{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:42Z","timestamp":1787030862969,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI054359"],"award-info":[{"award-number":["R01AI054359"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB000487"],"award-info":[{"award-number":["R01EB000487"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI127429"],"award-info":[{"award-number":["R01AI127429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The presence of tissue-resident memory T cells at barrier tissues is critical for long-lasting protective immune responses. Previous work has shown that tissue-resident memory T cells can be established by \u201cpulling\u201d virus-specific effector T cells from circulation to the genital mucosa via topical vaginal application of chemokines in mice. Once established, these cells protect hosts against genital herpes infection. We recently showed that vaginal application of aminoglycoside antibiotics induces robust activation of the IFN signaling pathway, including upregulation of chemokine expression within the tissue in mice. In this study, we show that a single topical application of neomycin, an inexpensive and vaginally nontoxic antibiotic, is sufficient to pull CD8 T cells to the vaginal mucosa and provide protection against genital herpes infection in mice.<\/jats:p>","DOI":"10.4049\/jimmunol.1900462","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T15:35:13Z","timestamp":1583163313000},"page":"1703-1707","source":"Crossref","is-referenced-by-count":24,"title":["Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in \u201cPrime and Pull\u201d Vaccine Strategy"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3672-3780","authenticated-orcid":false,"given":"Smita","family":"Gopinath","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute , Chevy Chase, MD 20815"},{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT 06519"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT 06519"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-9856","authenticated-orcid":false,"given":"Akiko","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute , Chevy Chase, MD 20815"},{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT 06519"},{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, CT 06519"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"2025030417511181000_r1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/imr.12087","article-title":"Tissue-resident memory T cells","volume":"255","author":"Shin","year":"2013","journal-title":"Immunol. 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