{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:31:24Z","timestamp":1782801084422,"version":"3.54.5"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The MHC class I Ag presentation pathway in melanoma cells has a well-established role in immune-mediated destruction of tumors. However, the clinical significance of the MHC class II Ag presentation pathway in melanoma cells is less clear. In Ag-presenting cells, IFN-\u03b3\u2013inducible lysosomal thiol reductase (GILT) is critical for MHC class II\u2013restricted presentation of multiple melanoma Ags. Although not expressed in benign melanocytes of nevi, GILT and MHC class II expression is induced in malignant melanocytes in a portion of melanoma specimens. Analysis of The Cancer Genome Atlas cutaneous melanoma data set showed that high GILT mRNA expression was associated with improved overall survival. Expression of IFN-\u03b3, TNF-\u03b1, and IL-1\u03b2 was positively associated with GILT expression in melanoma specimens. These cytokines were capable of inducing GILT expression in human melanoma cells in vitro. GILT protein expression in melanocytes was induced in halo nevi, which are nevi undergoing immune-mediated regression, and is consistent with the association of GILT expression with improved survival in melanoma. To explore potential mechanisms of GILT\u2019s association with patient outcome, we investigated pathways related to GILT function and expression. In contrast to healthy skin specimens, in which the MHC class II pathway was nearly uniformly expressed and intact, there was substantial variation in the MHC class II pathway in the The Cancer Genome Atlas melanoma specimens. Both an active and intact MHC class II pathway were associated with improved overall survival in melanoma. These studies support a role for GILT and the MHC class II Ag presentation pathway in melanoma outcome.<\/jats:p>","DOI":"10.4049\/jimmunol.1900476","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T20:19:15Z","timestamp":1570479555000},"page":"2577-2587","source":"Crossref","is-referenced-by-count":34,"title":["High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma"],"prefix":"10.1093","volume":"203","author":[{"given":"Kenneth H","family":"Buetow","sequence":"first","affiliation":[{"name":"School of Life Sciences, Arizona State University , Tempe, AZ 85281"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia R","family":"Meador","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, University of Arizona College of Medicine , Phoenix, AZ 85004"},{"name":"University of Arizona Cancer Center, University of Arizona , Tucson, AZ 85724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-1405","authenticated-orcid":false,"given":"Hari","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, University of Arizona College of Medicine , Phoenix, AZ 85004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Kuang","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Arizona State University , Tempe, AZ 85281"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Brill","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Arizona State University , Tempe, AZ 85281"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-4835","authenticated-orcid":false,"given":"Haiyan","family":"Cui","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center, University of Arizona , Tucson, AZ 85724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise J","family":"Roe","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center, University of Arizona , Tucson, AZ 85724"},{"name":"Mel and Enid Zuckerman College of Public Health, University of Arizona , Tucson, AZ 85724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"DiCaudo","sequence":"additional","affiliation":[{"name":"Mayo Clinic , Scottsdale, AZ 85259"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-8033","authenticated-orcid":false,"given":"K Taraszka","family":"Hastings","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, University of Arizona College of Medicine , Phoenix, AZ 85004"},{"name":"University of Arizona Cancer Center, University of Arizona , Tucson, AZ 85724"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"2025030417544051200_r1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s00262-004-0517-9","article-title":"The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape","volume":"53","author":"Algarra","year":"2004","journal-title":"Cancer Immunol. Immunother."