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Using a mouse model of GBS-induced peritonitis, we show in this study that the chemokines Cxcl1 and Cxcl2 play distinctive roles in enhancing the recruitment and the antibacterial activities of neutrophils in a manner that is linked to differences in the cellular sources of these mediators. Cell depletion experiments demonstrated that neutrophils make a significant contribution to the in vivo production of Cxcl2 but not Cxcl1. In vitro, neutrophils responded weakly to LPS but released high levels of Cxcl2 after stimulation with GBS or other bacteria. Neutrophil-derived Cxcl2 acted in an autocrinous manner to increase its own production and to enhance antibacterial activities, including the release of oxygen radicals. In both neutrophils and macrophages, the production of Cxcl1\/2 largely required the presence of functional UNC93B1, a chaperone protein involved in signaling by endosomal TLRs. Moreover, the phenotype of UNC93B1-defective phagocytes could be recapitulated by the simultaneous absence of TLR7, 9, and 13 but not by the absence of individual TLRs. Collectively, our data show that neutrophils recognize Gram-positive and Gram-negative bacteria by means of multiple phagosomal TLRs, resulting in de novo synthesis of Cxcl2, amplification of neutrophil recruitment, and potentiation of their antibacterial activities. These data may be useful to devise alternative therapeutic strategies aimed at enhancing the recruitment and the functional activities of polymorphonuclear leukocytes during infections caused by antibiotic-resistant bacteria.<\/jats:p>","DOI":"10.4049\/jimmunol.1901039","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T22:45:14Z","timestamp":1576709114000},"page":"660-670","source":"Crossref","is-referenced-by-count":44,"title":["Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-4476","authenticated-orcid":false,"given":"Germana","family":"Lentini","sequence":"first","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-8660","authenticated-orcid":false,"given":"Agata","family":"Fam\u00e0","sequence":"additional","affiliation":[{"name":"Charybdis Vaccines Srl , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Biondo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Galbo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical Sciences and Environmental Sciences, University of Messina , 98166 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Iannello","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiana","family":"Zummo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-4526","authenticated-orcid":false,"given":"Miriam","family":"Giardina","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-8871","authenticated-orcid":false,"given":"Giuseppe Valerio","family":"De Gaetano","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-8644","authenticated-orcid":false,"given":"Giuseppe","family":"Teti","sequence":"additional","affiliation":[{"name":"Charybdis Vaccines Srl , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-1337","authenticated-orcid":false,"given":"Concetta","family":"Beninati","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]},{"name":"Scylla Biotech SRL , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Midiri","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, University of Messina , 98125 Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,1]]},"reference":[{"key":"2025030417510564500_r1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.tim.2006.11.009","article-title":"Neutrophils and intracellular pathogens: beyond phagocytosis and killing","volume":"15","author":"Appelberg","year":"2007","journal-title":"Trends Microbiol."},{"key":"2025030417510564500_r2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. 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Immunol."},{"key":"2025030417510564500_r6","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.4049\/jimmunol.173.3.1994","article-title":"Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens","volume":"173","author":"Tvinnereim","year":"2004","journal-title":"J. Immunol."},{"key":"2025030417510564500_r7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature"},{"key":"2025030417510564500_r8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-065X.2000.17706.x","article-title":"The neutrophil as a cellular source of chemokines","volume":"177","author":"Scapini","year":"2000","journal-title":"Immunol. Rev."},{"key":"2025030417510564500_r9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.113.007724","article-title":"International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. [Published erratum appears in 2014 Pharmacol. Rev. 66: 467.]","volume":"66","author":"Bachelerie","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"2025030417510564500_r10","first-page":"414","article-title":"Anti-inflammatory drug development: broad or specific chemokine receptor antagonists?","volume":"13","author":"Russo","year":"2010","journal-title":"Curr. Opin. Drug Discov. 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Immunol."