{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:30:48Z","timestamp":1790937048448,"version":"4.1.0"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["TMA2016SF-1535-CaTCH-22"],"award-info":[{"award-number":["TMA2016SF-1535-CaTCH-22"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203135\/Z\/16\/Z"],"award-info":[{"award-number":["203135\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["TMA2017SF-1951-TB-SPEC"],"award-info":[{"award-number":["TMA2017SF-1951-TB-SPEC"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104803"],"award-info":[{"award-number":["104803"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01 AI115940"],"award-info":[{"award-number":["U01 AI115940"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010438","name":"Francis Crick Institute","doi-asserted-by":"publisher","award":["FC0010218"],"award-info":[{"award-number":["FC0010218"]}],"id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006312","name":"NRF | South African Agency for Science and Technology Advancement","doi-asserted-by":"publisher","award":["92755"],"award-info":[{"award-number":["92755"]}],"id":[{"id":"10.13039\/501100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006312","name":"NRF | South African Agency for Science and Technology Advancement","doi-asserted-by":"publisher","award":["96841"],"award-info":[{"award-number":["96841"]}],"id":[{"id":"10.13039\/501100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["TMA2020CDF-3187"],"award-info":[{"award-number":["TMA2020CDF-3187"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>HIV-1 infection substantially increases the risk of developing tuberculosis (TB). Mechanisms such as defects in the Th1 response to Mycobacterium tuberculosis in HIV-infected persons have been widely reported. However, Th1-independent mechanisms also contribute to protection against TB. To identify a broader spectrum of defects in TB immunity during HIV infection, we examined IL-17A and IL-22 production in response to mycobacterial Ags in peripheral blood of persons with latent TB infection and HIV coinfection. Upon stimulating with mycobacterial Ags, we observed a distinct CD4+ Th lineage producing IL-22 in the absence of IL-17A and IFN-\u03b3. Mycobacteria-specific Th22 cells were present at high frequencies in blood and contributed up to 50% to the CD4+ T cell response to mycobacteria, comparable in magnitude to the IFN-\u03b3 Th1 response (median 0.91% and 0.55%, respectively). Phenotypic characterization of Th22 cells revealed that their memory differentiation was similar to M. tuberculosis\u2013specific Th1 cells (i.e., predominantly early differentiated CD45RO+CD27+ phenotype). Moreover, CCR6 and CXCR3 expression profiles of Th22 cells were similar to Th17 cells, whereas their CCR4 and CCR10 expression patterns displayed an intermediate phenotype between Th1 and Th17 cells. Strikingly, mycobacterial IL-22 responses were 3-fold lower in HIV-infected persons compared with uninfected persons, and the magnitude of responses correlated inversely with HIV viral load. These data provide important insights into mycobacteria-specific Th subsets in humans and suggest a potential role for IL-22 in protection against TB during HIV infection. Further studies are needed to fully elucidate the role of IL-22 in protective TB immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1900984","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T14:55:13Z","timestamp":1628866513000},"page":"1239-1249","source":"Crossref","is-referenced-by-count":21,"title":["Th22 Cells Are a Major Contributor to the Mycobacterial CD4+ T Cell Response and Are Depleted During HIV Infection"],"prefix":"10.1093","volume":"207","author":[{"given":"Rubina","family":"Bunjun","sequence":"first","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidilia M A","family":"Omondi","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-8445","authenticated-orcid":false,"given":"Mohau S","family":"Makatsa","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roanne","family":"Keeton","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome M","family":"Wendoh","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey L","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn S L","family":"Prentice","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Medicine, Imperial College London , London ,","place":["United Kingdom"]},{"name":"The Francis Crick Institute , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-0745","authenticated-orcid":false,"given":"Catherine","family":"Riou","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-9398","authenticated-orcid":false,"given":"Wendy A","family":"Burgers","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Department of Pathology, University of Cape Town , Cape Town ,","place":["South Africa"]},{"name":"Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"2025022610320819000_r1","volume-title":"Global Tuberculosis Report.","author":"World Health Organization","year":"2020"},{"key":"2025022610320819000_r2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1086\/318706","article-title":"A review of efficacy studies of 6-month short-course therapy for tuberculosis among patients infected with human immunodeficiency virus: differences in study outcomes","volume":"32","author":"El-Sadr","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"2025022610320819000_r3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev-immunol-042617-053420","article-title":"The immune response to Mycobacterium tuberculosis in HIV-1-coinfected persons","volume":"36","author":"Esmail","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"2025022610320819000_r4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1473-3099(17)30703-X","article-title":"The global burden of tuberculosis: results from the Global Burden of Disease Study 2015","volume":"18","author":"GBD