{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:43:31Z","timestamp":1741153411975,"version":"3.38.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lymphotoxin \u03b2 receptor (LT\u03b2R) signaling is crucial for lymphoid tissue organogenesis and immune homeostasis. To identify novel regulatory mechanisms for signaling, we implemented a two-step screen that uses coexpression analysis of human fibroblasts undergoing LT\u03b2R stimulation and affinity-purification mass spectrometry for the LT\u03b2R signaling protein TNFR-associated factor 3 (TRAF3). We identify Ewing sarcoma (EWS) protein as a novel LT\u03b2R signaling component that associates with TRAF3 but not with TNFR-associated factor 2 (TRAF2). The EWS:TRAF3 complex forms under unligated conditions that are disrupted following activation of the LT\u03b2R. We conclude that EWS limits expression of proinflammatory molecules, GM-CSF, and ERK-2, promoting immune homeostasis.<\/jats:p>","DOI":"10.4049\/jimmunol.1901260","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T21:39:16Z","timestamp":1579729156000},"page":"1085-1090","source":"Crossref","is-referenced-by-count":2,"title":["Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin \u03b2 Receptor Signaling"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0011-3844","authenticated-orcid":false,"given":"Richard","family":"Virgen-Slane","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-7034","authenticated-orcid":false,"given":"Ricardo G","family":"Correa","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parham","family":"Ramezani-Rad","sequence":"additional","affiliation":[{"name":"National Cancer Institute\u2013Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-5548","authenticated-orcid":false,"given":"Seth","family":"Steen-Fuentes","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Detanico","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"DiCandido","sequence":"additional","affiliation":[{"name":"Department of Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc. , Ridgefield, CT 06877"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharmaceuticals, Inc. , Ridgefield, CT 06877"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-418X","authenticated-orcid":false,"given":"Carl F","family":"Ware","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,1]]},"reference":[{"key":"2025030417510828600_r1","article-title":"Tumor necrosis factor superfamily in innate immunity and inflammation","volume":"7","author":"\u0160ed\u00fd","year":"2014","journal-title":"Cold Spring Harb. 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