},{"key":"2025030417510564500_r14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/1744666X.2014.894886","article-title":"The CXCL8\/IL-8 chemokine family and its receptors in inflammatory diseases","volume":"10","author":"Russo","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"2025030417510564500_r15","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.GPP3-0007-2018","article-title":"Group B Streptococcus (Streptococcus agalactiae)","volume":"7","author":"Raabe","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"2025030417510564500_r16","doi-asserted-by":"crossref","first-page":"D7","DOI":"10.1016\/j.vaccine.2013.01.009","article-title":"An overview of global GBS epidemiology","volume":"31","author":"Le Doare","year":"2013","journal-title":"Vaccine"},{"key":"2025030417510564500_r17","first-page":"169","article-title":"Effects of intrapartum antibiotic prophylaxis on neonatal acquisition of group B streptococci","volume-title":"J. Pediatr.","author":"Toyofuku","year":"2017"},{"key":"2025030417510564500_r18","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofy030","article-title":"Obesity, diabetes, and the risk of invasive group B streptococcal disease in nonpregnant adults in the United States","volume":"5","author":"Pitts","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"2025030417510564500_r19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jinf.2018.07.009","article-title":"Community-acquired group B streptococcal meningitis in adults: 33 cases from prospective cohort studies","volume":"78","author":"van Kassel","year":"2019","journal-title":"J. Infect."},{"key":"2025030417510564500_r20","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01428-14","article-title":"Essential role of interleukin-1 signaling in host defenses against group B streptococcus","volume":"5","author":"Biondo","year":"2014","journal-title":"MBio"},{"key":"2025030417510564500_r21","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1128\/IAI.02282-14","article-title":"Role of toll-like receptor 13 in innate immune recognition of group B streptococci","volume":"82","author":"Signorino","year":"2014","journal-title":"Infect. Immun."},{"key":"2025030417510564500_r22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1128\/iai.61.1.227-235.1993","article-title":"Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection","volume":"61","author":"Teti","year":"1993","journal-title":"Infect. Immun."},{"key":"2025030417510564500_r23","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1128\/iai.64.8.2941-2944.1996","article-title":"Role of gamma interferon in a neonatal mouse model of group B streptococcal disease","volume":"64","author":"Cusumano","year":"1996","journal-title":"Infect. Immun."},{"key":"2025030417510564500_r24","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.4049\/jimmunol.172.10.6324","article-title":"Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease","volume":"172","author":"Mancuso","year":"2004","journal-title":"J. Immunol."},{"key":"2025030417510564500_r25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ni.1733","article-title":"Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells","volume":"10","author":"Mancuso","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030417510564500_r26","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.4049\/jimmunol.178.5.3126","article-title":"Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria","volume":"178","author":"Mancuso","year":"2007","journal-title":"J. Immunol."},{"issue":"4","key":"2025030417510564500_r27","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.ajog.2015.08.040","article-title":"Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance","volume":"213","author":"Kim","year":"2015","journal-title":"Am. J. Obstet. 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Microbiol."},{"key":"2025030417510564500_r30","doi-asserted-by":"crossref","first-page":"e417","DOI":"10.1542\/neo.5-10-e417","article-title":"Neutrophil function in preterm and term infants","volume":"5","author":"Urlichs","year":"2004","journal-title":"NeoReviews"},{"key":"2025030417510564500_r31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0022-3476(88)80394-9","article-title":"Neutrophil storage pool depletion in neonates with sepsis and neutropenia","volume":"113","author":"Engle","year":"1988","journal-title":"J. Pediatr."},{"key":"2025030417510564500_r32","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1128\/IAI.02104-14","article-title":"The interleukin-1\u03b2\/CXCL1\/2\/neutrophil axis mediates host protection against group B streptococcal infection","volume":"82","author":"Biondo","year":"2014","journal-title":"Infect. 