Tuberculosis Collaborators","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"2025022610320819000_r5","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1097\/QAD.0b013e32832d3b6d","article-title":"Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa","volume":"23","author":"Lawn","year":"2009","journal-title":"AIDS"},{"key":"2025022610320819000_r6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.coi.2014.06.003","article-title":"Defining features of protective CD4 T cell responses to Mycobacterium tuberculosis","volume":"29","author":"Sakai","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"2025022610320819000_r7","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1056\/NEJMoa1803484","article-title":"Phase 2b controlled trial of M72\/AS01E vaccine to prevent tuberculosis","volume":"379","author":"Van Der Meeren","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"2025022610320819000_r8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O\u2019Garra","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"2025022610320819000_r9","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1086\/593017","article-title":"Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection","volume":"198","author":"Geldmacher","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2025022610320819000_r10","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1084\/jem.20100090","article-title":"Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection","volume":"207","author":"Geldmacher","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025022610320819000_r11","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.4049\/jimmunol.1700558","article-title":"HIV-1 infection is associated with depletion and functional impairment of Mycobacterium tuberculosis\u2013specific CD4 T cells in individuals with latent tuberculosis infection","volume":"199","author":"Day","year":"2017","journal-title":"J. Immunol."},{"key":"2025022610320819000_r12","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.4049\/jimmunol.1700849","article-title":"Characterization of Mycobacterium tuberculosis\u2013specific cells using MHC class II tetramers reveals phenotypic differences related to HIV infection and tuberculosis disease","volume":"199","author":"Strickland","year":"2017","journal-title":"J. Immunol."},{"key":"2025022610320819000_r13","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1164\/rccm.200907-1011OC","article-title":"HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria","volume":"180","author":"Kalsdorf","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025022610320819000_r14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/thx.2010.153825","article-title":"Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults","volume":"66","author":"Jambo","year":"2011","journal-title":"Thorax"},{"key":"2025022610320819000_r15","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/infdis\/jix529","article-title":"Effect of HIV on the frequency and number of Mycobacterium tuberculosis-specific CD4 + T Cells in blood and airways during latent M. tuberculosis infection","volume":"216","author":"Bunjun","year":"2017","journal-title":"J. Infect. Dis."},{"key":"2025022610320819000_r16","doi-asserted-by":"crossref","first-page":"e1002052","DOI":"10.1371\/journal.ppat.1002052","article-title":"A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo","volume":"7","author":"Gallegos","year":"2011","journal-title":"PLoS Pathog."},{"key":"2025022610320819000_r17","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.4049\/jimmunol.1502094","article-title":"HIV skews the lineage-defining transcriptional profile of Mycobacterium tuberculosis-specific CD4+ T cells","volume":"196","author":"Riou","year":"2016","journal-title":"J. Immunol."},{"key":"2025022610320819000_r18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/cmi.2017.128","article-title":"The crucial roles of Th17-related cytokines\/signal pathways in M. tuberculosis infection","volume":"15","author":"Shen","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"2025022610320819000_r19","doi-asserted-by":"crossref","first-page":"e1006687","DOI":"10.1371\/journal.ppat.1006687","article-title":"Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease","volume":"13","author":"Scriba","year":"2017","journal-title":"PLoS Pathog."},{"key":"2025022610320819000_r20","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/infdis\/jiy052","article-title":"Human immunodeficiency virus infection impairs Th1 and Th17 Mycobacterium tuberculosis\u2013specific T cell responses","volume":"217","author":"Murray","year":"2018","journal-title":"J. Infect. Dis."},{"key":"2025022610320819000_r21","doi-asserted-by":"crossref","first-page":"e1004099","DOI":"10.1371\/journal.ppat.1004099","article-title":"Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection","volume":"10","author":"Gopal","year":"2014","journal-title":"PLoS Pathog."},{"key":"2025022610320819000_r22","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/eji.201141569","article-title":"IL-23-dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccination","volume":"42","author":"Gopal","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2025022610320819000_r23","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/mi.2012.135","article-title":"Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis","volume":"6","author":"Gopal","year":"2013","journal-title":"Mucosal Immunol."},{"key":"2025022610320819000_r24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025022610320819000_r25","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.4049\/jimmunol.0903332","article-title":"Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung","volume":"184","author":"Okamoto Yoshida","year":"2010","journal-title":"J. Immunol."