{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:36:56Z","timestamp":1788183416494,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cancer prognosis often correlates with the number of tumor-infiltrating CD8 T cells, but many of these cells recognize pathogens that commonly infect humans. The contribution of pathogen-specific \u201cbystander\u201d CD8 T cells to antitumor immunity remains largely unknown. Inflammatory cytokines are sufficient for memory CD8 T cell activation and gain of effector functions, indicating tumor-derived inflammation could facilitate pathogen-specific CD8 T cells to participate in tumor control. In this study, we show in contrast to tumor-specific CD8 T cells that pathogen-specific primary memory CD8 T cells inside tumor were not able to exert their effector functions and influence tumor progression. However, infection-induced memory CD8 T cells with defined history of repeated Ag encounters (i.e., quaternary memory) showed increased sensitivity to tumor-derived inflammation that resulted in activation, gain of effector functions, and better control of tumor growth. Thus, memory CD8 T cells with heightened ability to recognize environmental inflammatory stimuli can contribute to antitumor immunity in the absence of cognate Ag recognition.<\/jats:p>","DOI":"10.4049\/jimmunol.1901172","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T20:34:25Z","timestamp":1581539665000},"page":"1431-1435","source":"Crossref","is-referenced-by-count":32,"title":["Cutting Edge: Antitumor Immunity by Pathogen-Specific CD8 T Cells in the Absence of Cognate Antigen Recognition"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-8797","authenticated-orcid":false,"given":"Derek B","family":"Danahy","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-8541","authenticated-orcid":false,"given":"Roger R","family":"Berton","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-2439","authenticated-orcid":false,"given":"Vladimir P","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Microbiology and Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,15]]},"reference":[{"key":"2025030417511042900_r1","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1158\/0008-5472.CAN-03-3066","article-title":"Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance","volume":"64","author":"Zippelius","year":"2004","journal-title":"Cancer Res."},{"key":"2025030417511042900_r2","doi-asserted-by":"crossref","first-page":"16168","DOI":"10.1073\/pnas.242600099","article-title":"Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells","volume":"99","author":"Yee","year":"2002","journal-title":"Proc. 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