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Generation of pDCs from bone marrow dendritic cell (DC) progenitors and their maintenance is driven by the transcription factor E2-2 and inhibited by its repressor Id2. In this study, we find that mouse pDCs selectively express the receptor for LIF that signals through STAT3. Stimulation of pDCs with LIF inhibited IFN-I, TNF, and IL-6 responses to CpG and induced expression of the STAT3 targets SOCS3 and Bcl3, which inhibit IFN-I and NF-\u03baB signaling. Moreover, although STAT3 has been also reported to induce E2-2, LIF paradoxically induced its repressor Id2. A late-stage bone marrow DC progenitor expressed low amounts of LIFR and developed into pDCs less efficiently after being exposed to LIF, consistent with the induction of Id2. Conversely, pDC development and serum IFN-I responses to lymphocytic choriomeningitis virus infection were augmented in newly generated mice lacking LIFR in either CD11c+ or hematopoietic cells. Thus, an LIF-driven STAT3 pathway induces SOCS3, Bcl3, and Id2, which render pDCs and late DC progenitors refractory to physiological stimuli controlling pDC functions and development. This pathway can be potentially exploited to prevent inappropriate secretion of IFN-I in autoimmune diseases or promote IFN-I secretion during viral infections.<\/jats:p>","DOI":"10.4049\/jimmunol.1900604","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:25:50Z","timestamp":1584145550000},"page":"2257-2268","source":"Crossref","is-referenced-by-count":18,"title":["Leukemia Inhibitory Factor Inhibits Plasmacytoid Dendritic Cell Function and Development"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7098-2850","authenticated-orcid":false,"given":"Renata","family":"Sesti-Costa","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"},{"name":"Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo ,","place":["Brazil 14049-900"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Cervantes-Barragan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa K","family":"Swiecki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1035-5193","authenticated-orcid":false,"given":"Jos\u00e9 Lu\u00eds","family":"Fachi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-1313","authenticated-orcid":false,"given":"Marina","family":"Cella","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-0996","authenticated-orcid":false,"given":"Susan","family":"Gilfillan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Santana","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, S\u00e3o Paulo ,","place":["Brazil 14049-900"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Colonna","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"2025030417511513200_r1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"Swiecki","year":"2015","journal-title":"Nat. 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Immunol."},{"key":"2025030417511513200_r37","article-title":"The regulation of leukemia inhibitory factor","volume":"2","author":"Yue","year":"2015","journal-title":"Cancer Cell Microenviron."},{"key":"2025030417511513200_r38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jneuroim.2008.07.015","article-title":"Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages","volume":"204","author":"Hendriks","year":"2008","journal-title":"J. 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Disord."},{"key":"2025030417511513200_r44","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12974-018-1326-y","article-title":"Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion","volume":"15","author":"Davis","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"2025030417511513200_r45","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.4161\/cc.8.9.8348","article-title":"Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6","volume":"8","author":"Gao","year":"2009","journal-title":"Cell Cycle"},{"key":"2025030417511513200_r46","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1182\/blood-2007-02-072587","article-title":"Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells","volume":"110","author":"Duluc","year":"2007","journal-title":"Blood"},{"key":"2025030417511513200_r47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1189\/jlb.3MA1016-451RR","article-title":"TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs","volume":"102","author":"Won","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"2025030417511513200_r48","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.4049\/jimmunol.166.3.2049","article-title":"Studies using leukemia inhibitory factor (LIF) knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation","volume":"166","author":"Zhu","year":"2001","journal-title":"J. Immunol."},{"key":"2025030417511513200_r49","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/labinvest.3700216","article-title":"Endogenous leukemia inhibitory factor attenuates endotoxin response","volume":"85","author":"Weber","year":"2005","journal-title":"Lab. Invest."},{"key":"2025030417511513200_r50","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1182\/blood-2012-07-441311","article-title":"The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development","volume":"120","author":"Li","year":"2012","journal-title":"Blood"},{"key":"2025030417511513200_r51","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.24935","article-title":"JAK-STAT3 and somatic cell reprogramming","volume":"2","author":"Tang","year":"2013","journal-title":"JAK-STAT"},{"key":"2025030417511513200_r52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ni1012","article-title":"Suppressors of cytokine signaling and immunity","volume":"4","author":"Kubo","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025030417511513200_r53","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1128\/MCB.00090-15","article-title":"SOCS3 drives proteasomal degradation of TBK1 and negatively regulates antiviral innate immunity","volume":"35","author":"Liu","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"2025030417511513200_r54","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.0903563","article-title":"Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages","volume":"185","author":"Akhtar","year":"2010","journal-title":"J. Immunol."},{"key":"2025030417511513200_r55","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1128\/JVI.01857-10","article-title":"Viral exploitation of host SOCS protein functions","volume":"85","author":"Akhtar","year":"2011","journal-title":"J. Virol."},{"key":"2025030417511513200_r56","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s10753-016-0452-x","article-title":"Role of leptin and SOCS3 in inhibiting the type I interferon response during obesity","volume":"40","author":"Ter\u00e1n-Cabanillas","year":"2017","journal-title":"Inflammation"},{"key":"2025030417511513200_r57","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ibd.21066","article-title":"Ablation of gly96\/immediate early gene-X1 (gly96\/iex-1) aggravates DSS-induced colitis in mice: role for gly96\/iex-1 in the regulation of NF-kappaB","volume":"16","author":"Sina","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"2025030417511513200_r58","first-page":"3915","article-title":"BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins","volume":"14","author":"Zhang","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"2025030417511513200_r59","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1084\/jem.20050768","article-title":"Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding","volume":"202","author":"Taggart","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025030417511513200_r60","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.20061856","article-title":"Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii","volume":"204","author":"Liu","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025030417511513200_r61","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ni.2158","article-title":"The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets","volume":"12","author":"Yang","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030417511513200_r62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1117729","article-title":"A clonogenic bone marrow progenitor specific for macrophages and dendritic cells","volume":"311","author":"Fogg","year":"2006","journal-title":"Science"},{"key":"2025030417511513200_r63","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.20061011","article-title":"Monocytes give rise to mucosal, but not splenic, conventional dendritic cells","volume":"204","author":"Varol","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025030417511513200_r64","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/ni1518","article-title":"Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow","volume":"8","author":"Onai","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025030417511513200_r65","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/dev.121.5.1283","article-title":"Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death","volume":"121","author":"Ware","year":"1995","journal-title":"Development"},{"key":"2025030417511513200_r66","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen","volume":"204","author":"Caton","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025030417511513200_r67","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1084\/jem.192.12.1775","article-title":"Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. 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