},{"key":"2025022610320819000_r26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.92973","article-title":"Interleukin-17 limits hypoxia-inducible factor 1\u03b1 and development of hypoxic granulomas during tuberculosis","volume":"2","author":"Domingo-Gonzalez","year":"2017","journal-title":"JCI Insight"},{"key":"2025022610320819000_r27","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J. Exp. Med."},{"key":"2025022610320819000_r28","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1767","article-title":"Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells","volume":"10","author":"Duhen","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025022610320819000_r29","first-page":"3573","article-title":"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling","volume":"119","author":"Eyerich","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2025022610320819000_r30","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","article-title":"Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells","volume":"10","author":"Trifari","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025022610320819000_r31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025022610320819000_r32","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.4049\/jimmunol.0903416","article-title":"Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections","volume":"184","author":"Wilson","year":"2010","journal-title":"J. Immunol."},{"key":"2025022610320819000_r33","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.4049\/jimmunol.1101377","article-title":"IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung","volume":"187","author":"Khader","year":"2011","journal-title":"J. Immunol."},{"key":"2025022610320819000_r34","doi-asserted-by":"crossref","first-page":"e57379","DOI":"10.1371\/journal.pone.0057379","article-title":"IL-22 is mainly produced by IFN\u03b3-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection","volume":"8","author":"Behrends","year":"2013","journal-title":"PLoS One"},{"key":"2025022610320819000_r35","doi-asserted-by":"crossref","first-page":"36923","DOI":"10.1038\/srep36923","article-title":"Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNF\u03b1 neutralization","volume":"6","author":"Segueni","year":"2016","journal-title":"Sci. Rep."},{"key":"2025022610320819000_r36","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/mi.2017.15","article-title":"Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection","volume":"10","author":"Treerat","year":"2017","journal-title":"Mucosal Immunol."},{"key":"2025022610320819000_r37","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/mi.2012.72","article-title":"A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis","volume":"5","author":"Kim","year":"2012","journal-title":"Mucosal Immunol."},{"key":"2025022610320819000_r38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jim.2004.06.010","article-title":"Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies","volume":"291","author":"Hanekom","year":"2004","journal-title":"J. Immunol. Methods"},{"key":"2025022610320819000_r39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"key":"2025022610320819000_r40","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.4049\/jimmunol.1400019","article-title":"Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cells","volume":"192","author":"Sakai","year":"2014","journal-title":"J. Immunol."},{"key":"2025022610320819000_r41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/intimm\/11.3.417","article-title":"CD26\/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response","volume":"11","author":"Iwata","year":"1999","journal-title":"Int. Immunol."},{"key":"2025022610320819000_r42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0008-8749(02)00010-2","article-title":"Soluble CD26\/dipeptidyl peptidase IV enhances transendothelial migration via its interaction with mannose 6-phosphate\/insulin-like growth factor II receptor","volume":"215","author":"Ikushima","year":"2002","journal-title":"Cell. Immunol."},{"key":"2025022610320819000_r43","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4049\/jimmunol.180.3.1962","article-title":"Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response","volume":"180","author":"Scriba","year":"2008","journal-title":"J. Immunol."},{"key":"2025022610320819000_r44","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1164\/rccm.201107-1198OC","article-title":"Differentiation and recruitment of IL-22-producing helper T cells stimulated by pleural mesothelial cells in tuberculous pleurisy","volume":"185","author":"Ye","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025022610320819000_r45","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.4049\/jimmunol.164.4.1814","article-title":"Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9","volume":"164","author":"Dumoutier","year":"2000","journal-title":"J. Immunol."},{"key":"2025022610320819000_r46","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1128\/IAI.01392-09","article-title":"Mycobacterium bovis BCG-specific Th17 cells confer partial protection against Mycobacterium tuberculosis infection in the absence of gamma interferon","volume":"78","author":"Wozniak","year":"2010","journal-title":"Infect. Immun."},{"key":"2025022610320819000_r47","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/imm.12130","article-title":"Mice genetically inactivated in interleukin-17A receptor are defective in long-term control of Mycobacterium tuberculosis infection","volume":"140","author":"Freches","year":"2013","journal-title":"Immunology"},{"key":"2025022610320819000_r48","doi-asserted-by":"crossref","first-page":"e1004603","DOI":"10.1371\/journal.ppat.1004603","article-title":"Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization","volume":"11","author":"Gideon","year":"2015","journal-title":"PLoS Pathog."