimmunol.1801053","article-title":"Leishmania donovani induces autophagy in human blood-derived neutrophils","volume":"202","author":"Pitale","year":"2019","journal-title":"J. Immunol."},{"key":"2025030417510512500_r60","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1096\/fasebj.9.11.7649404","article-title":"Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases","volume":"9","author":"Goetzl","year":"1995","journal-title":"FASEB J."},{"key":"2025030417510512500_r61","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.4049\/jimmunol.136.5.1820","article-title":"Chronic infection due to Mycobacterium intracellulare in mice: association with macrophage release of prostaglandin E2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-gamma","volume":"136","author":"Edwards","year":"1986","journal-title":"J. Immunol."},{"key":"2025030417510512500_r62","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/icb.2011.75","article-title":"Prostaglandin E2 and T cells: friends or foes?","volume":"90","author":"Sreeramkumar","year":"2012","journal-title":"Immunol. Cell Biol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/204\/3\/596\/61359970\/ji1900412.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/204\/3\/596\/61359970\/ji1900412.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T13:17:12Z","timestamp":1741094232000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/204\/3\/596\/7943863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,1]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1900412","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2020,2,1]]}}}