{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:28:46Z","timestamp":1790368126622,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007525","name":"Universit\u00e9 de Rennes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The chemokine CXCL13 controls the normal organization of secondary lymphoid tissues and the neogenesis of ectopic lymphoid structures in nonlymphoid organs, particularly the lungs. The progression and severity of idiopathic pulmonary fibrosis (IPF), a fatal and irreversible interstitial lung disease, is predicted by the circulating blood concentrations of CXCL13. Although CXCL13 is produced by pulmonary tissues, it has not been determined which cells are involved. This study examines CXCL13 production by lung tissue macrophages from patients with IPF and the signaling pathways controlling CXCL13 gene expression in human alveolar macrophages (AM) and monocyte-derived macrophages (MoDM). CXCL13 is found in CD68- and CD206-positive AM from patients with IPF, and the CXCL13 gene is induced in these macrophages and MoDM when they are stimulated with LPS. We found that TNF-\u03b1 and IL-10 control optimal CXCL13 gene expression in MoDM and possibly in AM by activating the NF-\u03baB and JAK\/STAT pathways, respectively. We also found that blood TNF-\u03b1 and CXCL13 concentrations are significantly correlated in patients with IPF, suggesting that TNF-\u03b1 contributes to CXCL13 production in humans. In conclusion, the results of this study demonstrate that AM from patients with IPF produces CXCL13 and that the NF-\u03baB and JAK\/STAT pathways are required to induce the expression of this major chemokine.<\/jats:p>","DOI":"10.4049\/jimmunol.1900790","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T21:05:54Z","timestamp":1585170354000},"page":"2492-2502","source":"Crossref","is-referenced-by-count":61,"title":["TNF-\u03b1 and IL-10 Control CXCL13 Expression in Human Macrophages"],"prefix":"10.1093","volume":"204","author":[{"given":"Nessrine","family":"Bellamri","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Rennes, INSERM, EHESP, Institut de Recherche en Sant\u00e9, Environnement et Travail - UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselyne","family":"Viel","sequence":"additional","affiliation":[{"name":"Plateforme d'Histopathologie de Haute Pr\u00e9cision (H2P2), Universit\u00e9 de Rennes , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudie","family":"Morzadec","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rennes, INSERM, EHESP, Institut de Recherche en Sant\u00e9, Environnement et Travail - UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lecureur","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rennes, INSERM, EHESP, Institut de Recherche en Sant\u00e9, Environnement et Travail - UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Joannes","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rennes, INSERM, EHESP, Institut de Recherche en Sant\u00e9, Environnement et Travail - UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"de Latour","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardio-Thoracique et Vasculaire, Centre Hospitalier Universitaire , 35033 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Llamas-Gutierrez","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomopathologie, Centre Hospitalier Universitaire , 35033 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-5772","authenticated-orcid":false,"given":"Lutz","family":"Wollin","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim , 88397 Biberach an der Riss ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1949-3461","authenticated-orcid":false,"given":"St\u00e9phane","family":"Jouneau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rennes, Centre Hospitalier Universitaire de Rennes, INSERM, EHESP, Institut de Recherche en Sant\u00e9, Environnement et Travail - UMR_S 1085 , 35000 Rennes ,","place":["France"]},{"name":"Service de Pneumologie, Centre de Comp\u00e9tences pour les Maladies Pulmonaires Rares de Bretagne, Centre Hospitalier Universitaire , 35033 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Vernhet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rennes, INSERM, EHESP, Institut de Recherche en Sant\u00e9, Environnement et Travail - UMR_S 1085 , 35000 Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"2025030417511691300_r1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1034\/j.1600-065X.2000.00618.x","article-title":"Follicular stromal cells and lymphocyte homing to follicles","volume":"176","author":"Cyster","year":"2000","journal-title":"Immunol. 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