{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:44Z","timestamp":1787585984749,"version":"build-2736575974"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Individuals with Down syndrome (DS) develop Alzheimer's disease (AD)\u2013related neuropathology, characterized by amyloid plaques with amyloid \u03b2 (A\u03b2) and neurofibrillary tangles with tau accumulation. Peripheral inflammation and the innate immune response are elevated in DS. Triggering receptor expressed in myeloid cells 2 (TREM2) genetic variants are risk factors for AD and other neurodegenerative diseases. Soluble TREM2 (sTREM2), a soluble cleavage product of TREM2, is elevated in AD cerebrospinal fluid and positively correlates with cognitive decline. There is relatively little information about TREM2 in DS. Our objective was to examine the relationship between sTREM2 and inflammatory markers in young adults with DS, prior to the development of dementia symptoms. Because TREM2 plays a role in the innate immune response and has been associated with dementia, the hypothesis of this exploratory study was that young adults with DS predementia (n = 15, mean age = 29.5 y) would exhibit a different relationship between sTREM2 and inflammatory markers in plasma, compared with neurotypical, age-matched controls (n = 16, mean age = 29.6 y). Indeed, young adults with DS had significantly elevated plasma sTREM2 and inflammatory markers. Additionally, in young adults with DS, sTREM2 correlated positively with 24 of the measured cytokines, whereas there were no significant correlations in the control group. Hierarchical clustering of sTREM2 and cytokine concentrations also differed between the groups, supporting the hypothesis that its function is altered in people with DS predementia. This preliminary report of human plasma provides a basis for future studies investigating the relationship between TREM2 and the broader immune response predementia.<\/jats:p>","DOI":"10.4049\/jimmunol.1901166","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T16:35:15Z","timestamp":1579538115000},"page":"1111-1118","source":"Crossref","is-referenced-by-count":26,"title":["An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-7911","authenticated-orcid":false,"given":"Grace E","family":"Weber","sequence":"first","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-7130","authenticated-orcid":false,"given":"Katherine A","family":"Koenig","sequence":"additional","affiliation":[{"name":"Imaging Institute, Cleveland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1621-4711","authenticated-orcid":false,"given":"Maria","family":"Khrestian","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Shao","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4125-1351","authenticated-orcid":false,"given":"Elizabeth D","family":"Tuason","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gramm","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic , Cleveland, OH 44195"},{"name":"Cologne Center for Genomics, University of Cologne , 50931 Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Lal","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Leverenz","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lou Ruvo Center for Brain Health, Neurological Institute, Clevland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M","family":"Bekris","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic , Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,1]]},"reference":[{"key":"2025030417510844700_r1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1469-8749.2004.tb00483.x","article-title":"Clinical, social, and ethical implications of changing life expectancy in Down syndrome","volume":"46","author":"Bittles","year":"2004","journal-title":"Dev. Med. Child Neurol."},{"key":"2025030417510844700_r2","first-page":"51","article-title":"Characteristics of adults with down syndrome: prevalence of age-related conditions","volume":"1","author":"Carf\u00ec","year":"2014","journal-title":"Front. Med. (Lausanne)"},{"key":"2025030417510844700_r3","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1001\/jamaneurol.2018.2210","article-title":"Prevalence of aging, dementia, and multimorbidity in older adults with down syndrome","volume":"75","author":"Bayen","year":"2018","journal-title":"JAMA Neurol."},{"key":"2025030417510844700_r4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.mayocp.2013.04.024","article-title":"The National Task Group on Intellectual Disabilities and Dementia Practices consensus recommendations for the evaluation and management of dementia in adults with intellectual disabilities","volume":"88","author":"Moran","year":"2013","journal-title":"Mayo Clin. 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Alzheimers Dis."},{"key":"2025030417510844700_r15","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.jalz.2016.05.001","article-title":"An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: relation to cognitive decline and longitudinal evaluation","volume":"12","author":"Iulita","year":"2016","journal-title":"Alzheimers Dement."