},{"key":"2025030417544051200_r2","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1158\/1078-0432.CCR-17-2483","article-title":"The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression","volume":"24","author":"Huang","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"2025030417544051200_r3","doi-asserted-by":"crossref","first-page":"eaar3342","DOI":"10.1126\/scitranslmed.aar3342","article-title":"MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma","volume":"10","author":"Rodig","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"2025030417544051200_r4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1399-0039.1996.tb02573.x","article-title":"Molecular and functional phenotypes of melanoma cells with abnormalities in HLA class I antigen expression","volume":"47","author":"Wang","year":"1996","journal-title":"Tissue Antigens"},{"key":"2025030417544051200_r5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJMoa1604958","article-title":"Mutations associated with acquired resistance to PD-1 blockade in melanoma","volume":"375","author":"Zaretsky","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2025030417544051200_r6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.20091918","article-title":"Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts","volume":"207","author":"Quezada","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025030417544051200_r7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/CMR.0000000000000230","article-title":"Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma","volume":"26","author":"Nguyen","year":"2016","journal-title":"Melanoma Res."},{"key":"2025030417544051200_r8","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2391::AID-CNCR14>3.0.CO;2-I","article-title":"Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?","volume":"85","author":"Ostmeier","year":"1999","journal-title":"Cancer"},{"key":"2025030417544051200_r9","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/jcp.41.10.1078","article-title":"DNA content and MHC class II antigen expression in malignant melanoma: clinical course","volume":"41","author":"Zaloudik","year":"1988","journal-title":"J. Clin. Pathol."},{"key":"2025030417544051200_r10","doi-asserted-by":"crossref","first-page":"7843","DOI":"10.4049\/jimmunol.181.11.7843","article-title":"MHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes","volume":"181","author":"Robila","year":"2008","journal-title":"J. Immunol."},{"key":"2025030417544051200_r11","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.4049\/jimmunol.1103269","article-title":"Heat shock protein 90-mediated peptide-selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4(+) T cells","volume":"188","author":"Tsuji","year":"2012","journal-title":"J. Immunol."},{"key":"2025030417544051200_r12","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1084\/jem.183.5.1965","article-title":"Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes","volume":"183","author":"Topalian","year":"1996","journal-title":"J. Exp. Med."},{"key":"2025030417544051200_r13","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1084\/jem.189.5.871","article-title":"Melanoma cells present a MAGE-3 epitope to CD4(+) cytotoxic T cells in association with histocompatibility leukocyte antigen DR11","volume":"189","author":"Manici","year":"1999","journal-title":"J. Exp. Med."},{"key":"2025030417544051200_r14","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.284.5418.1351","article-title":"Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen","volume":"284","author":"Wang","year":"1999","journal-title":"Science"},{"key":"2025030417544051200_r15","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.4049\/jimmunol.164.7.3535","article-title":"Identification of a MHC class II-restricted human gp100 epitope using DR4-IE transgenic mice","volume":"164","author":"Touloukian","year":"2000","journal-title":"J. Immunol."},{"key":"2025030417544051200_r16","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.4049\/jimmunol.165.11.6047","article-title":"Tumor-specific CD4+ T cells have a major \u201cpost-licensing\u201d role in CTL mediated anti-tumor immunity","volume":"165","author":"Marzo","year":"2000","journal-title":"J. Immunol."},{"key":"2025030417544051200_r17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.187.5.693","article-title":"Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors","volume":"187","author":"Ossendorp","year":"1998","journal-title":"J. Exp. Med."},{"key":"2025030417544051200_r18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1182\/blood-2002-11-3381","article-title":"Therapeutic effect of idiotype-specific CD4+ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodies","volume":"102","author":"Lundin","year":"2003","journal-title":"Blood"},{"key":"2025030417544051200_r19","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1158\/0008-5472.CAN-17-2426","article-title":"CD4+ T-cell-mediated rejection of MHC class II-positive tumor cells is dependent on antigen secretion and indirect presentation on host APCs","volume":"78","author":"Haabeth","year":"2018","journal-title":"Cancer Res."},{"key":"2025030417544051200_r20","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.1065500","article-title":"Defective antigen processing in GILT-free mice","volume":"294","author":"Maric","year":"2001","journal-title":"Science"},{"key":"2025030417544051200_r21","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.4049\/jimmunol.177.12.8569","article-title":"Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing","volume":"177","author":"Hastings","year":"2006","journal-title":"J. Immunol."