{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:03:17Z","timestamp":1777053797665,"version":"3.51.4"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NK cells play an important role in antiviral resistance. The integrin \u03b12, which dimerizes with integrin \u03b21, distinguishes NK cells from innate lymphoid cells 1 and other leukocytes. Despite its use as an NK cell marker, little is known about the role of \u03b12\u03b21 in NK cell biology. In this study, we show that in mice \u03b12\u03b21 deficiency does not alter the balance of NK cell\/ innate lymphoid cell 1 generation and slightly decreases the number of NK cells in the bone marrow and spleen without affecting NK cell maturation. NK cells deficient in \u03b12\u03b21 had no impairment at entering or distributing within the draining lymph node of ectromelia virus (ECTV)\u2013infected mice or at becoming effectors but proliferated poorly in response to ECTV and did not increase in numbers following infection with mouse CMV (MCMV). Still, \u03b12\u03b21-deficient NK cells efficiently protected from lethal mousepox and controlled MCMV titers in the spleen. Thus, \u03b12\u03b21 is required for optimal NK cell proliferation but is dispensable for protection against ECTV and MCMV, two well-established models of viral infection in which NK cells are known to be important.<\/jats:p>","DOI":"10.4049\/jimmunol.1900927","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T19:25:14Z","timestamp":1580757914000},"page":"1582-1591","source":"Crossref","is-referenced-by-count":13,"title":["\u03b12\u03b21 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell\u2013Mediated Virus Control"],"prefix":"10.1093","volume":"204","author":[{"given":"Colby","family":"Stotesbury","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-6838","authenticated-orcid":false,"given":"Pedro","family":"Alves-Peixoto","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-2911","authenticated-orcid":false,"given":"Brian","family":"Montoya","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ferez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-0459","authenticated-orcid":false,"given":"Savita","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-7198","authenticated-orcid":false,"given":"Christopher M","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunchuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory J","family":"Knudson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-5472","authenticated-orcid":false,"given":"Luis J","family":"Sigal","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,15]]},"reference":[{"key":"2025030417511182900_r1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S095279150200002X","article-title":"Natural killer cells and viral infections","volume":"15","author":"French","year":"2003","journal-title":"Curr. 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