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Methods"},{"key":"2025030417510564500_r37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036588","article-title":"Protective activity of Streptococcus pneumoniae Spr1875 protein fragments identified using a phage displayed genomic library","volume":"7","author":"Cardaci","year":"2012","journal-title":"PLoS One"},{"key":"2025030417510564500_r38","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1182\/blood-2002-07-2346","article-title":"G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells","volume":"101","author":"M\u00f3csai","year":"2003","journal-title":"Blood"},{"key":"2025030417510564500_r39","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1073\/pnas.1217039110","article-title":"Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells","volume":"110","author":"Hiramoto","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417510564500_r40","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.4049\/jimmunol.0904189","article-title":"Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo","volume":"184","author":"Mayer-Barber","year":"2010","journal-title":"J. Immunol."},{"key":"2025030417510564500_r41","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1189\/jlb.0407247","article-title":"Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice","volume":"83","author":"Daley","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"2025030417510564500_r42","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1182\/blood-2013-02-486217","article-title":"Mast cell and macrophage chemokines CXCL1\/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation","volume":"121","author":"De Filippo","year":"2013","journal-title":"Blood"},{"key":"2025030417510564500_r43","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/JID.2015.410","article-title":"Neutrophils self-regulate immune complex-mediated cutaneous inflammation through CXCL2","volume":"136","author":"Li","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"2025030417510564500_r44","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.4049\/jimmunol.1102543","article-title":"Activation of the NLRP3 inflammasome by group B streptococci","volume":"188","author":"Costa","year":"2012","journal-title":"J. Immunol."},{"key":"2025030417510564500_r45","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1074\/jbc.C114.548982","article-title":"RNA and \u03b2-hemolysin of group B Streptococcus induce interleukin-1\u03b2 (IL-1\u03b2) by activating NLRP3 inflammasomes in mouse macrophages","volume":"289","author":"Gupta","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2025030417510564500_r46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"2025030417510564500_r47","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/ni986","article-title":"TRAM is specifically involved in the toll-like receptor 4-mediated MyD88-independent signaling pathway","volume":"4","author":"Yamamoto","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025030417510564500_r48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/ni1297","article-title":"The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9","volume":"7","author":"Tabeta","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025030417510564500_r49","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.4049\/jimmunol.180.9.6149","article-title":"Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis","volume":"180","author":"Henneke","year":"2008","journal-title":"J. Immunol."},{"key":"2025030417510564500_r50","first-page":"1062","article-title":"Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis","volume-title":"Immunity","author":"Girbl","year":"2018"},{"key":"2025030417510564500_r51","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/sj.bjp.0704087","article-title":"CXC chemokines, MIP-2 and KC, induce P-selectin-dependent neutrophil rolling and extravascular migration in vivo","volume":"133","author":"Zhang","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"2025030417510564500_r52","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.immuni.2010.07.018","article-title":"Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis","volume":"33","author":"Chou","year":"2010","journal-title":"Immunity"},{"key":"2025030417510564500_r53","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.it.2011.06.008","article-title":"Neutrophils cascading their way to inflammation","volume":"32","author":"Sadik","year":"2011","journal-title":"Trends Immunol."},{"key":"2025030417510564500_r54","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417510564500_r55","doi-asserted-by":"crossref","first-page":"E3177","DOI":"10.1073\/pnas.1213797109","article-title":"Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc\u03b3R signaling","volume":"109","author":"Sadik","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417510564500_r56","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.devcel.2012.02.003","article-title":"LTB4 is a signal-relay molecule during neutrophil chemotaxis","volume":"22","author":"Afonso","year":"2012","journal-title":"Dev. Cell"},{"key":"2025030417510564500_r57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/imr.12458","article-title":"Neutrophil swarming: an essential process of the neutrophil tissue response","volume":"273","author":"Kienle","year":"2016","journal-title":"Immunol. Rev."