},{"key":"2025022610320819000_r49","doi-asserted-by":"crossref","first-page":"e137858","DOI":"10.1172\/jci.insight.137858","article-title":"Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment","volume":"5","author":"Shanmugasundaram","year":"2020","journal-title":"JCI Insight"},{"key":"2025022610320819000_r50","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.aaa4282","article-title":"IMMUNODEFICIENCIES: Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations","volume":"349","author":"Okada","year":"2015","journal-title":"Science"},{"key":"2025022610320819000_r51","doi-asserted-by":"crossref","first-page":"28586","DOI":"10.1038\/srep28586","article-title":"Genetic polymorphisms of IL-17A, IL-17F, TLR4 and miR-146a in association with the risk of pulmonary tuberculosis","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"2025022610320819000_r52","doi-asserted-by":"crossref","first-page":"142014","DOI":"10.1172\/JCI142014","article-title":"Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung","volume":"131","author":"Ogongo","year":"2021","journal-title":"J. Clin. Invest."},{"key":"2025022610320819000_r53","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/path.5013","article-title":"Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis","volume":"244","author":"Singh","year":"2018","journal-title":"J. Pathol."},{"key":"2025022610320819000_r54","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/eji.200839090","article-title":"IL-17 and anti-bacterial immunity: protection versus tissue damage","volume":"39","author":"Cooper","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2025022610320819000_r55","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/infdis\/jir460","article-title":"Outbreaks of mycobacterium tuberculosis MDR strains induce high IL-17 T-cell response in patients with MDR tuberculosis that is closely associated with high antigen load","volume":"204","author":"Basile","year":"2011","journal-title":"J. Infect. Dis."},{"key":"2025022610320819000_r56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.imlet.2012.12.008","article-title":"Depletion of IL-22 during culture enhanced antigen-driven IFN-\u03b3 production by CD4(+)T cells from patients with active TB","volume":"150","author":"Qiu","year":"2013","journal-title":"Immunol. Lett."},{"key":"2025022610320819000_r57","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tube.2011.06.009","article-title":"Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis","volume":"91","author":"Matthews","year":"2011","journal-title":"Tuberculosis (Edinb.)"},{"key":"2025022610320819000_r58","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1164\/rccm.201210-1934OC","article-title":"Regulatory T cells attenuate mycobacterial stasis in alveolar and blood-derived macrophages from patients with tuberculosis","volume":"187","author":"Semple","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025022610320819000_r59","doi-asserted-by":"crossref","first-page":"e1000789","DOI":"10.1371\/journal.ppat.1000789","article-title":"Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis","volume":"6","author":"Yao","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025022610320819000_r60","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/srep00020","article-title":"An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese","volume":"1","author":"Zhang","year":"2011","journal-title":"Sci. Rep."},{"key":"2025022610320819000_r61","doi-asserted-by":"crossref","first-page":"e30626","DOI":"10.1371\/journal.pone.0030626","article-title":"Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers","volume":"7","author":"Aranday-Cortes","year":"2012","journal-title":"PLoS One"},{"key":"2025022610320819000_r62","doi-asserted-by":"crossref","first-page":"e1003077","DOI":"10.1371\/journal.ppat.1003077","article-title":"Global gene transcriptome analysis in vaccinated cattle revealed a dominant role of IL-22 for protection against bovine tuberculosis","volume":"8","author":"Bhuju","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025022610320819000_r63","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.immuni.2012.08.024","article-title":"Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria","volume":"37","author":"Basu","year":"2012","journal-title":"Immunity"},{"key":"2025022610320819000_r64","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Zheng","year":"2008","journal-title":"Nat. Med."},{"key":"2025022610320819000_r65","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nm1710","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia","volume":"14","author":"Aujla","year":"2008","journal-title":"Nat. Med."},{"key":"2025022610320819000_r66","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2119\/molmed.2013.00115","article-title":"Interleukin-22 promotes T helper 1 (Th1)\/Th17 immunity in chlamydial lung infection","volume":"20","author":"Peng","year":"2014","journal-title":"Mol. Med."},{"key":"2025022610320819000_r67","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00109-009-0448-1","article-title":"IL-22: a critical mediator in mucosal host defense","volume":"87","author":"Aujla","year":"2009","journal-title":"J. Mol. Med. (Berl.)"},{"key":"2025022610320819000_r68","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.4049\/jimmunol.0902587","article-title":"IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion","volume":"183","author":"Dhiman","year":"2009","journal-title":"J. Immunol."},{"key":"2025022610320819000_r69","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.1004129","article-title":"Membrane-bound IL-22 after de novo production in tuberculosis and anti-Mycobacterium tuberculosis effector function of IL-22+ CD4+ T cells","volume":"187","author":"Zeng","year":"2011","journal-title":"J. Immunol."},{"key":"2025022610320819000_r70","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/infdis\/jit495","article-title":"Interleukin 22 inhibits intracellular growth of Mycobacterium tuberculosis by enhancing calgranulin A expression","volume":"209","author":"Dhiman","year":"2014","journal-title":"J. Infect. Dis."