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Interstitial and cerebrospinal fluid produced in the CNS is continuously drained, and recent advances have emphasized that this process is largely taking place through the lymphatic system. To what extent this fluid process mobilizes CNS-derived Ags toward meningeal immune cells and subsequently the peripheral immune system through the lymphatic vessel network is a question of significant clinical importance for autoimmunity, tumor immunology, and infectious disease. Recent advances in understanding the role of meningeal lymphatics as a communicator between the brain and peripheral immunity are discussed in this review.<\/jats:p>","DOI":"10.4049\/jimmunol.1900838","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T21:25:29Z","timestamp":1578345929000},"page":"286-293","source":"Crossref","is-referenced-by-count":110,"title":["Meningeal Lymphatics: From Anatomy to Central Nervous System Immune Surveillance"],"prefix":"10.1093","volume":"204","author":[{"given":"Zachary","family":"Papadopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Herz","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia, Neuroscience Graduate Program, Department of Neuroscience, University of Virginia , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-517X","authenticated-orcid":false,"given":"Jonathan","family":"Kipnis","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia, Neuroscience Graduate Program, Department of Neuroscience, University of Virginia , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"2025030417510356800_r1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/cmi.2014.38","article-title":"Testicular defense systems: immune privilege and innate immunity","volume":"11","author":"Zhao","year":"2014","journal-title":"Cell. 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