},{"key":"2025030417510564500_r58","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature12175","article-title":"Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo","volume":"498","author":"L\u00e4mmermann","year":"2013","journal-title":"Nature"},{"key":"2025030417510564500_r59","doi-asserted-by":"crossref","first-page":"18073","DOI":"10.1073\/pnas.1008737107","article-title":"In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation","volume":"107","author":"Kreisel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. 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Microbiol."},{"key":"2025030417510564500_r66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007244","article-title":"Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice","volume":"14","author":"Brandt","year":"2018","journal-title":"PLoS Pathog."},{"key":"2025030417510564500_r67","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","author":"Soehnlein","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417510564500_r68","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/jid.2010.37","article-title":"Staphylococcus aureus stimulates neutrophil targeting chemokine expression in keratinocytes through an autocrine IL-1alpha signaling loop","volume":"130","author":"Olaru","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"2025030417510564500_r69","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1128\/IAI.72.1.295-300.2004","article-title":"Interleukin-18 is an essential element in host resistance to experimental group B streptococcal disease in neonates","volume":"72","author":"Cusumano","year":"2004","journal-title":"Infect. Immun."},{"key":"2025030417510564500_r70","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1128\/iai.65.9.3731-3735.1997","article-title":"Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci","volume":"65","author":"Mancuso","year":"1997","journal-title":"Infect. Immun."},{"key":"2025030417510564500_r71","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.4049\/jimmunol.1200898","article-title":"Cutting edge: TLR13 is a receptor for bacterial RNA","volume":"189","author":"Hidmark","year":"2012","journal-title":"J. Immunol."},{"key":"2025030417510564500_r72","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/embor.2010.189","article-title":"Macrophages recognize streptococci through bacterial single-stranded RNA","volume":"12","author":"Deshmukh","year":"2011","journal-title":"EMBO Rep."},{"key":"2025030417510564500_r73","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.4049\/jimmunol.1403176","article-title":"TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-\u03b2 production via a TAK1-IKK\u03b2-IRF5 signaling pathway","volume":"195","author":"Bergstr\u00f8m","year":"2015","journal-title":"J. Immunol."},{"key":"2025030417510564500_r74","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.4049\/jimmunol.1403173","article-title":"TLR8 senses bacterial RNA in human monocytes and plays a nonredundant role for recognition of Streptococcus pyogenes","volume":"195","author":"Eigenbrod","year":"2015","journal-title":"J. Immunol."},{"key":"2025030417510564500_r75","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3389\/fimmu.2017.01243","article-title":"Toll-like receptor 8 is a major sensor of group B Streptococcus but not Escherichia coli in human primary monocytes and macrophages","volume":"8","author":"Ehrnstr\u00f6m","year":"2017","journal-title":"Front. Immunol."},{"key":"2025030417510564500_r76","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1182\/blood-2008-07-019307","article-title":"TLRs and innate immunity","volume":"113","author":"Beutler","year":"2009","journal-title":"Blood"},{"key":"2025030417510564500_r77","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"2025030417510564500_r78","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3389\/fimmu.2019.01209","article-title":"Human toll-like receptor 8 (TLR8) is an important sensor of pyogenic bacteria, and is attenuated by cell surface TLR signaling","volume":"10","author":"Moen","year":"2019","journal-title":"Front. Immunol."},{"key":"2025030417510564500_r79","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1093620","article-title":"Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8","volume":"303","author":"Heil","year":"2004","journal-title":"Science"},{"key":"2025030417510564500_r80","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.4049\/jimmunol.172.7.3989","article-title":"Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells","volume":"172","author":"Koski","year":"2004","journal-title":"J. Immunol."},{"key":"2025030417510564500_r81","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1126\/science.1220363","article-title":"TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification","volume":"337","author":"Oldenburg","year":"2012","journal-title":"Science"},{"key":"2025030417510564500_r82","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.molimm.2009.11.003","article-title":"A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition","volume":"47","author":"Liu","year":"2010","journal-title":"Mol. 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