},{"key":"2025022610320819000_r71","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1182\/blood-2008-05-159301","article-title":"Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections","volume":"112","author":"Brenchley","year":"2008","journal-title":"Blood"},{"key":"2025022610320819000_r72","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/COH.0b013e3283364846","article-title":"Th17 cell dynamics in HIV infection","volume":"5","author":"Klatt","year":"2010","journal-title":"Curr. Opin. HIV AIDS"},{"key":"2025022610320819000_r73","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/QAI.0000000000000294","article-title":"Loss of Th22 cells is associated with increased immune activation and IDO-1 activity in HIV-1 infection","volume":"67","author":"Page","year":"2014","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"2025022610320819000_r74","doi-asserted-by":"crossref","first-page":"e1005412","DOI":"10.1371\/journal.ppat.1005412","article-title":"Loss of function of intestinal IL-17 and IL-22 producing cells contributes to inflammation and viral persistence in SIV-infected rhesus macaques","volume":"12","author":"Ryan","year":"2016","journal-title":"PLoS Pathog."},{"key":"2025022610320819000_r75","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4049\/jimmunol.0903058","article-title":"Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection","volume":"184","author":"Gosselin","year":"2010","journal-title":"J. Immunol."},{"key":"2025022610320819000_r76","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/QAD.0000000000001309","article-title":"HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy","volume":"31","author":"Gosselin","year":"2017","journal-title":"AIDS"},{"key":"2025022610320819000_r77","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.4049\/jimmunol.1004151","article-title":"Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin \u03b27","volume":"186","author":"Monteiro","year":"2011","journal-title":"J. Immunol."},{"key":"2025022610320819000_r78","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1128\/JVI.01838-13","article-title":"Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands","volume":"87","author":"Alvarez","year":"2013","journal-title":"J. Virol."},{"key":"2025022610320819000_r79","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/1742-4690-10-160","article-title":"Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication","volume":"10","author":"Bernier","year":"2013","journal-title":"Retrovirology"},{"key":"2025022610320819000_r80","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12977-015-0226-9","article-title":"Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach","volume":"12","author":"Cleret-Buhot","year":"2015","journal-title":"Retrovirology"},{"key":"2025022610320819000_r81","doi-asserted-by":"crossref","first-page":"e93230","DOI":"10.1172\/jci.insight.93230","article-title":"HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms","volume":"2","author":"Planas","year":"2017","journal-title":"JCI Insight"},{"key":"2025022610320819000_r82","doi-asserted-by":"crossref","first-page":"32ra36","DOI":"10.1126\/scitranslmed.3000632","article-title":"Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease","volume":"2","author":"Favre","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"2025022610320819000_r83","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/mi.2012.38","article-title":"Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection","volume":"5","author":"Klatt","year":"2012","journal-title":"Mucosal Immunol."},{"key":"2025022610320819000_r84","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1378\/chest.122.2.597","article-title":"Reconstitution of immune responses to tuberculosis in patients with HIV infection who receive antiretroviral therapy","volume":"122","author":"Schluger","year":"2002","journal-title":"Chest"},{"key":"2025022610320819000_r85","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1164\/rccm.201405-0864OC","article-title":"Asymptomatic HIV-infected individuals on antiretroviral therapy exhibit impaired lung CD4(+) T-cell responses to mycobacteria","volume":"190","author":"Jambo","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025022610320819000_r86","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1164\/rccm.200904-0568OC","article-title":"Dissection of regenerating T-cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis","volume":"180","author":"Wilkinson","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025022610320819000_r87","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.4049\/jimmunol.1500803","article-title":"Restoration of CD4+ responses to copathogens in HIV-infected individuals on antiretroviral therapy is dependent on t cell memory phenotype","volume":"195","author":"Riou","year":"2015","journal-title":"J. Immunol."},{"key":"2025022610320819000_r88","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1084\/jem.20092054","article-title":"Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A","volume":"207","author":"Sonnenberg","year":"2010","journal-title":"J. Exp. Med."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/207\/5\/1239\/61875803\/ji1900984.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/207\/5\/1239\/61875803\/ji1900984.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:34:37Z","timestamp":1740548077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/207\/5\/1239\/7944339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":88,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1900984","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/732263","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9]]},"published":{"date-parts":[[2021,9,1]]}}}