{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:16:47Z","timestamp":1790363807853,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"cience","award":["15K21649"],"award-info":[{"award-number":["15K21649"]}]},{"name":"cience","award":["17K08896"],"award-info":[{"award-number":["17K08896"]}]},{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["25-103"],"award-info":[{"award-number":["25-103"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thymic stromal lymphopoietin (TSLP) is a key cytokine that initiates and promotes allergic inflammation both in humans and mice. It is well known that TSLP is important in initial step of inflammation by stimulating dendritic cells to promote Th2 differentiation of naive T cells. However, TSLP is abundantly produced in the late phase of inflammation, as well; therefore, we focused on the function of TSLP in chronic Th2-type inflammation. By establishing a novel (to our knowledge) chronic allergic skin inflammation mouse model with repetitive challenges of hapten after sensitization, we demonstrated that CD4 T cell\u2013specific deletion of TSLP receptor (TSLPR) resulted in near-complete ablation of ear swelling and infiltration of CD4 T cells and eosinophils, but after second challenge. Of note, TSLPR deletion on CD4 T cells did not affect acute inflammation. As expected, transfer of Ag-sensitized wild-type CD4T cells, but not of TSLPR-deficient CD4T cells, increased skin inflammation in the model upon challenge. Furthermore, production of IL-4 from TSLPR-deficient CD4T cells in inflamed ear lesions was markedly diminished, demonstrating that TSLP-dependent IL-4 production from CD4T cells was critical for the exacerbation of skin inflammation. Similar results were obtained in Th2-type allergic skin inflammation model using MC903. Collectively, these results indicate that TSLP acts directly on CD4 T cells to elicit pathogenesis of Th2 cells, thereby having a critical role in exacerbation of skin inflammation in the chronic phase.<\/jats:p>","DOI":"10.4049\/jimmunol.1900758","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T22:26:46Z","timestamp":1590186406000},"page":"27-35","source":"Crossref","is-referenced-by-count":24,"title":["Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-4730","authenticated-orcid":false,"given":"Masayuki","family":"Kitajima","sequence":"first","affiliation":[{"name":"Department of Immunology and Pathology, Research Institute, National Center for Global Health and Medicine , Ichikawa-shi, Chiba 272-8516 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kubo","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science , Noda-shi, Chiba 278-8510 ,","place":["Japan"]},{"name":"Laboratory for Cytokine Regulation, Research Center for Integrative Medical Science, RIKEN Yokohama Institute , Tsurumi-ku, Yokohama 230-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Immunology Program, Benaroya Research Institute at Virginia Mason , Seattle, WA 98101-2795"},{"name":"Department of Immunology, University of Washington Medicine , Seattle, WA 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-9361","authenticated-orcid":false,"given":"Harumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathology, Research Institute, National Center for Global Health and Medicine , Ichikawa-shi, Chiba 272-8516 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2025030417504167800_r1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ni.1852","article-title":"Sensing the outside world: TSLP regulates barrier immunity","volume":"11","author":"Ziegler","year":"2010","journal-title":"Nat. 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Biol."},{"key":"2025030417504167800_r7","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/sj.leu.2402175","article-title":"Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation","volume":"15","author":"Quentmeier","year":"2001","journal-title":"Leukemia"},{"key":"2025030417504167800_r8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1084\/jem.192.5.659","article-title":"Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor","volume":"192","author":"Park","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030417504167800_r9","doi-asserted-by":"crossref","first-page":"ra4","DOI":"10.1126\/scisignal.2000567","article-title":"Distinct signal codes generate dendritic cell functional plasticity","volume":"3","author":"Arima","year":"2010","journal-title":"Sci. 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