{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:31:01Z","timestamp":1784287861117,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dendritic cells (DCs) participate in the pathogenesis of several diseases. We investigated DCs and the connection between mucosa and joints in a murine model of Yersinia enterocolitica O:3\u2013induced reactive arthritis (ReA) in TNFRp55\u2212\/\u2212 mice. DCs of mesenteric lymph nodes (MLN) and joint regional lymph nodes (RLN) were analyzed in TNFRp55\u2212\/\u2212 and wild-type mice. On day 14 after Y. enterocolitica infection (arthritis onset), we found that under TNFRp55 deficiency, migratory (MHChighCD11c+) DCs increased significantly in RLN. Within these RLN, resident (MHCintCD11c+) DCs increased on days 14 and 21. Similar changes in both migratory and resident DCs were also detected on day 14 in MLN of TNFRp55\u2212\/\u2212 mice. In vitro, LPS-stimulated migratory TNFRp55\u2212\/\u2212 DCs of MLN increased IL-12\/23p40 compared with wild-type mice. In addition, TNFRp55\u2212\/\u2212 bone marrow\u2013derived DCs in a TNFRp55\u2212\/\u2212 MLN microenvironment exhibited higher expression of CCR7 after Y. enterocolitica infection. The major intestinal DC subsets (CD103+CD11b\u2212, CD103\u2212CD11b+, and CD103+CD11b+) were found in the RLN of Y. enterocolitica\u2013infected TNFRp55\u2212\/\u2212 mice. Fingolimod (FTY720) treatment of Y. enterocolitica\u2013infected mice reduced the CD11b\u2212 subset of migratory DCs in RLN of TNFRp55\u2212\/\u2212 mice and significantly suppressed the severity of ReA in these mice. This result was associated with decreased articular IL-12\/23p40 and IFN-\u03b3 levels. In vitro FTY720 treatment downregulated CCR7 on Y. enterocolitica\u2013infected bone marrow\u2013derived DCs and purified MLN DCs, which may explain the mechanism underlying the impairment of DCs in RLN induced by FTY720. Taken together, data indicate the migration of intestinal DCs to RLN and the contribution of these cells in the immunopathogenesis of ReA, which may provide evidence for controlling this disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1901137","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T20:35:14Z","timestamp":1583181314000},"page":"1859-1868","source":"Crossref","is-referenced-by-count":11,"title":["Dendritic Cells of Mesenteric and Regional Lymph Nodes Contribute to <i>Yersinia enterocolitica<\/i> O:3\u2013Induced Reactive Arthritis in <i>TNFRp55\u2212\/\u2212<\/i> Mice"],"prefix":"10.1093","volume":"204","author":[{"given":"Juan E","family":"Silva","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]},{"name":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas-San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas-Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-9644","authenticated-orcid":false,"given":"Andrea C","family":"Mayordomo","sequence":"additional","affiliation":[{"name":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas-San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas-Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel N","family":"Dave","sequence":"additional","affiliation":[{"name":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas-San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas-Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Aguilera Merlo","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo J","family":"Eli\u00e7abe","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]},{"name":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas-San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas-Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-5786","authenticated-orcid":false,"given":"Mar\u00eda S","family":"Di Genaro","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]},{"name":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas-San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas-Universidad Nacional de San Luis , 5700 San Luis ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"2025030417511251300_r1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.autrev.2018.04.002","article-title":"Nature versus nurture in the spectrum of rheumatic diseases: classification of spondyloarthritis as autoimmune or autoinflammatory","volume":"17","author":"Generali","year":"2018","journal-title":"Autoimmun. 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