},{"key":"2025030417510844700_r16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-4933-8-4","article-title":"Inflammatory and Immunological parameters in adults with Down syndrome","volume":"8","author":"Trotta","year":"2011","journal-title":"Immun. Ageing"},{"key":"2025030417510844700_r17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archneurol.2009.328","article-title":"The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration","volume":"67","author":"Yu","year":"2010","journal-title":"Arch. Neurol."},{"key":"2025030417510844700_r18","doi-asserted-by":"crossref","first-page":"84489","DOI":"10.18632\/oncotarget.21060","article-title":"Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"2025030417510844700_r19","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4049\/jimmunol.171.2.594","article-title":"Pattern recognition by TREM-2: binding of anionic ligands","volume":"171","author":"Daws","year":"2003","journal-title":"J. Immunol."},{"key":"2025030417510844700_r20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2","volume":"201","author":"Takahashi","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025030417510844700_r21","first-page":"1569","article-title":"TREM2 and neurodegenerative disease","volume":"369","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"2025030417510844700_r22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"2025030417510844700_r23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/jnnp.74.6.825-a","article-title":"An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene. [Published erratum appears in 2003 J. Neurol. Neurosurg. Psychiatry 74: 1165.]","volume":"74","author":"Soragna","year":"2003","journal-title":"J. Neurol. Neurosurg. 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Neurodegener."},{"key":"2025030417510844700_r27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jneuroim.2018.03.003","article-title":"Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease","volume":"319","author":"Bekris","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"2025030417510844700_r28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neulet.2018.08.038","article-title":"Soluble TREM2 changes during the clinical course of Alzheimer\u2019s disease: a meta-analysis","volume":"686","author":"Liu","year":"2018","journal-title":"Neurosci. 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Med."},{"key":"2025030417510844700_r31","doi-asserted-by":"crossref","first-page":"466","DOI":"10.15252\/emmm.201506123","article-title":"sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer\u2019s disease and associate with neuronal injury markers","volume":"8","author":"Su\u00e1rez-Calvet","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"2025030417510844700_r32","first-page":"eaav6221","article-title":"Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer\u2019s disease","volume-title":"Sci. Transl. Med.","author":"Ewers","year":"2019"},{"key":"2025030417510844700_r33","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3233\/JAD-170814","article-title":"Erythromyeloid-derived TREM2: a major determinant of Alzheimer\u2019s disease pathology in down syndrome","volume":"61","author":"Raha-Chowdhury","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"2025030417510844700_r34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/JAD-181179","article-title":"Choroid plexus acts as gatekeeper for TREM2, abnormal accumulation of ApoE, and fibrillary tau in Alzheimer\u2019s disease and in down syndrome dementia","volume":"69","author":"Raha-Chowdhury","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"2025030417510844700_r35","first-page":"1","article-title":"The mental status examination in patients with mental retardation and developmental disabilities","volume":"4","author":"Levitas","year":"2001","journal-title":"Ment. Health Aspects Dev. Disabil."},{"key":"2025030417510844700_r36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1192\/bjp.bp.106.024984","article-title":"Dementia screening questionnaire for individuals with intellectual disabilities","volume":"190","author":"Deb","year":"2007","journal-title":"Br. J. Psychiatry"},{"key":"2025030417510844700_r37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1365-2788.1996.tb00642.x","article-title":"Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR)","volume":"40","author":"Evenhuis","year":"1996","journal-title":"J. Intellect. Disabil. Res."},{"key":"2025030417510844700_r38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/JAD-2008-13303","article-title":"Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels","volume":"13","author":"Bekris","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"2025030417510844700_r39","author":"Wei","year":"2017"},{"key":"2025030417510844700_r40","author":"Warnes","year":"2019"},{"key":"2025030417510844700_r41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107218","article-title":"Altered expression of immune-related genes in children with Down syndrome","volume":"9","author":"Zampieri","year":"2014","journal-title":"PLoS One"},{"key":"2025030417510844700_r42","first-page":"701","article-title":"Interleukins, from 1 to 37, and interferon-\u03b3: receptors, functions, and roles in diseases. [Published erratum appears in 2011 J. Allergy Clin. Immunol. 