},{"key":"2025030417544051200_r22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1084\/jem.20011853","article-title":"Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes","volume":"195","author":"Haque","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025030417544051200_r23","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.4049\/jimmunol.1000945","article-title":"GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1","volume":"185","author":"Rausch","year":"2010","journal-title":"J. Immunol."},{"key":"2025030417544051200_r24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fimmu.2013.00425","article-title":"Low GILT expression is associated with poor patient survival in diffuse large B-cell lymphoma","volume":"4","author":"Phipps-Yonas","year":"2013","journal-title":"Front. Immunol."},{"key":"2025030417544051200_r25","doi-asserted-by":"crossref","first-page":"e109449","DOI":"10.1371\/journal.pone.0109449","article-title":"Absence of gamma-interferon-inducible lysosomal thiol reductase (GILT) is associated with poor disease-free survival in breast cancer patients. [Published erratum appears in 2015 PLoS One 10: e0117653.]","volume":"9","author":"Xiang","year":"2014","journal-title":"PLoS One"},{"key":"2025030417544051200_r26","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic classification of cutaneous melanoma","volume":"161","author":"Cancer Genome Atlas Network","year":"2015","journal-title":"Cell"},{"key":"2025030417544051200_r27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1101\/gr.213348.116","article-title":"Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma","volume":"27","author":"Liang","year":"2017","journal-title":"Genome Res."},{"key":"2025030417544051200_r28","first-page":"204","article-title":"Genetic effects on gene expression across human tissues. [Published erratum appears in 2018 Nature 553: 530.]","volume":"550","author":"Battle","year":"2017","journal-title":"Nature"},{"key":"2025030417544051200_r29","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"2025030417544051200_r30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"2025030417544051200_r31","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2025030417544051200_r32","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2025030417544051200_r33","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"2025030417544051200_r34","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2025030417544051200_r35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2025030417544051200_r36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1471-2105-12-133","article-title":"The PathOlogist: an automated tool for pathway-centric analysis","volume":"12","author":"Greenblum","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2025030417544051200_r37","doi-asserted-by":"crossref","first-page":"e425","DOI":"10.1371\/journal.pone.0000425","article-title":"Identification of key processes underlying cancer phenotypes using biologic pathway analysis","volume":"2","author":"Efroni","year":"2007","journal-title":"PLoS One"},{"key":"2025030417544051200_r38","doi-asserted-by":"crossref","first-page":"e2901","DOI":"10.1371\/journal.pone.0002901","article-title":"Superposition of transcriptional behaviors determines gene state","volume":"3","author":"Efroni","year":"2008","journal-title":"PLoS One"},{"key":"2025030417544051200_r39","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: digitally portraying the tissue cellular heterogeneity landscape","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol."},{"key":"2025030417544051200_r40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-017-0424-2","article-title":"Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden","volume":"9","author":"Chalmers","year":"2017","journal-title":"Genome Med."},{"key":"2025030417544051200_r41","doi-asserted-by":"crossref","first-page":"661","DOI":"10.21037\/tlcr.2018.08.02","article-title":"Methods of measurement for tumor mutational burden in tumor tissue","volume":"7","author":"Mel\u00e9ndez","year":"2018","journal-title":"Transl. Lung Cancer Res."},{"key":"2025030417544051200_r42","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.AM2018-2250","article-title":"Abstract 2250: tumor mutational burden: guidelines for derivation and robustness of measurement","volume":"78","author":"Mola","year":"2018","journal-title":"Cancer Res."},{"key":"2025030417544051200_r43","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"2025030417544051200_r44","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2025030417544051200_r45","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.4049\/jimmunol.177.7.4833","article-title":"Exposure of the promonocytic cell line THP-1 to Escherichia coli induces IFN-gamma-inducible lysosomal thiol reductase expression by inflammatory cytokines","volume":"177","author":"Lackman","year":"2006","journal-title":"J. Immunol."},{"key":"2025030417544051200_r46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4049\/jimmunol.173.2.731","article-title":"Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent","volume":"173","author":"O\u2019Donnell","year":"2004","journal-title":"J. Immunol."