{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:26:05Z","timestamp":1783031165079,"version":"3.54.6"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1033198"],"award-info":[{"award-number":["1033198"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1113577"],"award-info":[{"award-number":["1113577"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1042775"],"award-info":[{"award-number":["1042775"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1154325"],"award-info":[{"award-number":["1154325"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Reid Charitable Trusts"},{"DOI":"10.13039\/501100001061","name":"Rebecca L. Cooper Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANZ Trustees"},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["J 3752-B28"],"award-info":[{"award-number":["J 3752-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Development Fund, Macau SAR","award":["0055\/2019\/A1"],"award-info":[{"award-number":["0055\/2019\/A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The importance of tetraspanin proteins in regulating migration has been demonstrated in many diverse cellular systems. However, the function of the leukocyte-restricted tetraspanin CD53 remains obscure. We therefore hypothesized that CD53 plays a role in regulating leukocyte recruitment and tested this hypothesis by examining responses of CD53-deficient mice to a range of inflammatory stimuli. Deletion of CD53 significantly reduced neutrophil recruitment to the acutely inflamed peritoneal cavity. Intravital microscopy revealed that in response to several inflammatory and chemotactic stimuli, absence of CD53 had only minor effects on leukocyte rolling and adhesion in postcapillary venules. In contrast, Cd53\u2212\/\u2212 mice showed a defect in leukocyte transmigration induced by TNF, CXCL1 and CCL2, and a reduced capacity for leukocyte retention on the endothelial surface under shear flow. Comparison of adhesion molecule expression in wild-type and Cd53\u2212\/\u2212 neutrophils revealed no alteration in expression of \u03b22 integrins, whereas L-selectin was almost completely absent from Cd53\u2212\/\u2212 neutrophils. In addition, Cd53\u2212\/\u2212 neutrophils showed defects in activation-induced cytoskeletal remodeling and translocation to the cell periphery, responses necessary for efficient transendothelial migration, as well as increased \u03b13 integrin expression. These alterations were associated with effects on inflammation, so that in Cd53\u2212\/\u2212 mice, the onset of neutrophil-dependent serum-induced arthritis was delayed. Together, these findings demonstrate a role for tetraspanin CD53 in promotion of neutrophil transendothelial migration and inflammation, associated with CD53-mediated regulation of L-selectin expression, attachment to the endothelial surface, integrin expression and trafficking, and cytoskeletal function.<\/jats:p>","DOI":"10.4049\/jimmunol.1901054","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T19:15:11Z","timestamp":1591989311000},"page":"521-532","source":"Crossref","is-referenced-by-count":18,"title":["Leukocyte Tetraspanin CD53 Restrains \u03b13 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-1168","authenticated-orcid":false,"given":"Louisa","family":"Yeung","sequence":"first","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]},{"name":"Department of Immunology, Monash University, Alfred Research Alliance , Melbourne, Victoria 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M L","family":"Anderson","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet L","family":"Wee","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]},{"name":"Department of Immunology, Monash University, Alfred Research Alliance , Melbourne, Victoria 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-5651","authenticated-orcid":false,"given":"Maria C","family":"Demaria","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monash University, Alfred Research Alliance , Melbourne, Victoria 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Finsterbusch","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-5585","authenticated-orcid":false,"given":"Yuxin S","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Hall","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brodie C","family":"Smith","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-0472","authenticated-orcid":false,"given":"Wendy","family":"Dankers","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin D","family":"Elgass","sequence":"additional","affiliation":[{"name":"Monash Micro Imaging, Monash University , Clayton, Victoria 3800 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P","family":"Wicks","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]},{"name":"Department of Medical Biology, The University of Melbourne , Parkville, Victoria 3050 ,","place":["Australia"]},{"name":"Department of Rheumatology, The Royal Melbourne Hospital , Parkville, Victoria 3050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-4517","authenticated-orcid":false,"given":"Hang Fai","family":"Kwok","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Faculty of Health Sciences, University of Macau , Taipa, Macau Special Administrative Region ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2177-5214","authenticated-orcid":false,"given":"Mark D","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monash University, Alfred Research Alliance , Melbourne, Victoria 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2354-357X","authenticated-orcid":false,"given":"Michael J","family":"Hickey","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Clayton, Victoria 3168 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