128: 739.]","volume-title":"J. Allergy Clin. Immunol.","author":"Akdis","year":"2011"},{"key":"2025030417510844700_r43","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1158\/1078-0432.CCR-06-2416","article-title":"Vascular endothelial growth factor and its relationship to inflammatory mediators","volume":"13","author":"Angelo","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"2025030417510844700_r44","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s10753-016-0477-1","article-title":"Aptamers against pro- and anti-inflammatory cytokines: a review","volume":"40","author":"Boshtam","year":"2017","journal-title":"Inflammation"},{"key":"2025030417510844700_r45","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cmet.2014.05.009","article-title":"IL-6 strikes a balance in metabolic inflammation","volume":"19","author":"Covarrubias","year":"2014","journal-title":"Cell Metab."},{"key":"2025030417510844700_r46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"2025030417510844700_r47","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/iub.361","article-title":"The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis","volume":"62","author":"Martins","year":"2010","journal-title":"IUBMB Life"},{"key":"2025030417510844700_r48","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","article-title":"Anti-inflammatory cytokines","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"key":"2025030417510844700_r49","doi-asserted-by":"crossref","first-page":"29355","DOI":"10.1074\/jbc.R200003200","article-title":"Cytokine and cytokine receptor pleiotropy and redundancy","volume":"277","author":"Ozaki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025030417510844700_r50","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cytogfr.2004.01.004","article-title":"The role of epidermal growth factor and its receptors in mammalian CNS","volume":"15","author":"Wong","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025030417510844700_r51","article-title":"Fibroblast growth factors: biology, function, and application for tissue regeneration","volume":"2010","author":"Yun","year":"2010","journal-title":"J. Tissue Eng."},{"key":"2025030417510844700_r52","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/bjh.13096","article-title":"Haematopoietic development and leukaemia in Down syndrome","volume":"167","author":"Roberts","year":"2014","journal-title":"Br. J. Haematol."},{"key":"2025030417510844700_r53","article-title":"Altered peripheral profile of blood cells in Alzheimer disease: a hospital-based case-control study","volume":"96","author":"Chen","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"2025030417510844700_r54","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/syn.21651","article-title":"Peripheral markers of Alzheimer\u2019s disease: surveillance of white blood cells","volume":"67","author":"Shad","year":"2013","journal-title":"Synapse"},{"key":"2025030417510844700_r55","first-page":"e9712","article-title":"CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline","volume-title":"EMBO Mol. 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Psychosom."},{"key":"2025030417510844700_r58","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1182\/blood.V91.4.1101","article-title":"c-kit ligand and Flt3 ligand: stem\/progenitor cell factors with overlapping yet distinct activities","volume":"91","author":"Lyman","year":"1998","journal-title":"Blood"},{"key":"2025030417510844700_r59","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/08977190410001700989","article-title":"FLT3: receptor and ligand","volume":"22","author":"Drexler","year":"2004","journal-title":"Growth Factors"},{"key":"2025030417510844700_r60","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1073\/pnas.87.19.7732","article-title":"Identification of three related human GRO genes encoding cytokine functions","volume":"87","author":"Haskill","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417510844700_r61","first-page":"5596","article-title":"Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. [Published erratum appears in 1990 Mol. Cell Biol. 10: 6821.]","volume":"10","author":"Iida","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"2025030417510844700_r62","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ni.1744","article-title":"Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin","volume":"10","author":"Otero","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030417510844700_r63","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev.iy.07.040189.003205","article-title":"The biology of cachectin\/TNF--a primary mediator of the host response","volume":"7","author":"Beutler","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417510844700_r64","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-2094-2-23","article-title":"Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer\u2019s disease mice","volume":"2","author":"Janelsins","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"2025030417510844700_r65","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0197-4580(01)00291-3","article-title":"The role of TNF and its receptors in Alzheimer\u2019s disease","volume":"22","author":"Perry","year":"2001","journal-title":"Neurobiol. 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