},{"key":"2025030417544051200_r47","doi-asserted-by":"crossref","first-page":"8755","DOI":"10.1038\/ncomms9755","article-title":"MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment","volume":"6","author":"Riesenberg","year":"2015","journal-title":"Nat. Commun."},{"key":"2025030417544051200_r48","doi-asserted-by":"crossref","first-page":"14006","DOI":"10.1074\/jbc.M413692200","article-title":"MART-1 is required for the function of the melanosomal matrix protein PMEL17\/GP100 and the maturation of melanosomes","volume":"280","author":"Hoashi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025030417544051200_r49","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1046\/j.0022-202x.2001.01563.x","article-title":"Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor","volume":"117","author":"Vachtenheim","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"2025030417544051200_r50","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/(SICI)1097-0215(19990301)80:5<781::AID-IJC24>3.0.CO;2-A","article-title":"Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model","volume":"80","author":"Cormier","year":"1999","journal-title":"Int. J. Cancer"},{"key":"2025030417544051200_r51","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.aaa1348","article-title":"Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer","volume":"348","author":"Rizvi","year":"2015","journal-title":"Science"},{"key":"2025030417544051200_r52","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1056\/NEJMoa1406498","article-title":"Genetic basis for clinical response to CTLA-4 blockade in melanoma","volume":"371","author":"Snyder","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2025030417544051200_r53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.aad0095","article-title":"Genomic correlates of response to CTLA-4 blockade in metastatic melanoma","volume":"350","author":"Van Allen","year":"2015","journal-title":"Science"},{"key":"2025030417544051200_r54","doi-asserted-by":"crossref","first-page":"10582","DOI":"10.1038\/ncomms10582","article-title":"Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1\/PD-L1 therapy","volume":"7","author":"Johnson","year":"2016","journal-title":"Nat. Commun."},{"key":"2025030417544051200_r55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1365-2133.2001.04335.x","article-title":"Prognostic immunohistochemical markers of primary human melanomas","volume":"145","author":"Ostmeier","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"2025030417544051200_r56","first-page":"1019","article-title":"Level of HLA antigens in locoregional metastases and clinical course of the disease in patients with melanoma","volume":"48","author":"van Duinen","year":"1988","journal-title":"Cancer Res."},{"key":"2025030417544051200_r57","doi-asserted-by":"crossref","first-page":"a028480","DOI":"10.1101\/cshperspect.a028480","article-title":"Interferon \u03b3 and its important roles in promoting and inhibiting spontaneous and therapeutic cancer immunity","volume":"11","author":"Alspach","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2025030417544051200_r58","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.171.4.1283","article-title":"cis-acting sequences required for class II gene regulation by interferon gamma and tumor necrosis factor alpha in a murine macrophage cell line","volume":"171","author":"Freund","year":"1990","journal-title":"J. Exp. Med."},{"key":"2025030417544051200_r59","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0560.2006.00616.x","article-title":"Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance: could it be related to a different cytokine microenvironment?","volume":"34","author":"Moretti","year":"2007","journal-title":"J. Cutan. Pathol."},{"key":"2025030417544051200_r60","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1158\/1541-7786.MCR-11-0279","article-title":"Constitutive aberrant endogenous interleukin-1 facilitates inflammation and growth in human melanoma","volume":"9","author":"Qin","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"2025030417544051200_r61","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature15726","article-title":"Oxidative stress inhibits distant metastasis by human melanoma cells","volume":"527","author":"Piskounova","year":"2015","journal-title":"Nature"},{"key":"2025030417544051200_r62","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.freeradbiomed.2011.05.015","article-title":"Lysosomal thiol reductase negatively regulates autophagy by altering glutathione synthesis and oxidation","volume":"51","author":"Chiang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"2025030417544051200_r63","doi-asserted-by":"crossref","first-page":"8855","DOI":"10.1074\/jbc.M708998200","article-title":"An unexpected functional link between lysosomal thiol reductase and mitochondrial manganese superoxide dismutase","volume":"283","author":"Bogunovic","year":"2008","journal-title":"J. Biol. 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J. 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